PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16787225-1 2006 Glucokinase (GK) is a molecular sensor that regulates glucose induced insulin secretion in pancreatic beta-cells and glucose homeostasis in the liver via catalysis of glucose to glucose-6-phosphate. Glucose-6-Phosphate 178-197 glucokinase Homo sapiens 0-11 16787225-1 2006 Glucokinase (GK) is a molecular sensor that regulates glucose induced insulin secretion in pancreatic beta-cells and glucose homeostasis in the liver via catalysis of glucose to glucose-6-phosphate. Glucose-6-Phosphate 178-197 glucokinase Homo sapiens 13-15 16403021-0 2006 The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism. Glucose-6-Phosphate 12-31 glucokinase Homo sapiens 60-71 16403021-8 2006 The high control strength of glucokinase on glycogenic flux is explained by its concentration control coefficient on Glc6P and the high control strength of Glc6P on glycogen synthesis. Glucose-6-Phosphate 117-122 glucokinase Homo sapiens 29-40 16403021-8 2006 The high control strength of glucokinase on glycogenic flux is explained by its concentration control coefficient on Glc6P and the high control strength of Glc6P on glycogen synthesis. Glucose-6-Phosphate 156-161 glucokinase Homo sapiens 29-40 16403021-9 2006 It is suggested that the regulatory strength of pharmacological glucokinase activators on glycogen metabolism can be predicted from their effect on the Glc6P content. Glucose-6-Phosphate 152-157 glucokinase Homo sapiens 64-75 12519761-0 2003 Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase. Glucose-6-Phosphate 0-19 glucokinase Homo sapiens 55-66 14975750-2 2004 The ubiquitous mammalian ATP-dependent hexokinases I-III and hexokinase IV, also termed glucokinase, initiate the process by phosphorylating glucose to glucose-6-phosphate. Glucose-6-Phosphate 152-171 glucokinase Homo sapiens 88-99 15667334-1 2005 The enzyme GK (glucokinase), which phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor of insulin-producing beta-cells. Glucose-6-Phosphate 66-85 glucokinase Homo sapiens 11-13 15667334-1 2005 The enzyme GK (glucokinase), which phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor of insulin-producing beta-cells. Glucose-6-Phosphate 66-85 glucokinase Homo sapiens 15-26 12829248-6 2003 The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I). Glucose-6-Phosphate 15-22 glucokinase Homo sapiens 130-141 12829248-6 2003 The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I). Glucose-6-Phosphate 15-22 glucokinase Homo sapiens 143-145 12829248-6 2003 The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I). Glucose-6-Phosphate 85-92 glucokinase Homo sapiens 130-141 12829248-6 2003 The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I). Glucose-6-Phosphate 85-92 glucokinase Homo sapiens 143-145 12765941-7 2003 The inhibition of glycogenolysis and inactivation of phosphorylase-a caused by 10 mmol/l glucose can be at least in part counteracted by inhibition of glucokinase with 5-thioglucose, which lowers G6P. Glucose-6-Phosphate 196-199 glucokinase Homo sapiens 151-162 12519761-4 2003 Our results indicate that the gluconeogenic pathway and the glucokinase-mediated phosphorylation of glucose deliver their common product to the same Glc-6-P pool, which is accessible to liver GS. Glucose-6-Phosphate 149-156 glucokinase Homo sapiens 60-71 10455119-2 1999 In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels. Glucose-6-Phosphate 99-118 glucokinase Homo sapiens 15-26 11594461-1 2001 Glucokinase catalyzes phosphoryl group transfer from ATP to glucose to form glucose-6-phosphate in the first step of cellular metabolism. Glucose-6-Phosphate 76-95 