PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34069563-5	2021	Here, for the first time, we found that the enhanced survival of cancer cells achieved by TAM was mainly mediated by CXCR4 activation from the increased secretion of CXCL12 from CSF-1 activated TAM.	tam	90-93	C-X-C motif chemokine receptor 4	Homo sapiens	117-122	
34847407-9	2022	Our findings indicate that SIRT1 in CRC induces TAM migration through the CXCR4/CXCL12 pathway, and inhibits the proliferation and activity of CD8+ T cells, resulting in promotion of CRC progression.	tam	48-51	C-X-C motif chemokine receptor 4	Homo sapiens	74-79	
30504836-6	2018	CXCR4 upregulation in radioresistant tumour ECs was highly associated with SDF-1+ TAM recruitment and M2 polarization of TAMs, which was suppressed by Trp53 deletion.	tam	82-85	C-X-C motif chemokine receptor 4	Homo sapiens	0-5	
34012800-9	2021	There are several strategies for TAM targeting and utilizing them for therapeutic purposes including limiting monocyte recruitment and localization through various pathways such as CCL2-CCR2, CSF1-CSF1R, and CXCL12-CXCR4, targeting the activation of TAMs, genetic and epigenetic reprogramming of TAMs to antitumor phenotype, and utilizing TAMs as the carrier for anti-cancer drugs.	tam	33-36	C-X-C motif chemokine receptor 4	Homo sapiens	215-220	
33123122-11	2020	Treatment of spheroids with anti-CXCR4 rescued T cell cytotoxic activity and prevented TAM polarization, likely by causing the decrease of adenosine and IL-10 production.	tam	87-90	C-X-C motif chemokine receptor 4	Homo sapiens	33-38