PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3383998-16	1988	Trandolapril produced dose-related (30-1000 micrograms/kg) reductions in BP, total peripheral resistance and heart work in dogs pretreated with hydrochlorothiazide to increase plasma renin activity.	Hydrochlorothiazide	144-163	renin	Canis lupus familiaris	183-188	
234821-6	1975	Plasma renin activity, which did not change during treatment with timolol, was substantially elevated during treatment with hydrochlorothiazide.	Hydrochlorothiazide	124-143	renin	Canis lupus familiaris	7-12	
234821-8	1975	When timolol was administered concomitantly with hydrochlorothiazide, plasma renin activity was suppressed and blood pressure was significantly lowered.	Hydrochlorothiazide	49-68	renin	Canis lupus familiaris	77-82	
234821-10	1975	These observations suggest that compensatory activation of the renin-angiotensin system limits the antihypertensive activity of hydrochlorothiazide in renal hypertensive dogs and suppression of diuretic-induced renin release by timolol unmasks the antihypertensive effect of the diuretic.	Hydrochlorothiazide	128-147	renin	Canis lupus familiaris	63-68