PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29854096-5	2018	The effects of cafestol on mitogen-activated protein kinases (MAPK), heme oxygenase-1 (HO-1), and sirtuin 1 (Sirt1) signaling pathways were examined using Western blotting and specific inhibitors.	cafestol	15-23	heme oxygenase 1	Homo sapiens	69-85	
29854096-8	2018	By contrast, cafestol upregulated cyclic-strain-induced HO-1 and Sirt1 expression.	cafestol	13-21	heme oxygenase 1	Homo sapiens	56-60	
29854096-10	2018	This is the first study to report that cafestol inhibited cyclic-strain-induced inflammatory molecule secretion, possibly through the activation of HO-1 and Sirt1 in endothelial cells.	cafestol	39-47	heme oxygenase 1	Homo sapiens	148-152	
29246853-7	2018	Further experiments demonstrated that cafestol increased translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and expression of enhanced heme oxygenase-1.	cafestol	38-46	heme oxygenase 1	Homo sapiens	152-168	
29246853-9	2018	Cafestol"s inhibitory effects on interleukin-8 expression and cellular proliferation induced by urotensin II were significantly abrogated by heme oxygenase-1 silencing, suggesting it may be involved in mediating the effects of cafestol.	cafestol	0-8	heme oxygenase 1	Homo sapiens	141-157	
29246853-9	2018	Cafestol"s inhibitory effects on interleukin-8 expression and cellular proliferation induced by urotensin II were significantly abrogated by heme oxygenase-1 silencing, suggesting it may be involved in mediating the effects of cafestol.	cafestol	227-235	heme oxygenase 1	Homo sapiens	141-157	
29246853-10	2018	This study reports that cafestol inhibits urotensin II-induced interleukin-8 expression and cell proliferation via Nrf2/heme oxygenase-1-dependent mechanism in endothelial cells.	cafestol	24-32	heme oxygenase 1	Homo sapiens	120-136