PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35346142-10	2022	Presumably the underlying mechanism is activation of the pregnane X receptor by flucloxacillin, which can induce cytochrome P450, uridine glucuronosyl transferase (UGT1A4) and P-glycoprotein.	Floxacillin	80-94	nuclear receptor subfamily 1 group I member 2	Homo sapiens	57-76	
23807564-14	2013	Furthermore, flucloxacillin was able to induce 3A4/2C8 expression mediated by PXR in a genotype dependent manner.	Floxacillin	13-27	nuclear receptor subfamily 1 group I member 2	Homo sapiens	78-81	
20222094-0	2010	A role for the pregnane X receptor in flucloxacillin-induced liver injury.	Floxacillin	38-52	nuclear receptor subfamily 1 group I member 2	Homo sapiens	15-34	
20222094-2	2010	There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist.	Floxacillin	28-42	nuclear receptor subfamily 1 group I member 2	Homo sapiens	54-73	
20222094-2	2010	There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist.	Floxacillin	28-42	nuclear receptor subfamily 1 group I member 2	Homo sapiens	75-78	
20222094-3	2010	This study was designed to investigate the relevance of PXR to flucloxacillin toxicity and to identify genes changing in expression in response to flucloxacillin.	Floxacillin	63-77	nuclear receptor subfamily 1 group I member 2	Homo sapiens	56-59	
20222094-5	2010	The ability of flucloxacillin to act as a PXR agonist was investigated with reporter gene experiments.	Floxacillin	15-29	nuclear receptor subfamily 1 group I member 2	Homo sapiens	42-45	
20222094-10	2010	Using a luciferase-everted repeat separated by 6 base pairs element construct, we confirmed that flucloxacillin was a PXR agonist.	Floxacillin	97-111	nuclear receptor subfamily 1 group I member 2	Homo sapiens	118-121	
20222094-11	2010	We found a difference in the distribution of a PXR polymorphism (rs3814055; C-25385T) between flucloxacillin DILI cases and controls with the CC genotype associated with an increased risk of disease (odds ratio = 3.37, 95% confidence interval = 1.55-7.30, P = 0.0023).	Floxacillin	94-108	nuclear receptor subfamily 1 group I member 2	Homo sapiens	47-50	
20222094-13	2010	CONCLUSION: Flucloxacillin is a PXR agonist at pharmacologically relevant concentrations, and a functionally significant upstream PXR polymorphism is a risk factor for flucloxacillin-induced DILI.	Floxacillin	12-26	nuclear receptor subfamily 1 group I member 2	Homo sapiens	32-35	
20222094-13	2010	CONCLUSION: Flucloxacillin is a PXR agonist at pharmacologically relevant concentrations, and a functionally significant upstream PXR polymorphism is a risk factor for flucloxacillin-induced DILI.	Floxacillin	168-182	nuclear receptor subfamily 1 group I member 2	Homo sapiens	130-133	
16472102-5	2006	At high concentrations, flucloxacillin activated the human Pregnane-X-Receptor, PXR, a ligand-dependent transcription factor that is the target of many drugs that induce CYP3A4, with consequences for the metabolism of other drugs.	Floxacillin	24-38	nuclear receptor subfamily 1 group I member 2	Homo sapiens	59-78	
16472102-5	2006	At high concentrations, flucloxacillin activated the human Pregnane-X-Receptor, PXR, a ligand-dependent transcription factor that is the target of many drugs that induce CYP3A4, with consequences for the metabolism of other drugs.	Floxacillin	24-38	nuclear receptor subfamily 1 group I member 2	Homo sapiens	80-83	
16472102-9	2006	These findings indicate that flucloxacillin has the potential to induce expression of both CYP3A4 as well as P-glycoprotein, most likely through activation of the nuclear hormone receptor PXR.	Floxacillin	29-43	nuclear receptor subfamily 1 group I member 2	Homo sapiens	188-191