PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22084166-5 2012 The FLT-3 inhibitor, SU11657, significantly reduced VEGF secretion in three of six xenograft lines and MV4;11 cells, in conjunction with inhibition of FLT-3 tyrosine phosphorylation. SU 11657 21-28 fms related receptor tyrosine kinase 3 Homo sapiens 4-9 22084166-5 2012 The FLT-3 inhibitor, SU11657, significantly reduced VEGF secretion in three of six xenograft lines and MV4;11 cells, in conjunction with inhibition of FLT-3 tyrosine phosphorylation. SU 11657 21-28 fms related receptor tyrosine kinase 3 Homo sapiens 151-156 20435347-0 2010 FLT3 and KIT mutated pediatric acute myeloid leukemia (AML) samples are sensitive in vitro to the tyrosine kinase inhibitor SU11657. SU 11657 124-131 fms related receptor tyrosine kinase 3 Homo sapiens 0-4 20435347-6 2010 FLT3 and KIT mutated samples were significantly more sensitive to SU11657 than WT KIT and FLT3 samples. SU 11657 66-73 fms related receptor tyrosine kinase 3 Homo sapiens 0-4 12515727-0 2003 A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657. SU 11657 107-114 fms related receptor tyrosine kinase 3 Homo sapiens 20-24 12515727-9 2003 SU11657, a selective, oral, multitargeted tyrosine kinase inhibitor that targets FLT3, cooperated with all-trans retinoic acid to rapidly cause regression of leukemia. SU 11657 0-7 fms related receptor tyrosine kinase 3 Homo sapiens 81-85