glucokinase Homo sapiens 0-11 10455119-2 1999 In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels. Glucose-6-Phosphate 99-118 glucokinase Homo sapiens 28-30 9684361-12 1998 Little inhibition was observed with glucose 6-phosphate (up to 15 mM) at pH 8.0; however, at pH 7.0 glucokinase activity was inhibited 30-50% by physiological concentrations of glucose 6-phosphate. Glucose-6-Phosphate 177-196 glucokinase Homo sapiens 100-111 9895293-6 1999 The stimulation of flux through glucokinase by low concentrations of fructose decreased the proportion of glucose phosphorylated, which was cycled between glucose and glucose 6-phosphate, and increased the proportion that was glycolysed. Glucose-6-Phosphate 167-186 glucokinase Homo sapiens 32-43 9895293-7 1999 The method described for maintaining the stimulation of glucose phosphorylation by isolated hepatocytes over prolonged incubation periods is especially suited to the further study of the control of glucokinase activity, in particular how the variation of flux through glucokinase affects the flux through all the pathways that utilize the product, glucose 6-phosphate. Glucose-6-Phosphate 348-367 glucokinase Homo sapiens 268-279 9271087-9 1997 The glucose 6-phosphate content correlated with the free glucokinase activity. Glucose-6-Phosphate 4-23 glucokinase Homo sapiens 57-68 9271087-11 1997 The suppression of glucose 6-phosphate at high glucose concentration (15-35 mM) could be explained by the low activity of free glucokinase. Glucose-6-Phosphate 19-38 glucokinase Homo sapiens 127-138 7614462-9 1995 Tumor cell glucokinase activity has been characterized by its high Km for glucose (8-11.8 mM); inhibition by the specific glucokinase inhibitor, mannoheptulose (I50, 12.5 mM); and lack of inhibition by 10 mM glucose-6-phosphate. Glucose-6-Phosphate 208-227 glucokinase Homo sapiens 11-22 8798601-0 1996 Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase. Glucose-6-Phosphate 0-19 glucokinase Homo sapiens 32-43 8798601-10 1996 We conclude that Glu-6-P produced by overexpressed glucokinase is glycogenic because it effectively promotes activation of glycogen synthase. Glucose-6-Phosphate 17-24 glucokinase Homo sapiens 51-62 8679719-4 1996 Glucose 6-phosphate decreased, modestly but significantly, B-cell glucokinase activity, such an inhibitory action being of the non-competitive type. Glucose-6-Phosphate 0-19 glucokinase Homo sapiens 66-77 8344989-0 1993 Interaction of facilitative glucose transporter with glucokinase and its modulation by ADP and glucose-6-phosphate. Glucose-6-Phosphate 95-114 glucokinase Homo sapiens 53-64 7869925-8 1995 Glucose phosphorylation, evaluated by measuring the rate of glucose-6-phosphate formation in a fluorimetric assay, indicated that glucokinase activity had a maximum (Vmax) of 7.97 +/- 0.94 nmol/microgram DNA/h and a Km of 8.3 +/- 0.9 mmol/L (mean +/- SE, n = 8). Glucose-6-Phosphate 60-79 glucokinase Homo sapiens 130-141 7955370-3 1994 In the method used here, glucokinase and an ATP-regenerating system efficiently convert glucose to the unreactive compound, glucose 6-phosphate, making the method selective for 1,5-AG. Glucose-6-Phosphate 124-143 glucokinase Homo sapiens 25-36 7983782-1 1994 Glucokinase is a key enzyme of glucose metabolism that phosphorylates glucose to glucose-6-phosphate (G-6-P). Glucose-6-Phosphate 81-100 glucokinase Homo sapiens 0-11 7983782-1 1994 Glucokinase is a key enzyme of glucose metabolism that phosphorylates glucose to glucose-6-phosphate (G-6-P). Glucose-6-Phosphate 102-107 glucokinase Homo sapiens 0-11 8280078-16 1993 Since 2-3H is lost during conversion of glucose 6-phosphate into fructose 