PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25210004-1 2014 Further chemical optimization of the halopemide-derived family of dual phospholipase D1/2 (PLD1/2) inhibitors afforded ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM; cellular PLD2, IC50 =360 nM). VU0468809 126-135 phospholipase D1 Homo sapiens 71-89 25210004-1 2014 Further chemical optimization of the halopemide-derived family of dual phospholipase D1/2 (PLD1/2) inhibitors afforded ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM; cellular PLD2, IC50 =360 nM). VU0468809 126-135 phospholipase D1 Homo sapiens 91-97 25210004-1 2014 Further chemical optimization of the halopemide-derived family of dual phospholipase D1/2 (PLD1/2) inhibitors afforded ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM; cellular PLD2, IC50 =360 nM). VU0468809 126-135 phospholipase D1 Homo sapiens 91-95