PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22261759-0	2012	Elevated plasma succinate in PTEN, SDHB, and SDHD mutation-positive individuals.	Succinic Acid	16-25	phosphatase and tensin homolog	Homo sapiens	29-33	
22261759-2	2012	We hypothesized that succinate accumulation may be common among individuals with SDH variants/mutations and those with PTEN mutations.	Succinic Acid	21-30	phosphatase and tensin homolog	Homo sapiens	119-123	
22261759-5	2012	RESULTS: Elevated plasma succinate was observed in 13/21 (62%) individuals with germline PTEN, SDHB, or SDHD mutations as compared with 5/32 (16%) controls (P < 0.001), in 10/15 (67%) individuals with pathogenic PTEN mutations but in <20% of mutation-negative individuals meeting identical criteria, and in individuals with mutations in SDHB (1/1, 100%) and SDHD (2/5, 40%).	Succinic Acid	25-34	phosphatase and tensin homolog	Homo sapiens	89-93	
30037119-0	2018	Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1alpha Upregulation in PTEN Negative Prostate Cancer Cells.	Succinic Acid	0-9	phosphatase and tensin homolog	Homo sapiens	118-122	
30037119-6	2018	Using high-resolution respirometry analysis, we observed that ROUTINE respiration in viable cells and succinate-supported respiration in permeabilized cells was higher in cells lacking the tumor suppressor phosphatase and tensin-homolog deleted on chromosome 10 (PTEN), which is frequently lost in PCa.	Succinic Acid	102-111	phosphatase and tensin homolog	Homo sapiens	263-267	
30037119-7	2018	In addition, loss of PTEN was associated with increased intracellular succinate accumulation and higher expression of NaDC3.	Succinic Acid	70-79	phosphatase and tensin homolog	Homo sapiens	21-25	
30037119-11	2018	In conclusion, our data provide evidence that loss of PTEN is associated with increased succinate accumulation and enhanced succinate-supported respiration, which cannot be overcome by inhibiting the succinate transporter NaDC3 alone.	Succinic Acid	88-97	phosphatase and tensin homolog	Homo sapiens	54-58	
30037119-11	2018	In conclusion, our data provide evidence that loss of PTEN is associated with increased succinate accumulation and enhanced succinate-supported respiration, which cannot be overcome by inhibiting the succinate transporter NaDC3 alone.	Succinic Acid	124-133	phosphatase and tensin homolog	Homo sapiens	54-58	
22261759-5	2012	RESULTS: Elevated plasma succinate was observed in 13/21 (62%) individuals with germline PTEN, SDHB, or SDHD mutations as compared with 5/32 (16%) controls (P < 0.001), in 10/15 (67%) individuals with pathogenic PTEN mutations but in <20% of mutation-negative individuals meeting identical criteria, and in individuals with mutations in SDHB (1/1, 100%) and SDHD (2/5, 40%).	Succinic Acid	25-34	phosphatase and tensin homolog	Homo sapiens	215-219	
22261759-6	2012	CONCLUSION: Our data suggest that mutations in PTEN, SDHB, and SDHD reduce catalytic activity of succinate dehydrogenase, resulting in succinate accumulation, and identify a common biochemical alteration in these two patient populations (PTEN and SDHx mutation positive individuals).	Succinic Acid	97-106	phosphatase and tensin homolog	Homo sapiens	47-51	
22261759-6	2012	CONCLUSION: Our data suggest that mutations in PTEN, SDHB, and SDHD reduce catalytic activity of succinate dehydrogenase, resulting in succinate accumulation, and identify a common biochemical alteration in these two patient populations (PTEN and SDHx mutation positive individuals).	Succinic Acid	97-106	phosphatase and tensin homolog	Homo sapiens	238-242