6-phosphate, substrate-induced translocation of glucokinase from a Mg(2+)-dependent binding site to an alternative site might favour the partitioning of glucose 6-phosphate towards glycogen, as opposed to phosphoglucoisomerase. Glucose-6-Phosphate 40-59 glucokinase Homo sapiens 122-133 8280078-16 1993 Since 2-3H is lost during conversion of glucose 6-phosphate into fructose 6-phosphate, substrate-induced translocation of glucokinase from a Mg(2+)-dependent binding site to an alternative site might favour the partitioning of glucose 6-phosphate towards glycogen, as opposed to phosphoglucoisomerase. Glucose-6-Phosphate 227-246 glucokinase Homo sapiens 122-133 30949058-4 2019 Once inside, glucose is phosphorylated to glucose-6-phosphate by GCK in a reaction that is dependent on glucose throughout the physiological range of concentrations, is irreversible, and not product inhibited. Glucose-6-Phosphate 42-61 glucokinase Homo sapiens 65-68 1832811-7 1991 The decreases in activities of phosphoglucomutase and glucokinase reduced a level of glucose 6-phosphate, which suppressed the supply of NADPH in pentose cycle, while the NADPH was consuming well for detoxification of endogenous lipid peroxides. Glucose-6-Phosphate 85-104 glucokinase Homo sapiens 54-65 2159682-6 1990 By this formula we evaluated the hepatic activities of glucose-6-phosphatase and glucokinase (which roughly reflect hepatic glucose production and uptake, respectively), i.e. the two enzymes that catalyze the cycle between glucose-6-phosphate (glucose-6-P) and glucose. Glucose-6-Phosphate 223-242 glucokinase Homo sapiens 81-92 2159682-6 1990 By this formula we evaluated the hepatic activities of glucose-6-phosphatase and glucokinase (which roughly reflect hepatic glucose production and uptake, respectively), i.e. the two enzymes that catalyze the cycle between glucose-6-phosphate (glucose-6-P) and glucose. Glucose-6-Phosphate 244-255 glucokinase Homo sapiens 81-92 31372018-3 2019 Glucokinase is predominantly expressed in pancreatic beta cells and catalyzes the phosphorylation of glucose to glucose-6-phosphate. Glucose-6-Phosphate 112-131 glucokinase Homo sapiens 0-11 30983961-3 2019 GK catalyzes the phosphorylation of glucose to glucose-6-phosphate (G-6P), and its activity and subcellular localization are regulated by GKRP. Glucose-6-Phosphate 47-66 glucokinase Homo sapiens 0-2 30983961-3 2019 GK catalyzes the phosphorylation of glucose to glucose-6-phosphate (G-6P), and its activity and subcellular localization are regulated by GKRP. Glucose-6-Phosphate 68-72 glucokinase Homo sapiens 0-2 3043440-11 1988 It is also easy to imagine that in diabetes when the islets are chronically exposed to high glucose that, as a result of the content of the high Km glucokinase in the islet (Meglasson and Matschinsky, 1986), higher concentrations of glucose 6-phosphate may be achieved. Glucose-6-Phosphate 233-252 glucokinase Homo sapiens 148-159 196677-4 1977 Solubilizations by ATP and glucose-6-phosphate differ in their sensitivity to temperature changes; they are relatively specific for glucokinase as compared to solubilization by detergent (Triton X 100). Glucose-6-Phosphate 27-46 glucokinase Homo sapiens 132-143 28655753-3 2017 Glucokinase produces glucose 6-phosphate (G-6-P) in an irreversible reaction that determines glycolytic flux. Glucose-6-Phosphate 21-40 glucokinase Homo sapiens 0-11 29885360-1 2018 Glucokinase (GK) is an enzyme that catalyzes the ATP-dependent phosphorylation of glucose to form glucose-6-phosphate, and it is a tightly regulated checkpoint in glucose homeostasis. Glucose-6-Phosphate 98-117 glucokinase Homo sapiens 0-11 29885360-1 2018 Glucokinase (GK) is an enzyme that catalyzes the ATP-dependent phosphorylation of glucose to form glucose-6-phosphate, and it is a tightly regulated checkpoint in glucose homeostasis. Glucose-6-Phosphate 98-117 glucokinase Homo sapiens 13-15 28655753-3 2017 Glucokinase produces glucose 6-phosphate (G-6-P) in an irreversible reaction that determines glycolytic flux. Glucose-6-Phosphate 42-47 glucokinase Homo sapiens 0-11 24056026-1 2014 Glucokinase (GK), an enzyme that phosphorylates glucose to form glucose-6-phosphate, has a role in regulating insulin secretion and proliferation in beta cells. Glucose-6-Phosphate 64-83 glucokinase Homo sapiens 0-11 26299854-2 2015 Glucokinase (GK), an enzyme that catalyzes the conversion of glucose to glucose-6-phosphate in pancreatic ss-cells, liver hepatocytes, specific hypothalamic neurons, and intestine enterocytes, is a key regulator of glucose homeostasis. Glucose-6-Phosphate 72-91 glucokinase Homo sapiens 0-11 26299854-2 2015 Glucokinase (GK), an enzyme that catalyzes the conversion of glucose to glucose-6-phosphate in pancreatic ss-cells, liver hepatocytes, specific hypothalamic neurons, and intestine enterocytes, is a key regulator of glucose homeostasis. Glucose-6-Phosphate 72-91 glucokinase Homo sapiens 13-15 24447076-3 2014 The kinetics of pure GK showed enzyme activity of 0.423+-0.02 microM glucose-6-phosphate (G6P)/mL/Min and Km value of 6.66+-0.02 microM. Glucose-6-Phosphate 69-88 glucokinase Homo sapiens 21-23 24056026-1 2014 Glucokinase (GK), an enzyme that phosphorylates glucose to form glucose-6-phosphate, has a role in regulating insulin secretion and proliferation in beta cells. Glucose-6-Phosphate 64-83 glucokinase Homo sapiens 13-15 24696842-1 2014 OBJECTIVES: Glucokinase encoded by GCK is a key enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucose-6-Phosphate 102-121 glucokinase Homo sapiens 12-23 24696842-1 2014 OBJECTIVES: Glucokinase encoded by GCK is a key enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucose-6-Phosphate 102-121 glucokinase Homo sapiens 35-38 24226772-2 2013 Glucokinase (GK), a key enzyme that regulates glucose homeostasis, converts glucose to glucose-6-phosphate in pancreatic beta-cells, liver hepatocytes, specific hypothalamic neurons, and gut enterocytes. Glucose-6-Phosphate 87-106 glucokinase Homo sapiens 0-11 25052034-2 2014 Conversion of glucose to glucose-6-phosphate by GK promotes glycogen synthesis in liver hepatocytes, and insulin release in the pancreatic beta-cells. Glucose-6-Phosphate 25-44 glucokinase Homo sapiens 48-50 24226772-2 2013 Glucokinase (GK), a key enzyme that regulates glucose homeostasis, converts glucose to glucose-6-phosphate in pancreatic beta-cells, liver hepatocytes, specific hypothalamic neurons, and gut enterocytes. Glucose-6-Phosphate 87-106 glucokinase Homo sapiens 13-15 23573289-2 2013 In the liver, phosphorylation of glucose to glucose-6-phosphate by GCK is the first step for both glycolysis and glycogen synthesis. Glucose-6-Phosphate 44-63 glucokinase Homo sapiens 67-70 23476789-1 2013 Glucokinase (GK) is the predominant hexokinase that acts as glucose sensor and catalyses the formation of Glucose-6-phosphate. Glucose-6-Phosphate 106-125 glucokinase Homo sapiens 0-11 23476789-1 2013 Glucokinase (GK) is the predominant hexokinase that acts as glucose sensor and catalyses the formation of Glucose-6-phosphate. Glucose-6-Phosphate 106-125 glucokinase Homo sapiens 13-15 22107947-3 2012 Mammalian glucokinase is subject to homotropic allosteric regulation by glucose-the steady-state velocity of glucose-6-phosphate production is not hyperbolic, but instead displays a sigmoidal response to increasing