PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27045981-0	2016	CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel.	salinomycin	124-135	CD44 molecule (Indian blood group)	Homo sapiens	0-4	
30273566-7	2018	salinomycin treatment also suppressed the sphere formation ability of RCC cells and decreased the expressions of CD105, ALDH1 and CD44, biomarkers for reflecting the stemness of RCC cells.	salinomycin	0-11	CD44 molecule (Indian blood group)	Homo sapiens	130-134	
27462592-10	2016	And growth inhibition of OVCAR3 CD44(+)CD117(+) cells by paclitaxel combined with salinomycin was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay.	salinomycin	82-93	CD44 molecule (Indian blood group)	Homo sapiens	32-36	
27462592-12	2016	Treatment with a combination of paclitaxel and salinomycin demonstrated growth inhibition of OVCAR3 CD44(+)CD117(+) cells.	salinomycin	47-58	CD44 molecule (Indian blood group)	Homo sapiens	100-104	
26528725-0	2015	Salinomycin Promotes Anoikis and Decreases the CD44+/CD24- Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells.	salinomycin	0-11	CD44 molecule (Indian blood group)	Homo sapiens	47-51	
26528725-6	2015	Notably, salinomycin inhibited the formation of mammospheres and effectively reduced the CD44+/CD24- stem-like population during anchorage-independent growth.	salinomycin	9-20	CD44 molecule (Indian blood group)	Homo sapiens	89-93	
26352531-3	2015	In the present study, we examined the ability of salinomycin to induce cell death in the colorectal cancer stem cell line CD44+EpCAM+ HCT-116, and we measured its in vivo tumor inhibition capacity.	salinomycin	49-60	CD44 molecule (Indian blood group)	Homo sapiens	122-126	
26352531-4	2015	Salinomycin dose-dependently induced cytotoxicity in the CD44+EpCAM+ HCT-116 cells and inhibited colony formation.	salinomycin	0-11	CD44 molecule (Indian blood group)	Homo sapiens	57-61	
22215106-6	2012	Salinomycin impacted on prostate cancer stem cell functions as evidenced by reduced aldehyde dehydrogenase activity and the fraction of CD44(+) cells.	salinomycin	0-11	CD44 molecule (Indian blood group)	Homo sapiens	136-140	
26407842-6	2015	TUNEL analysis of MDA-MB-231-derived xenografts revealed that salinomycin administration elicited a significant reduction in tumor growth with a marked downregulation of ALDH1 and CD44 levels, but seemingly without the induction of apoptosis.	salinomycin	62-73	CD44 molecule (Indian blood group)	Homo sapiens	180-184	
25483103-7	2015	Targeting CD44 with salinomycin and siRNA could inhibit cell transition and decrease PCa invasion.	salinomycin	20-31	CD44 molecule (Indian blood group)	Homo sapiens	10-14	
24841425-1	2014	Salinomycin, a naturally occurring polyether ionophore was recently found to selectively reduce the proportion of CD44(+)/CD24(-) cells, a phenotype associated with breast cancer stem cells.	salinomycin	0-11	CD44 molecule (Indian blood group)	Homo sapiens	114-118	
24841425-7	2014	Importantly, the proportion of CD44(+)/CD24(-) cells showed a pronounced U-shaped dose response curve for salinomycin and its derivatives, but not for paclitaxel.	salinomycin	106-117	CD44 molecule (Indian blood group)	Homo sapiens	31-35	
24841425-8	2014	The concentration for maximum response in this assay followed differences in IC50 for salinomycin and its analogues, which emphasizes the importance of taking concentration dependence into account when comparing effects on the CD44(+)/CD24(-) phenotype.	salinomycin	86-97	CD44 molecule (Indian blood group)	Homo sapiens	227-231	
23176396-10	2012	It was observed that salinomycin significantly inhibited sphere forming-capability and repressed the expression of CD44 and BMI-1 by 3.2-fold and 6.2-fold, respectively.	salinomycin	21-32	CD44 molecule (Indian blood group)	Homo sapiens	115-119	
34130123-9	2021	Compound 17 was more potent than SAL in inhibiting cell migration and cell renewal properties of MDA-MB-231 cells, as well as inducing selective loss of the CD44+/CD24/low stem-cell-like subpopulation in both monolayer (2D) and organoid (3D) culture.	salinomycin	33-36	CD44 molecule (Indian blood group)	Homo sapiens	157-161	
21558812-6	2011	This stability allowed testing of segregated subpopulations for relative sensitivity to the cytotoxic agent cisplatin in comparison to salinomycin, a compound with reported activity against CD44(+)CD24(-) stem-like cells in breast carcinomas.	salinomycin	135-146	CD44 molecule (Indian blood group)	Homo sapiens	190-194	
34308783-7	2021	It was observed that mRNA expression patterns of CD44v6, Nanog, AKT1, CDKN2A and beta-catenin of Salinomycin treated CD44+ cells.	salinomycin	97-108	CD44 molecule (Indian blood group)	Homo sapiens	117-121	
34308783-3	2021	Docking of potential investigational molecules and simulation results identified Salinomycin as a potential lead compound that could effectively inhibit CD44 receptor.	salinomycin	81-92	CD44 molecule (Indian blood group)	Homo sapiens	153-157	
34308783-5	2021	Salinomycin demonstrated significant cytotoxic effect towards the CD44+ subpopulation in a dose and time dependent manner.	salinomycin	0-11	CD44 molecule (Indian blood group)	Homo sapiens	66-70	
34308783-9	2021	Thus, this study demonstrated the potential of Salinomycin to target the chemo-resistant circulating CD44 population by attenuating its proliferation and survival.Communicated by Ramaswamy H. Sarma.	salinomycin	47-58	CD44 molecule (Indian blood group)	Homo sapiens	101-105	
33520933-6	2020	By conjugation of CD44 cell-surface glycoprotein with poly(lactic-co-glycolic acid) (PLGA) nanoparticles that are loaded with curcumin and salinomycin, we investigated the cellular uptake of BCSCs, drug release, and therapeutic efficacy against BCSCs.	salinomycin	139-150	CD44 molecule (Indian blood group)	Homo sapiens	18-22	
31177119-10	2019	Since MDA-MB 231 has over 90% cells with the profile CD44+/CD24low/-, these might represent a possible point of attack for salinomycin.	salinomycin	123-134	CD44 molecule (Indian blood group)	Homo sapiens	53-57