PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34423269-5 2021 Further screening of a targeted library of natural compounds in complementary medicine that were enriched with catechol-containing compounds identified rosmarinic acid (RA) as a potent inhibitor of amylin aggregation (estimated inhibitory concentration IC50 = 200-300 nM). catechol 111-119 islet amyloid polypeptide Homo sapiens 198-204 27431615-0 2016 Amylin Amyloid Inhibition by Flavonoid Baicalein: Key Roles of Its Vicinal Dihydroxyl Groups of the Catechol Moiety. catechol 100-108 islet amyloid polypeptide Homo sapiens 0-6 34832900-7 2021 The results showed that catechol-containing compounds 1-6 exhibited Abeta/hIAPP anti-aggregation and disaggregation activities, while compound 7, without catechol, showed no activity. catechol 24-32 islet amyloid polypeptide Homo sapiens 74-79 33389592-7 2021 Our results showed that the compounds with one or two catechol moieties showed strong hIAPP aggregation inhibitory activity and Abeta42/hIAPP disaggregation activity; and the non-catechol type compounds showed little or no activity. catechol 54-62 islet amyloid polypeptide Homo sapiens 86-91 33389592-7 2021 Our results showed that the compounds with one or two catechol moieties showed strong hIAPP aggregation inhibitory activity and Abeta42/hIAPP disaggregation activity; and the non-catechol type compounds showed little or no activity. catechol 54-62 islet amyloid polypeptide Homo sapiens 136-141 31267354-6 2020 These results on the inhibitory activity of kukoamines A and B on Abeta and hIAPP indicate that the catechol moiety is essential for inhibition of amyloid aggregation. catechol 100-108 islet amyloid polypeptide Homo sapiens 76-81