PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11589708-1 2001 The sialic acid N-glycolylneuraminic acid (Neu5Gc) is synthesized by the action of CMP-Neu5Ac hydroxylase. N-Acetylneuraminic Acid 4-15 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 83-105 12192086-1 2002 Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH). N-Acetylneuraminic Acid 57-68 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 214-237 12192086-1 2002 Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH). N-Acetylneuraminic Acid 57-68 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 239-243 12192086-1 2002 Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH). N-Acetylneuraminic Acid 189-212 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 214-237 12192086-1 2002 Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH). N-Acetylneuraminic Acid 189-212 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 239-243 12880951-1 2003 Rodent cells, widely used for the industrial production of recombinant human glycoproteins, possess CMP-N-acetylneuraminic acid hydroxylase (CMP-Neu5Ac hydroxylase; EC 1.14.13.45) which is the key enzyme in the formation of the sialic acid, N-glycolylneuraminic acid (Neu5Gc). N-Acetylneuraminic Acid 228-239 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 100-139 12880951-1 2003 Rodent cells, widely used for the industrial production of recombinant human glycoproteins, possess CMP-N-acetylneuraminic acid hydroxylase (CMP-Neu5Ac hydroxylase; EC 1.14.13.45) which is the key enzyme in the formation of the sialic acid, N-glycolylneuraminic acid (Neu5Gc). N-Acetylneuraminic Acid 228-239 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 141-163 32664459-1 2020 N-glycolylneuraminic acid (NeuGc), a non-human sialic acid derivative synthesized by cytidine-5"-monophospho-N-acetylneuraminic acid hydroxylase (CMAH), plays a crucial role in mediating infections by certain pathogens. N-Acetylneuraminic Acid 47-58 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 85-144 10052592-1 1998 The biosynthesis of the sialic acid N-glycolylneuraminic acid (Neu5Gc) occurs by the action of cytidine monophosphate-N-acetylneuraminate (CMP-Neu5Ac) hydroxylase. N-Acetylneuraminic Acid 24-35 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 139-162 34294193-1 2021 Humans cannot synthesize the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an inactivating deletion in the cytidine-5"-monophospho-(CMP)-N-acetylneuraminic acid hydroxylase (CMAH) gene responsible for its synthesis. N-Acetylneuraminic Acid 46-57 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 136-201 34294193-1 2021 Humans cannot synthesize the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an inactivating deletion in the cytidine-5"-monophospho-(CMP)-N-acetylneuraminic acid hydroxylase (CMAH) gene responsible for its synthesis. N-Acetylneuraminic Acid 46-57 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 203-207 9343941-2 1997 N-Glycolylneuraminic acid is formed from N-acetylneuraminic acid by the action of the CMP-N-acetylneuraminic acid hydroxylase studied in various animals. N-Acetylneuraminic Acid 41-64 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 86-125 34587757-1 2021 OBJECTIVE: Species-specific pseudogenization of the CMAH gene during human evolution eliminated common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) biosynthesis from its precursor N-acetylneuraminic acid (Neu5Ac). N-Acetylneuraminic Acid 192-215 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 52-56 34587757-1 2021 OBJECTIVE: Species-specific pseudogenization of the CMAH gene during human evolution eliminated common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) biosynthesis from its precursor N-acetylneuraminic acid (Neu5Ac). N-Acetylneuraminic Acid 217-223 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 52-56 32664459-1 2020 N-glycolylneuraminic acid (NeuGc), a non-human sialic acid derivative synthesized by cytidine-5"-monophospho-N-acetylneuraminic acid hydroxylase (CMAH), plays a crucial role in mediating infections by certain pathogens. N-Acetylneuraminic Acid 47-58 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 146-150 31628314-6 2019 This previously unknown glycan-dependent mode of allosteric mechanical activation of a G protein-coupled receptor contributes to meningococcal species selectivity, since Neu5Ac is only abundant in humans due to the loss of CMAH, the enzyme converting Neu5Ac into N-glycolyl-neuraminic acid in other mammals. N-Acetylneuraminic Acid 251-257 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 223-227 32556248-1 2020 Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" (SAMPs) that modulate innate immunity via engagement of CD33-related-Siglec receptors. N-Acetylneuraminic Acid 74-85 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 39-43 32556248-1 2020 Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" (SAMPs) that modulate innate immunity via engagement of CD33-related-Siglec receptors. N-Acetylneuraminic Acid 138-144 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 39-43 31681287-2 2019 Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group addition catalyzed by CMP-Neu5Ac hydroxylase enzyme (CMAH). N-Acetylneuraminic Acid 33-56 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 130-159 31681287-2 2019 Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group addition catalyzed by CMP-Neu5Ac hydroxylase enzyme (CMAH). N-Acetylneuraminic Acid 33-56 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 161-165 31681287-2 2019 Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group addition catalyzed by CMP-Neu5Ac hydroxylase enzyme (CMAH). N-Acetylneuraminic Acid 58-64 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 130-159 31681287-2 2019 Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group addition catalyzed by CMP-Neu5Ac