PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30037119-0 2018 Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1alpha Upregulation in PTEN Negative Prostate Cancer Cells. Succinic Acid 0-9 phosphatase and tensin homolog Homo sapiens 118-122 30037119-6 2018 Using high-resolution respirometry analysis, we observed that ROUTINE respiration in viable cells and succinate-supported respiration in permeabilized cells was higher in cells lacking the tumor suppressor phosphatase and tensin-homolog deleted on chromosome 10 (PTEN), which is frequently lost in PCa. Succinic Acid 102-111 phosphatase and tensin homolog Homo sapiens 263-267 30037119-7 2018 In addition, loss of PTEN was associated with increased intracellular succinate accumulation and higher expression of NaDC3. Succinic Acid 70-79 phosphatase and tensin homolog Homo sapiens 21-25 30037119-11 2018 In conclusion, our data provide evidence that loss of PTEN is associated with increased succinate accumulation and enhanced succinate-supported respiration, which cannot be overcome by inhibiting the succinate transporter NaDC3 alone. Succinic Acid 88-97 phosphatase and tensin homolog Homo sapiens 54-58 30037119-11 2018 In conclusion, our data provide evidence that loss of PTEN is associated with increased succinate accumulation and enhanced succinate-supported respiration, which cannot be overcome by inhibiting the succinate transporter NaDC3 alone. Succinic Acid 124-133 phosphatase and tensin homolog Homo sapiens 54-58 22261759-5 2012 RESULTS: Elevated plasma succinate was observed in 13/21 (62%) individuals with germline PTEN, SDHB, or SDHD mutations as compared with 5/32 (16%) controls (P < 0.001), in 10/15 (67%) individuals with pathogenic PTEN mutations but in <20% of mutation-negative individuals meeting identical criteria, and in individuals with mutations in SDHB (1/1, 100%) and SDHD (2/5, 40%). Succinic Acid 25-34 phosphatase and tensin homolog Homo sapiens 215-219 22261759-0 2012 Elevated plasma succinate in PTEN, SDHB, and SDHD mutation-positive individuals. Succinic Acid 16-25 phosphatase and tensin homolog Homo sapiens 29-33 22261759-2 2012 We hypothesized that succinate accumulation may be common among individuals with SDH variants/mutations and those with PTEN mutations. Succinic Acid 21-30 phosphatase and tensin homolog Homo sapiens 119-123 22261759-5 2012 RESULTS: Elevated plasma succinate was observed in 13/21 (62%) individuals with germline PTEN, SDHB, or SDHD mutations as compared with 5/32 (16%) controls (P < 0.001), in 10/15 (67%) individuals with pathogenic PTEN mutations but in <20% of mutation-negative individuals meeting identical criteria, and in individuals with mutations in SDHB (1/1, 100%) and SDHD (2/5, 40%). Succinic Acid 25-34 phosphatase and tensin homolog Homo sapiens 89-93 22261759-6 2012 CONCLUSION: Our data suggest that mutations in PTEN, SDHB, and SDHD reduce catalytic activity of succinate dehydrogenase, resulting in succinate accumulation, and identify a common biochemical alteration in these two patient populations (PTEN and SDHx mutation positive individuals). Succinic Acid 97-106 phosphatase and tensin homolog Homo sapiens 47-51 22261759-6 2012 CONCLUSION: Our data suggest that mutations in PTEN, SDHB, and SDHD reduce catalytic activity of succinate dehydrogenase, resulting in succinate accumulation, and identify a common biochemical alteration in these two patient populations (PTEN and SDHx mutation positive individuals). Succinic Acid 97-106 phosphatase and tensin homolog Homo sapiens 238-242