PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12604610-4	2003	A point mutation of the TOS motif also eliminates all in vitro mTOR-catalyzed 4E-BP1 phosphorylation and abolishes the raptor-dependent component of mTOR-catalyzed p70S6k phosphorylation in vitro.	tos	24-27	ribosomal protein S6 kinase B1	Homo sapiens	164-170	
15659381-2	2005	We previously identified a conserved TOR signaling (TOS) motif in the N terminus of S6K1 that is required for its mTOR-dependent activation.	tos	52-55	ribosomal protein S6 kinase B1	Homo sapiens	84-88	
15659381-3	2005	Furthermore, our data suggested that the TOS motif suppresses an inhibitory function associated with the C terminus of S6K1.	tos	41-44	ribosomal protein S6 kinase B1	Homo sapiens	119-123	
12747827-2	2003	We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1.	tos	40-43	ribosomal protein S6 kinase B1	Homo sapiens	72-76	
12747827-2	2003	We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1.	tos	40-43	ribosomal protein S6 kinase B1	Homo sapiens	131-135	
12747827-2	2003	We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1.	tos	40-43	ribosomal protein S6 kinase B1	Homo sapiens	131-135	
12747827-2	2003	We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1.	tos	141-144	ribosomal protein S6 kinase B1	Homo sapiens	72-76	
12747827-2	2003	We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1.	tos	141-144	ribosomal protein S6 kinase B1	Homo sapiens	131-135	
12747827-2	2003	We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1.	tos	141-144	ribosomal protein S6 kinase B1	Homo sapiens	131-135	
12747827-3	2003	However, it is unclear how the TOS motif in S6K1 and 4E-BP1 mediates mTOR signaling.	tos	31-34	ribosomal protein S6 kinase B1	Homo sapiens	44-48	
11967149-4	2002	RESULTS: We have identified a conserved TOR signaling (TOS) motif in the N terminus of all known S6 kinases and in the C terminus of the 4E-BPs that is crucial for phosphorylation and regulation S6K1 and 4E-BP1 activities.	tos	55-58	ribosomal protein S6 kinase B1	Homo sapiens	195-210	
11967149-5	2002	Deletion or mutations within the TOS motif significantly inhibit S6K1 activation and the phosphorylation of its hydrophobic motif, Thr389.	tos	33-36	ribosomal protein S6 kinase B1	Homo sapiens	65-69	
11967149-8	2002	Furthermore, only overexpression of S6K1 with an intact TOS motif prevents 4E-BP1 phosphorylation by a common mTOR-regulated modulator of S6K1 and 4E-BP1.	tos	56-59	ribosomal protein S6 kinase B1	Homo sapiens	36-40	
11967149-9	2002	CONCLUSIONS: S6K1 and 4E-BP1 contain a conserved five amino acid sequence (TOS motif) that is crucial for their regulation by the mTOR pathway.	tos	75-78	ribosomal protein S6 kinase B1	Homo sapiens	13-28