PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35346142-10 2022 Presumably the underlying mechanism is activation of the pregnane X receptor by flucloxacillin, which can induce cytochrome P450, uridine glucuronosyl transferase (UGT1A4) and P-glycoprotein. Floxacillin 80-94 nuclear receptor subfamily 1 group I member 2 Homo sapiens 57-76 23807564-14 2013 Furthermore, flucloxacillin was able to induce 3A4/2C8 expression mediated by PXR in a genotype dependent manner. Floxacillin 13-27 nuclear receptor subfamily 1 group I member 2 Homo sapiens 78-81 20222094-0 2010 A role for the pregnane X receptor in flucloxacillin-induced liver injury. Floxacillin 38-52 nuclear receptor subfamily 1 group I member 2 Homo sapiens 15-34 20222094-2 2010 There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist. Floxacillin 28-42 nuclear receptor subfamily 1 group I member 2 Homo sapiens 54-73 20222094-2 2010 There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist. Floxacillin 28-42 nuclear receptor subfamily 1 group I member 2 Homo sapiens 75-78 20222094-3 2010 This study was designed to investigate the relevance of PXR to flucloxacillin toxicity and to identify genes changing in expression in response to flucloxacillin. Floxacillin 63-77 nuclear receptor subfamily 1 group I member 2 Homo sapiens 56-59 20222094-5 2010 The ability of flucloxacillin to act as a PXR agonist was investigated with reporter gene experiments. Floxacillin 15-29 nuclear receptor subfamily 1 group I member 2 Homo sapiens 42-45 20222094-10 2010 Using a luciferase-everted repeat separated by 6 base pairs element construct, we confirmed that flucloxacillin was a PXR agonist. Floxacillin 97-111 nuclear receptor subfamily 1 group I member 2 Homo sapiens 118-121 20222094-11 2010 We found a difference in the distribution of a PXR polymorphism (rs3814055; C-25385T) between flucloxacillin DILI cases and controls with the CC genotype associated with an increased risk of disease (odds ratio = 3.37, 95% confidence interval = 1.55-7.30, P = 0.0023). Floxacillin 94-108 nuclear receptor subfamily 1 group I member 2 Homo sapiens 47-50 20222094-13 2010 CONCLUSION: Flucloxacillin is a PXR agonist at pharmacologically relevant concentrations, and a functionally significant upstream PXR polymorphism is a risk factor for flucloxacillin-induced DILI. Floxacillin 12-26 nuclear receptor subfamily 1 group I member 2 Homo sapiens 32-35 20222094-13 2010 CONCLUSION: Flucloxacillin is a PXR agonist at pharmacologically relevant concentrations, and a functionally significant upstream PXR polymorphism is a risk factor for flucloxacillin-induced DILI. Floxacillin 168-182 nuclear receptor subfamily 1 group I member 2 Homo sapiens 130-133 16472102-5 2006 At high concentrations, flucloxacillin activated the human Pregnane-X-Receptor, PXR, a ligand-dependent transcription factor that is the target of many drugs that induce CYP3A4, with consequences for the metabolism of other drugs. Floxacillin 24-38 nuclear receptor subfamily 1 group I member 2 Homo sapiens 59-78 16472102-5 2006 At high concentrations, flucloxacillin activated the human Pregnane-X-Receptor, PXR, a ligand-dependent transcription factor that is the target of many drugs that induce CYP3A4, with consequences for the metabolism of other drugs. Floxacillin 24-38 nuclear receptor subfamily 1 group I member 2 Homo sapiens 80-83 16472102-9 2006 These findings indicate that flucloxacillin has the potential to induce expression of both CYP3A4 as well as P-glycoprotein, most likely through activation of the nuclear hormone receptor PXR. Floxacillin 29-43 nuclear receptor subfamily 1 group I member 2 Homo sapiens 188-191