hydroxylase enzyme (CMAH). N-Acetylneuraminic Acid 58-64 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 161-165 31134048-4 2019 In all cases, loss-of-function mutations in the gene encoding the sialic acid-modifying enzyme CMAH are responsible for the drastic change in these species. N-Acetylneuraminic Acid 66-77 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 95-99 31332008-6 2019 Humans exhibit a species-specific deficiency of the sialic acid N-glycolylneuraminic acid (Neu5Gc), due to pseudogenization of cytidine monophosphate-N-acetylneuraminic acid (Neu5Ac) hydroxylase (CMAH), which occurred in hominin ancestors ~2 to 3 Mya. N-Acetylneuraminic Acid 52-63 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 196-200 31289278-4 2019 The use of cell lines for testing GM3(Neu5Gc)-targeting strategies, in particular for human malignancies, is complicated by the absence in humans of functional cytidine monophospho-N-acetyl-neuraminic acid hydroxylase (CMAH), the enzyme required for Neu5Gc sialic acid biosynthesis. N-Acetylneuraminic Acid 257-268 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 160-217 30616506-2 2019 However, mouse and human are different in sialylation patterns of proteins due to evolutionary mutations of the CMP-N-acetylneuraminic acid hydroxylase (CMAH) gene that prevent formation of N-glycolylneuraminic acid from N-acetylneuraminic acid. N-Acetylneuraminic Acid 116-139 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 153-157 30564250-3 2018 A type of sialic acid called N-glycolylneuraminic acid (Neu5Gc) is abundant in many mammalian lineages including great apes, the closest extant relatives of modern human, but was lost in the lineage leading to modern human via the pseudogenization of the CMAH gene encoding the enzyme that converts N-acetylneuraminic acid (Neu5Ac) to Neu5Gc. N-Acetylneuraminic Acid 10-21 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 255-259 28893995-1 2017 Biosynthesis of the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) was lost during human evolution due to inactivation of the CMAH gene, possibly expediting divergence of the Homo lineage, due to a partial fertility barrier. N-Acetylneuraminic Acid 37-48 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 143-147 29206915-1 2018 The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for the synthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surface proteins of most deuterostomes. N-Acetylneuraminic Acid 132-143 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 52-56 28049733-2 2017 The major sialic acids in most mammalian tissues are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), the latter being derived from Neu5Ac via addition of one oxygen atom at the sugar nucleotide level by CMP-Neu5Ac hydroxylase (Cmah). N-Acetylneuraminic Acid 156-162 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 228-250 28423240-1 2017 About 2-3 million years ago, Alu-mediated deletion of a critical exon in the CMAH gene became fixed in the hominin lineage ancestral to humans, possibly through a stepwise process of selection by pathogen targeting of the CMAH product (the sialic acid Neu5Gc), followed by reproductive isolation through female anti-Neu5Gc antibodies. N-Acetylneuraminic Acid 240-251 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 77-81 28423240-1 2017 About 2-3 million years ago, Alu-mediated deletion of a critical exon in the CMAH gene became fixed in the hominin lineage ancestral to humans, possibly through a stepwise process of selection by pathogen targeting of the CMAH product (the sialic acid Neu5Gc), followed by reproductive isolation through female anti-Neu5Gc antibodies. N-Acetylneuraminic Acid 240-251 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 222-226 28049733-2 2017 The major sialic acids in most mammalian tissues are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), the latter being derived from Neu5Ac via addition of one oxygen atom at the sugar nucleotide level by CMP-Neu5Ac hydroxylase (Cmah). N-Acetylneuraminic Acid 156-162 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 252-256 25517696-2 2014 Neu5Gc is synthesized from Neu5Ac by the enzyme cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH). N-Acetylneuraminic Acid 27-33 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 48-106 27041489-3 2016 While macaques synthesize the sialic acid variant N-glycolylneuraminic acid (Neu5Gc), humans cannot because of a mutation in the enzyme CMAH that converts N-acetylneuraminic acid (Neu5Ac) to Neu5Gc. N-Acetylneuraminic Acid 155-178 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 136-140 27041489-3 2016 While macaques synthesize the sialic acid variant N-glycolylneuraminic acid (Neu5Gc), humans cannot because of a mutation in the enzyme CMAH that converts N-acetylneuraminic acid (Neu5Ac) to Neu5Gc. N-Acetylneuraminic Acid 180-186 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 136-140 27567275-5 2016 Anti-Neu5Gc, found only in humans, appeared in hominins <6 mya, following elimination of N-glycolylneuraminic-acid (Neu5Gc) because of inactivation of CMAH, the gene encoding hydroxylase that converts N-acetylneuraminic-acid (Neu5Ac) into Neu5Gc. N-Acetylneuraminic Acid 204-227 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 154-158 27567275-5 2016 Anti-Neu5Gc, found only in humans, appeared in hominins <6 mya, following elimination of N-glycolylneuraminic-acid (Neu5Gc) because of inactivation of CMAH, the gene encoding hydroxylase that converts N-acetylneuraminic-acid (Neu5Ac) into Neu5Gc. N-Acetylneuraminic Acid 229-235 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 154-158 27593514-3 2016 Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac. N-Acetylneuraminic Acid 104-107 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 29-87 27593514-3 2016 Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac. N-Acetylneuraminic