PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33671514-4	2021	However, the most potent regulator of PFK-1 is fructose-2,6-bisphosphate (F-2,6-BP), the level of which is strongly associated with 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase activity (PFK-2/FBPase-2, PFKFB).	fructose 2,6-diphosphate	47-72	fructose-bisphosphatase 2	Homo sapiens	201-209	
33671514-4	2021	However, the most potent regulator of PFK-1 is fructose-2,6-bisphosphate (F-2,6-BP), the level of which is strongly associated with 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase activity (PFK-2/FBPase-2, PFKFB).	fructose 2,6-diphosphate	74-82	fructose-bisphosphatase 2	Homo sapiens	201-209	
33671514-5	2021	PFK-2/FBPase-2 is a bifunctional enzyme responsible for F-2,6-BP synthesis and degradation.	fructose 2,6-diphosphate	56-64	fructose-bisphosphatase 2	Homo sapiens	6-14	
16766380-3	2006	Results from a bioinformatics analysis of genome databases suggest that very early in evolution, in a common ancestor of all extant eukaryotes, distinct genes encoding PFK-2 and FBPase-2, or related enzymes with broader substrate specificity, fused resulting in a bifunctional enzyme both domains of which had, or later acquired, specificity for fructose 2,6-bisphosphate.	fructose 2,6-diphosphate	346-371	fructose-bisphosphatase 2	Homo sapiens	178-186	
29435871-1	2018	Lymphocyte activation is associated with rapid increase of both the glycolytic activator fructose 2,6-bisphosphate (Fru-2,6-P2) and the enzyme responsible for its synthesis, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2).	fructose 2,6-diphosphate	89-114	fructose-bisphosphatase 2	Homo sapiens	234-242	
23207906-6	2013	It was counteracted by selective depletion of fructose 2,6-bisphosphate with a bisphosphatase-active kinase-deficient variant of phosphofructokinase 2/fructosebisphosphatase 2, which prevented translocation of MondoA to the nucleus and recruitment to the PTG promoter.	fructose 2,6-diphosphate	46-71	fructose-bisphosphatase 2	Homo sapiens	151-175	
22214556-4	2012	By using diverse substrates and inhibitors and a kinase-deficient bisphosphatase-active variant of the bifunctional enzyme PFK2/FBP2 (6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase), we demonstrate an essential role for fructose 2,6-bisphosphate in the induction of G6pc and other ChREBP target genes by glucose.	fructose 2,6-diphosphate	226-251	fructose-bisphosphatase 2	Homo sapiens	128-132	
20656052-9	2010	AMP and fructose-2,6-bisphosphate (Fru-2,6P(2)) are potent inhibitors of frog muscle FBPase with I(0.5) of 0.2 microM and K(i) of 114 nM, respectively.	fructose 2,6-diphosphate	8-33	fructose-bisphosphatase 2	Homo sapiens	78-91	
17374851-7	2007	This means that the GK-bound PFK-2/FBP-2 produces more of the biofactor fructose-2,6-bisphosphate, a potent activator of 6-phosphofructo-1-kinase, the committing step to glycolysis.	fructose 2,6-diphosphate	72-97	fructose-bisphosphatase 2	Homo sapiens	35-40	
11165514-0	2001	PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate.	fructose 2,6-diphosphate	61-86	fructose-bisphosphatase 2	Homo sapiens	6-14	
11522786-11	2001	The interaction between glucokinase and PFK-2/FBPase-2 may provide the rationale for recent observations of a fructose-2,6-bisphosphate level-dependent partial channeling of glycolytic intermediates between glucokinase and glycolytic enzymes.	fructose 2,6-diphosphate	110-135	fructose-bisphosphatase 2	Homo sapiens	46-54	
8395137-4	1993	The results indicate that in established lines of hepatoma cells the biochemical properties of the bifunctional enzyme, PFK-2/FBPase-2, involved in the synthesis and degradation of fructose 2,6-bisphosphate, differ from those of the enzyme from normal liver.	fructose 2,6-diphosphate	181-206	fructose-bisphosphatase 2	Homo sapiens	126-134	
34234350-2	2021	One of the rate limiting enzymes of glycolysis is 6-phosphofructo-1-kinase, which is allosterically activated by fructose 2,6-bisphosphate which in turn is produced by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2 or PFKFB).	fructose 2,6-diphosphate	113-138	fructose-bisphosphatase 2	Homo sapiens	228-236	
9119406-1	1997	6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis.	fructose 2,6-diphosphate	113-138	fructose-bisphosphatase 2	Homo sapiens	60-68