PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22322891-10 2012 Inhibition of mt-HK II by glucose-6-phosphate retards the mitochondria to react with 3-BrPA. Glucose-6-Phosphate 26-45 hexokinase 2 Homo sapiens 17-22 22382780-5 2012 At its mitochondrial location HK2 binds at/near the protein VDAC (voltage dependent anion channel), escapes inhibition by its product glucose-6-phosphate, and gains access to mitochondrial produced ATP. Glucose-6-Phosphate 134-153 hexokinase 2 Homo sapiens 30-33 7883122-2 1995 Since defects involving glucose transport and/or its phosphorylation to glucose-6-phosphate are present in muscle of insulin-resistant humans, HKII should be viewed as a candidate gene for inherited insulin resistance and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM). Glucose-6-Phosphate 72-91 hexokinase 2 Homo sapiens 143-147 16892090-5 2006 The abundant amounts of HK II bind both the ATP and the incoming glucose producing the product glucose-6-phosphate, also at an elevated rate. Glucose-6-Phosphate 95-114 hexokinase 2 Homo sapiens 24-29 9519744-2 1998 It has been suggested that impaired glucose phosphorylation to glucose-6-phosphate, catalyzed in muscle by hexokinase (HK)II, may contribute to this insulin resistance. Glucose-6-Phosphate 63-82 hexokinase 2 Homo sapiens 119-124 8721778-1 1996 UNLABELLED: Hexokinase II (HKII) plays a central role in the intracellular metabolism of glucose in skeletal muscle, catalysing the phosphorylation of glucose to glucose 6-phosphate. Glucose-6-Phosphate 162-181 hexokinase 2 Homo sapiens 12-25 8721778-1 1996 UNLABELLED: Hexokinase II (HKII) plays a central role in the intracellular metabolism of glucose in skeletal muscle, catalysing the phosphorylation of glucose to glucose 6-phosphate. Glucose-6-Phosphate 162-181 hexokinase 2 Homo sapiens 27-31 8786021-1 1995 In muscle, hexokinase II (HK2) regulates phosphorylation of glucose to glucose 6-phosphate, which has been reported to be impaired in patients with non-insulin-dependent diabetes mellitus (NIDDM). Glucose-6-Phosphate 71-90 hexokinase 2 Homo sapiens 26-29 7883123-2 1995 Since reduced insulin-stimulated glucose uptake and reduced glucose-6-phosphate content in muscle have been demonstrated in pre-non-insulin-dependent diabetes mellitus (pre-NIDDM) and NIDDM subjects, we have examined the coding region of the HKII gene in NIDDM patients to determine whether these patients show genetic polymorphisms that are associated with or contribute to the disease. Glucose-6-Phosphate 60-79 hexokinase 2 Homo sapiens 242-246 29291405-5 2018 Also we found that NQO1 depletion significantly decreased the gene expression levels of hexokinase II (HKII), a key mediator of aerobic glycolysis responsible for the transformation of glucose into glucose-6-phosphate. Glucose-6-Phosphate 198-217 hexokinase 2 Homo sapiens 88-101 31212816-3 2019 Hexokinase 2 (HK2) converts glucose to glucose-6-phosphate, the first committed step in glucose metabolism. Glucose-6-Phosphate 39-58 hexokinase 2 Homo sapiens 0-12 31212816-3 2019 Hexokinase 2 (HK2) converts glucose to glucose-6-phosphate, the first committed step in glucose metabolism. Glucose-6-Phosphate 39-58 hexokinase 2 Homo sapiens 14-17 31354221-6 2019 Results: It was determined that HKII could not only transform glucose into glucose-6-phosphate, but also transfer the phosphate group of ATP onto PDHA1. Glucose-6-Phosphate 75-94 hexokinase 2 Homo sapiens 32-36 29298880-4 2018 Here, we report the structure of HK2 in complex with glucose and glucose-6-phosphate (G6P). Glucose-6-Phosphate 65-84 hexokinase 2 Homo sapiens 33-36 29298880-4 2018 Here, we report the structure of HK2 in complex with glucose and glucose-6-phosphate (G6P). Glucose-6-Phosphate 86-89 hexokinase 