PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12810639-1	2003	Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage.	catechol	109-117	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19	
12810639-1	2003	Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage.	catechol	109-117	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27	
12810639-4	2003	Using purified recombinant enzymes, we demonstrated that CYP1A1 and CYP1B1 O-demethylated the methoxyestrogens to catechol estrogens according to Michaelis-Menten kinetics.	catechol	114-122	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	57-63	
29654831-8	2018	This was mirrored by significant downregulating of the expression of estrogen and catechol estrogen-synthesizing enzymes (CYP19, CYP1A1 and CYP1B1) within prostate cancer cells.	catechol	82-90	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	129-135	
10764452-12	2000	Strikingly elevated CYP1A1 transcripts in endometriosis may give rise to significantly increased P-4501A1 enzyme activity and thus promote the development and growth of endometriosis by either activating procarcinogens or inducing the formation of catechol estrogens or both.	catechol	248-256	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	20-26	
16807674-1	2007	Cytochrome P-450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogens and mammary carcinogens into 2-hydroxy catechol metabolites.	catechol	117-125	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-20	
17570247-11	2007	These experiments demonstrated that CYP1A1, CYP1B1, and CYP3A4 are able to oxidize catechol estrogens to their respective quinones, which can further react with GSH, protein, and DNA, the last resulting in depurinating adducts that can lead to mutagenesis.	catechol	83-91	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	36-42	
21402622-1	2011	The cytochrome P450 1A1 (CYP1A1) is a phase I enzyme involved in many oxidative reactions that has attracted considerable attention as a candidate gene for lung cancer susceptibility based on its function as a key factor required for bioactivation of carcinogenic polycyclic aromatic hydrocarbons and catechol oestrogen formation.	catechol	301-309	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	4-23	
21402622-1	2011	The cytochrome P450 1A1 (CYP1A1) is a phase I enzyme involved in many oxidative reactions that has attracted considerable attention as a candidate gene for lung cancer susceptibility based on its function as a key factor required for bioactivation of carcinogenic polycyclic aromatic hydrocarbons and catechol oestrogen formation.	catechol	301-309	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	25-31	
16807674-1	2007	Cytochrome P-450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogens and mammary carcinogens into 2-hydroxy catechol metabolites.	catechol	117-125	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	22-28	
15142886-2	2004	In our present study, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), when treated with the cultured human mammary epithelial (MCF-10A) cells, induced the expression of cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) that are responsible for the oxidation of 17beta-estradiol to produce catechol estrogens.	catechol	281-289	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	165-184	
15142886-6	2004	Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling.	catechol	51-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	22-28	
15142886-6	2004	Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling.	catechol	285-293	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	22-28