PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30009768-4 2018 UDP-glucuronosyltransferase 1A8 (UGT1A8) is an important phase II drug-metabolizing enzymes which involved in the metabolism of catechol estrogens. catechol 128-136 UDP glucuronosyltransferase family 1 member A8 Rattus norvegicus 0-31 30009768-4 2018 UDP-glucuronosyltransferase 1A8 (UGT1A8) is an important phase II drug-metabolizing enzymes which involved in the metabolism of catechol estrogens. catechol 128-136 UDP glucuronosyltransferase family 1 member A8 Rattus norvegicus 33-39 30009768-5 2018 Here we found that the mammary nuclear factor erythroid 2-related factor 2 (NRF2) - UGT1A8 signaling was down-regulated in breast cancer rats, whereas treatment with resveratrol could upregulate the expression of NRF2 and UGT1A8, accelerate metabolic elimination of catechol estrogens, inhibit estrogen-induced DNA damage and suppress the pathological development of breast cancer. catechol 266-274 UDP glucuronosyltransferase family 1 member A8 Rattus norvegicus 84-90