glucose concentrations. Glucose-6-Phosphate 109-128 glucokinase Homo sapiens 10-21 23149230-1 2012 Glucokinase is a key enzyme in glucose homeostasis since it phosphorylates glucose to give glucose-6-phosphate, which is the first step in glycolysis. Glucose-6-Phosphate 91-110 glucokinase Homo sapiens 0-11 19747136-2 2009 Glucokinase (GK) is a member of hexokinase family of enzymes that are responsible for the phosphorylation of glucose to glucose-6-phosphate for further utilization in cells. Glucose-6-Phosphate 120-139 glucokinase Homo sapiens 0-11 19747136-2 2009 Glucokinase (GK) is a member of hexokinase family of enzymes that are responsible for the phosphorylation of glucose to glucose-6-phosphate for further utilization in cells. Glucose-6-Phosphate 120-139 glucokinase Homo sapiens 13-15 22101819-1 2011 Glucokinase (GK) catalyses the formation of glucose 6-phosphate from glucose and ATP. Glucose-6-Phosphate 44-63 glucokinase Homo sapiens 0-11 22101819-1 2011 Glucokinase (GK) catalyses the formation of glucose 6-phosphate from glucose and ATP. Glucose-6-Phosphate 44-63 glucokinase Homo sapiens 13-15 21490074-1 2011 BACKGROUND/AIMS: Glucokinase (GCK) phosphorylates glucose to form glucose 6-phosphate and thereby regulates hepatic glucose disposal and activates hepatic lipogenesis. Glucose-6-Phosphate 66-85 glucokinase Homo sapiens 17-28 21490074-1 2011 BACKGROUND/AIMS: Glucokinase (GCK) phosphorylates glucose to form glucose 6-phosphate and thereby regulates hepatic glucose disposal and activates hepatic lipogenesis. Glucose-6-Phosphate 66-85 glucokinase Homo sapiens 30-33 20977462-11 2010 Furthermore, curcumin stimulated glucokinase activity, increasing conversion of glucose to G-6-P. Glucose-6-Phosphate 91-96 glucokinase Homo sapiens 33-44 19520181-1 2009 Glucokinase is a member of the hexokinase family of enzymes that are responsible for the phosphorylation of glucose to glucose-6-phosphate for further utilization in cells. Glucose-6-Phosphate 119-138 glucokinase Homo sapiens 0-11 18651836-2 2008 It is regulated in part by the increase in blood-glucose concentration in the portal vein, which activates glucokinase, the first enzyme in the pathway, causing an increase in the concentration of glucose 6-P (glucose 6-phosphate), which modulates the phosphorylation state of downstream enzymes by acting synergistically with other allosteric effectors. Glucose-6-Phosphate 197-208 glucokinase Homo sapiens 107-118 18651836-2 2008 It is regulated in part by the increase in blood-glucose concentration in the portal vein, which activates glucokinase, the first enzyme in the pathway, causing an increase in the concentration of glucose 6-P (glucose 6-phosphate), which modulates the phosphorylation state of downstream enzymes by acting synergistically with other allosteric effectors. Glucose-6-Phosphate 210-229 glucokinase Homo sapiens 107-118 18651836-7 2008 The elevated glucose 6-P concentration, consequent to glucokinase activation, has a synergistic effect with glucose in promoting dephosphorylation (inactivation) of glycogen phosphorylase and inducing dephosphorylation (activation) of glycogen synthase. Glucose-6-Phosphate 13-24 glucokinase Homo sapiens 54-65 17956314-1 2007 GK (glucokinase) catalyses the phosphorylation of glucose to glucose 6-phosphate in glucosensitive cells. Glucose-6-Phosphate 61-80 glucokinase Homo sapiens 4-15 19669468-6 2006 The paper describes the glucose sensing mechanism via the complex dynamics of the key enzyme glucokinase, which controls the first step in glucose metabolism: phosphorylation of glucose to glucose-6-phosphate. Glucose-6-Phosphate 189-208 glucokinase Homo sapiens 93-104