PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23395573-11	2013	Compared with control groups, Bax and E-cadherin were significantly upregulated, and Bcl-2 and PCNA were significantly downregulated in Sal-treated cells.	salinomycin	136-139	BCL2 associated X, apoptosis regulator	Homo sapiens	30-33	
23284640-9	2012	Sal induced apoptosis as characterized by an increase in the Bax/Bcl-2 ratio.	salinomycin	0-3	BCL2 associated X, apoptosis regulator	Homo sapiens	61-64	
23176396-9	2012	RESULTS: In putative HNSCC stem cells, salinomycin was found to significantly inhibit cell viability, induce a 71.5% increase in levels of apoptosis, elevate the Bax/Bcl-2 ratio, and work synergistically with cisplatin and paclitaxel in inducing cell death.	salinomycin	39-50	BCL2 associated X, apoptosis regulator	Homo sapiens	162-165	
29989650-6	2018	Treatment with SAL increased Bax/Bcl-2 and cytochrome c expression and activated caspase-3 and -9, thus leading to poly(ADP-ribose) polymerase (PARP) cleavage and resulting in cell apoptosis.	salinomycin	15-18	BCL2 associated X, apoptosis regulator	Homo sapiens	29-32	
21871443-5	2011	Salinomycin triggered apoptosis of PC-3 cells by elevating the intracellular ROS level, which was accompanied by decreased mitochondrial membrane potential, translocation of Bax protein to mitochondria, cytochrome c release to the cytoplasm, activation of the caspase-3 and cleavage of PARP-1, a caspase-3 substrate.	salinomycin	0-11	BCL2 associated X, apoptosis regulator	Homo sapiens	174-177	
26209294-11	2016	The results showed that salinomycin induced apoptosis and G2/M arrest, increased Bax and cleaved Caspase3, decreased Bcl-2 expression, and increased the formation of gamma-H2AX nuclear foci.	salinomycin	24-35	BCL2 associated X, apoptosis regulator	Homo sapiens	81-84	
26492365-8	2015	Compatible with its direct modulation of mitochondrial function, salinomycin was able to induce cell death also in Bax/Bak-less double-knockout MEF cells.	salinomycin	65-76	BCL2 associated X, apoptosis regulator	Homo sapiens	115-118