PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29399118-0	2018	Epidermal growth factor receptor aptamer-conjugated polymer-lipid hybrid nanoparticles enhance salinomycin delivery to osteosarcoma and cancer stem cells.	salinomycin	95-106	epidermal growth factor receptor	Homo sapiens	0-32	
29399118-6	2018	The present study aimed to develop EGFR aptamer-conjugated salinomycin-loaded polymer-lipid hybrid nanoparticles (EGFR-SNPs) to target both osteosarcoma cells and CSCs.	salinomycin	59-70	epidermal growth factor receptor	Homo sapiens	35-39	
29399118-6	2018	The present study aimed to develop EGFR aptamer-conjugated salinomycin-loaded polymer-lipid hybrid nanoparticles (EGFR-SNPs) to target both osteosarcoma cells and CSCs.	salinomycin	59-70	epidermal growth factor receptor	Homo sapiens	114-118	
29399118-7	2018	The results revealed that EGFR was overexpressed in these cells, and that EGFR-SNPs possessed a small size of 95 nm, suitable drug encapsulation efficiency (63%) and sustained drug release over 120 h. EGFR-SNPs targeted EGFR-overexpressing osteosarcoma cells and CSCs, resulting in an enhanced cytotoxic effect compared with non-targeted SNPs and salinomycin.	salinomycin	347-358	epidermal growth factor receptor	Homo sapiens	74-78	
29399118-7	2018	The results revealed that EGFR was overexpressed in these cells, and that EGFR-SNPs possessed a small size of 95 nm, suitable drug encapsulation efficiency (63%) and sustained drug release over 120 h. EGFR-SNPs targeted EGFR-overexpressing osteosarcoma cells and CSCs, resulting in an enhanced cytotoxic effect compared with non-targeted SNPs and salinomycin.	salinomycin	347-358	epidermal growth factor receptor	Homo sapiens	74-78	
29399118-7	2018	The results revealed that EGFR was overexpressed in these cells, and that EGFR-SNPs possessed a small size of 95 nm, suitable drug encapsulation efficiency (63%) and sustained drug release over 120 h. EGFR-SNPs targeted EGFR-overexpressing osteosarcoma cells and CSCs, resulting in an enhanced cytotoxic effect compared with non-targeted SNPs and salinomycin.	salinomycin	347-358	epidermal growth factor receptor	Homo sapiens	74-78	
29399118-8	2018	Notably, EGFR-SNPs was able to reduce the osteosarcoma tumorsphere formation rate and proportion of CD133+ osteosarcoma CSCs in the osteosarcoma cell lines more effectively compared with SNPs and salinomycin, suggesting that EGFR-SNPs effectively reduced the proportion of osteosarcoma CSCs.	salinomycin	196-207	epidermal growth factor receptor	Homo sapiens	9-13	
29399118-9	2018	In conclusion, the interaction of EGFR aptamers and EGFR is a potential approach to promote the effective delivery of salinomycin to osteosarcoma.	salinomycin	118-129	epidermal growth factor receptor	Homo sapiens	34-38	
29399118-9	2018	In conclusion, the interaction of EGFR aptamers and EGFR is a potential approach to promote the effective delivery of salinomycin to osteosarcoma.	salinomycin	118-129	epidermal growth factor receptor	Homo sapiens	52-56