PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33840199-1	2021	COMT (Catechol-O-methyl transferase), an enzyme that metabolizes catechol, requires magnesium (Mg2+) to maintain its activity.	catechol	65-73	catechol-O-methyltransferase	Mus musculus	0-4	
33840199-1	2021	COMT (Catechol-O-methyl transferase), an enzyme that metabolizes catechol, requires magnesium (Mg2+) to maintain its activity.	catechol	65-73	catechol-O-methyltransferase	Mus musculus	6-35	
30304773-9	2018	We also discuss on the relationship between catechol-O-methyltransferase (COMT), an enzyme that metabolizes catechol, and AMPK during pregnancy.	catechol	44-52	catechol-O-methyltransferase	Mus musculus	74-78	
19426692-5	2009	Here we perform a proteomic based analysis of the livers of COMT-KO mice in search for potential compensatory mechanisms developed to cope with the effects of disrupted catechol metabolism.	catechol	169-177	catechol-O-methyltransferase	Mus musculus	60-64	
23558779-5	2013	The catechol metabolites of ZEN were also shown to inhibit the O-methylation of 2-hydroxy-E2 by hepatic COMT from mouse, rat, steer and piglet, although to a lesser extent than observed with human COMT.	catechol	4-12	catechol-O-methyltransferase	Mus musculus	104-108	
21095460-1	2010	Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of catechol structured compounds such as catecholamines, catecholestrogens, and L-dopa.	catechol	80-88	catechol-O-methyltransferase	Mus musculus	0-28	
21095460-1	2010	Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of catechol structured compounds such as catecholamines, catecholestrogens, and L-dopa.	catechol	80-88	catechol-O-methyltransferase	Mus musculus	30-34	
19930170-1	2009	BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT).	catechol	93-101	catechol-O-methyltransferase	Mus musculus	24-52	
19930170-1	2009	BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT).	catechol	93-101	catechol-O-methyltransferase	Mus musculus	54-58	
19930170-1	2009	BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT).	catechol	93-101	catechol-O-methyltransferase	Mus musculus	143-147	
19930170-1	2009	BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT).	catechol	93-101	catechol-O-methyltransferase	Mus musculus	143-147	
2910532-7	1989	The significantly lower COMT activity in the hamster liver and red blood cells suggests that under chronic estrogen treatment at high doses, the concentration of catechol estrogens in these tissues may exceed the capacity of COMT to effectively catalyse their O-methylation into inactive metabolites.	catechol	162-170	catechol-O-methyltransferase	Mus musculus	24-28	
12884403-1	2003	Catechol-O-methyltransferase (COMT) enzyme is a widely distributed enzyme that catalyses O-methylation of catecholamines and other compounds having a catechol structure.	catechol	106-114	catechol-O-methyltransferase	Mus musculus	0-28	
12884403-1	2003	Catechol-O-methyltransferase (COMT) enzyme is a widely distributed enzyme that catalyses O-methylation of catecholamines and other compounds having a catechol structure.	catechol	106-114	catechol-O-methyltransferase	Mus musculus	30-34	
10637136-3	2000	We hypothesize that PT-CAT inhibits the enzyme catechol-O-methyltransferase (COMT) and therefore potentiates genotoxicity by either PT-CAT itself or the endogenous catechol estrogens (CEs) in susceptible tissues.	catechol	47-55	catechol-O-methyltransferase	Mus musculus	77-81	
10637136-8	2000	In vitro experiments demonstrated that PT treatment resulted in an increase in free CEs, which are normally cleared by COMT and a concurrent decrease in the capacity of hepatic catechol clearance by COMT.	catechol	177-185	catechol-O-methyltransferase	Mus musculus	199-203	
11849292-1	2002	Catechol-O-methyltransferase (COMT) catalyses the O-methylation of compounds having a catechol structure and its main function involves the elimination of biologically active or toxic catechols and their metabolites.	catechol	86-94	catechol-O-methyltransferase	Mus musculus	0-28	
11849292-1	2002	Catechol-O-methyltransferase (COMT) catalyses the O-methylation of compounds having a catechol structure and its main function involves the elimination of biologically active or toxic catechols and their metabolites.	catechol	86-94	catechol-O-methyltransferase	Mus musculus	30-34