2 Homo sapiens 33-36 29247711-3 2018 Hexokinase 2 (HK2) phosphorylates glucose to generate glucose-6-phosphate, the rate-limiting step in glycolysis. Glucose-6-Phosphate 54-73 hexokinase 2 Homo sapiens 0-12 29247711-3 2018 Hexokinase 2 (HK2) phosphorylates glucose to generate glucose-6-phosphate, the rate-limiting step in glycolysis. Glucose-6-Phosphate 54-73 hexokinase 2 Homo sapiens 14-17 29291405-5 2018 Also we found that NQO1 depletion significantly decreased the gene expression levels of hexokinase II (HKII), a key mediator of aerobic glycolysis responsible for the transformation of glucose into glucose-6-phosphate. Glucose-6-Phosphate 198-217 hexokinase 2 Homo sapiens 103-107 25204670-5 2015 Major determinants of HK2 dissociation are the elevated glucose-6-phosphate concentrations and decreased pH in ischaemia. Glucose-6-Phosphate 56-75 hexokinase 2 Homo sapiens 22-25 28980855-4 2018 The autophagic degradation of HK2 (hexokinase 2), a crucial glycolytic enzyme catalyzing the conversion of glucose to glucose-6-phosphate, was found to be involved in the regulation of glycolysis by autophagy. Glucose-6-Phosphate 118-137 hexokinase 2 Homo sapiens 30-33 28980855-4 2018 The autophagic degradation of HK2 (hexokinase 2), a crucial glycolytic enzyme catalyzing the conversion of glucose to glucose-6-phosphate, was found to be involved in the regulation of glycolysis by autophagy. Glucose-6-Phosphate 118-137 hexokinase 2 Homo sapiens 35-47 26054020-7 2015 MicroRNA-199a-5p directly targets the 3"-untranslated region of hexokinase 2 (HK2), an enzyme that catalyzes the irreversible first step of glycolysis, thereby suppressing glucose consumption, lactate production, cellular glucose-6-phosphate and adenosine triphosphate levels, cell proliferation, and tumorigenesis of liver cancer cells. Glucose-6-Phosphate 222-241 hexokinase 2 Homo sapiens 64-76 26054020-7 2015 MicroRNA-199a-5p directly targets the 3"-untranslated region of hexokinase 2 (HK2), an enzyme that catalyzes the irreversible first step of glycolysis, thereby suppressing glucose consumption, lactate production, cellular glucose-6-phosphate and adenosine triphosphate levels, cell proliferation, and tumorigenesis of liver cancer cells. Glucose-6-Phosphate 222-241 hexokinase 2 Homo sapiens 78-81 26116768-4 2015 In this study, we showed that elevated Hexokinase-2 (HK2) expression, which catalyzes the first essential step of glucose metabolism by conversion of glucose into glucose-6-phosphate, was induced by activated PI3K/Akt signaling. Glucose-6-Phosphate 163-182 hexokinase 2 Homo sapiens 39-51 26116768-4 2015 In this study, we showed that elevated Hexokinase-2 (HK2) expression, which catalyzes the first essential step of glucose metabolism by conversion of glucose into glucose-6-phosphate, was induced by activated PI3K/Akt signaling. Glucose-6-Phosphate 163-182 hexokinase 2 Homo sapiens 53-56 24577087-7 2014 Increasing glucose metabolism by expressing hexokinase2 (HK2), which converts glucose to glucose-6-phosphate (G6P), favors escape from OIS. Glucose-6-Phosphate 89-108 hexokinase 2 Homo sapiens 44-55 24577087-7 2014 Increasing glucose metabolism by expressing hexokinase2 (HK2), which converts glucose to glucose-6-phosphate (G6P), favors escape from OIS. Glucose-6-Phosphate 89-108 hexokinase 2 Homo sapiens 57-60 24577087-7 2014 Increasing glucose metabolism by expressing hexokinase2 (HK2), which converts glucose to glucose-6-phosphate (G6P), favors escape from OIS. Glucose-6-Phosphate 110-113 hexokinase 2 Homo sapiens 44-55 24577087-7 2014 Increasing glucose metabolism by expressing hexokinase2 (HK2), which converts glucose to glucose-6-phosphate (G6P), favors escape from OIS. Glucose-6-Phosphate 110-113 hexokinase 2 Homo sapiens 57-60