PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21390062-0	2011	Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis.	Deferoxamine	47-62	structural maintenance of chromosomes 1A	Homo sapiens	19-23	
21390062-0	2011	Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis.	Deferoxamine	64-67	structural maintenance of chromosomes 1A	Homo sapiens	19-23	
21390062-3	2011	Here, we studied the mechanism of DNA damage checkpoint activated by ATR-SMC1 pathway when cells are treated with desferrioxamine (DFO), a hypoxia-mimetic reagent.	Deferoxamine	114-129	structural maintenance of chromosomes 1A	Homo sapiens	73-77	
21390062-3	2011	Here, we studied the mechanism of DNA damage checkpoint activated by ATR-SMC1 pathway when cells are treated with desferrioxamine (DFO), a hypoxia-mimetic reagent.	Deferoxamine	131-134	structural maintenance of chromosomes 1A	Homo sapiens	73-77	
21390062-4	2011	We show that DFO treatment induces phosphorylation of SMC1 at Ser966, NBS1 at Ser343, Chk1 at Ser317, Chk2 at Thr68, and p53 at Ser15.	Deferoxamine	13-16	structural maintenance of chromosomes 1A	Homo sapiens	54-58	
21390062-5	2011	Among these sites, phosphorylation of SMC1, NBS1, and Chk1 by DFO are mediated by ATR as it is greatly reduced in both ATR-deficient human fibroblasts and HCT116 human colon cancer cells in which ATR is heterozygously mutated, whereas these proteins are phosphorylated in cells deficient for ATM and DNA-PKcs.	Deferoxamine	62-65	structural maintenance of chromosomes 1A	Homo sapiens	38-42	
21390062-7	2011	Expression of SMC1 S966A in which Ser966 is substituted to Ala attenuates apoptosis and phosphorylation of Chk1 at Ser317 after DFO treatment, although levels of HIF1alpha are not significantly changed.	Deferoxamine	128-131	structural maintenance of chromosomes 1A	Homo sapiens	14-18	
21390062-8	2011	These results suggest that DFO induces apoptosis through the ATR-SMC1 arm of the pathway.	Deferoxamine	27-30	structural maintenance of chromosomes 1A	Homo sapiens	65-69