Acid 104-107 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 89-93 27593514-3 2016 Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac. N-Acetylneuraminic Acid 52-75 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 89-93 27593514-3 2016 Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac. N-Acetylneuraminic Acid 52-75 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 206-210 27593514-3 2016 Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac. N-Acetylneuraminic Acid 133-139 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 29-87 27593514-3 2016 Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac. N-Acetylneuraminic Acid 133-139 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 89-93 27593514-3 2016 Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac. N-Acetylneuraminic Acid 133-139 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 206-210 27593514-3 2016 Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac. N-Acetylneuraminic Acid 252-258 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 89-93 26235586-8 2015 HPLC analysis showed conversion of CMP-Neu5Ac to CMP-Neu5Gc by the secretory CMAH. N-Acetylneuraminic Acid 39-45 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 77-81 25517696-2 2014 Neu5Gc is synthesized from Neu5Ac by the enzyme cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH). N-Acetylneuraminic Acid 27-33 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 108-112 23709682-2 2013 Humans have a unique mutation of the enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH), causing loss of expression of the sialic acid Neu5Gc. N-Acetylneuraminic Acid 126-137 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 44-83 25480294-4 2014 Human glycans are unusual because of the lack of CMAH, which in other mammals converts N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic acid (Neu5Gc). N-Acetylneuraminic Acid 87-110 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 49-53 25480294-4 2014 Human glycans are unusual because of the lack of CMAH, which in other mammals converts N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic acid (Neu5Gc). N-Acetylneuraminic Acid 112-118 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 49-53 23709682-2 2013 Humans have a unique mutation of the enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH), causing loss of expression of the sialic acid Neu5Gc. N-Acetylneuraminic Acid 126-137 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 85-89 20197272-2 2010 The only known biosynthetic pathway of Neu5Gc is the hydroxylation of cytidine-5"-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac), catalyzed by CMP-Neu5Ac hydroxylase (CMAH). N-Acetylneuraminic Acid 125-131 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 147-169 21350118-4 2011 The CMAH enzyme catalyzes the generation of CMP-Neu5Gc by the transfer of a single oxygen atom to the acyl group of CMP-Neu5Ac. N-Acetylneuraminic Acid 120-126 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 4-8 20668298-1 2010 During the evolution of humans, an inactivating deletion was introduced in the CMAH (cytidine monophosphate-sialic acid hydroxylase) gene, which eliminated biosynthesis of the common mammalian sialic acid N-glycolylneuraminic acid from all human cells. N-Acetylneuraminic Acid 108-119 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 79-83 20197272-2 2010 The only known biosynthetic pathway of Neu5Gc is the hydroxylation of cytidine-5"-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac), catalyzed by CMP-Neu5Ac hydroxylase (CMAH). N-Acetylneuraminic Acid 125-131 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 171-175 20445087-4 2010 Specific events include Alu-mediated inactivation of the CMAH gene, resulting in loss of synthesis of the Sia N-glycolylneuraminic acid (Neu5Gc) and increase in expression of the precursor N-acetylneuraminic acid (Neu5Ac); increased expression of alpha2-6-linked Sias (likely because of changed expression of ST6GALI); and multiple changes in SIGLEC genes encoding Sia-recognizing Ig-like lectins (Siglecs). N-Acetylneuraminic Acid 189-212 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 57-61 20445087-4 2010 Specific events include Alu-mediated inactivation of the CMAH gene, resulting in loss of synthesis of the Sia N-glycolylneuraminic acid (Neu5Gc) and increase in expression of the precursor N-acetylneuraminic acid (Neu5Ac); increased expression of alpha2-6-linked Sias (likely because of changed expression of ST6GALI); and multiple changes in SIGLEC genes encoding Sia-recognizing Ig-like lectins (Siglecs). N-Acetylneuraminic Acid 214-220 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 57-61 17420276-2 2007 One rare difference is a human-specific inactivating deletion in the CMAH gene, which determines biosynthesis of the sialic acid N-glycolylneuraminic acid (Neu5Gc). N-Acetylneuraminic Acid 117-128 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 69-73 19666593-9 2009 First, inactivation of the CMAH gene in the human lineage rendered human ancestors unable to generate the sialic acid Neu5Gc from its precursor Neu5Ac, and likely made humans resistant to P. reichenowi. N-Acetylneuraminic Acid 106-117 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 27-31 19666593-9 2009 First, inactivation of the CMAH gene in the human lineage rendered human ancestors unable to generate the sialic acid Neu5Gc from its precursor Neu5Ac, and likely made humans resistant to P. reichenowi. N-Acetylneuraminic Acid 144-150 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 27-31 18777136-3 2009 An inactivating mutation in the CMAH gene eliminated human expression of N-glycolylneuraminic acid (Neu5Gc) a major sialic acid in "great apes". N-Acetylneuraminic Acid 116-127 cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens 32-36