PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6729777-5 1984 In addition, the effects of citrate on the clotting of purified, calcium-free fibrinogen from cirrhotic patients correlated with the sialic acid content. N-Acetylneuraminic Acid 133-144 fibrinogen beta chain Homo sapiens 78-88 2549051-0 1989 Fibrinogen sialic acid residues are low affinity calcium-binding sites that influence fibrin assembly. N-Acetylneuraminic Acid 11-22 fibrinogen beta chain Homo sapiens 0-10 2549051-4 1989 In this study, we show that removal of fibrinogen sialic acid residues results in loss of low affinity Ca2+-binding sites. N-Acetylneuraminic Acid 50-61 fibrinogen beta chain Homo sapiens 39-49 2549051-7 1989 These observations suggest that the high affinity fibrinogen D-domain Ca2+-binding sites may play a role in the tertiary structure of the D-domain, whereas, sialic acid residues are low affinity sites whose occupancy by Ca2+ at physiological calcium concentration facilitates fibrin polymerization. N-Acetylneuraminic Acid 157-168 fibrinogen beta chain Homo sapiens 50-60 4077019-5 1985 The total content of sialic acid in purified abnormal fibrinogen was markedly increased as compared to that in purified normal fibrinogen. N-Acetylneuraminic Acid 21-32 fibrinogen beta chain Homo sapiens 54-64 4077019-8 1985 It was reported by Harvey (1978) that an abnormal fibrinogen in liver diseases was similar to the fetal fibrinogen in the content of sialic acid and prolongation of thrombin time. N-Acetylneuraminic Acid 133-144 fibrinogen beta chain Homo sapiens 50-60 4077019-8 1985 It was reported by Harvey (1978) that an abnormal fibrinogen in liver diseases was similar to the fetal fibrinogen in the content of sialic acid and prolongation of thrombin time. N-Acetylneuraminic Acid 133-144 fibrinogen beta chain Homo sapiens 104-114 2954261-10 1987 Sialic acid content was markedly decreased in fibrinogen Barcelona. N-Acetylneuraminic Acid 0-11 fibrinogen beta chain Homo sapiens 46-56 3985042-3 1985 This report describes the clinical course of a patient who at the time of diagnosis of nonmetastatic renal cell carcinoma had dysfibrinogenemia characterized by prolongation of the thrombin and Reptilase times and increased sialic acid content of the purified fibrinogen. N-Acetylneuraminic Acid 224-235 fibrinogen beta chain Homo sapiens 129-139 6437459-0 1984 Effects of variant gamma chains and sialic acid content of fibrinogen upon its interactions with ADP-stimulated human and rabbit platelets. N-Acetylneuraminic Acid 36-47 fibrinogen beta chain Homo sapiens 59-69 6437459-3 1984 Normal human fibrinogen, which consists of three pairs of disulfide-bonded peptide chains, (A alpha, B beta, gamma)2, is heterogeneous with respect to sialic acid content and also contains a small proportion of molecules with a variant gamma chain (designated gamma"), elongated by a peptide extension at the COOH-terminus of the normal gamma chain. N-Acetylneuraminic Acid 151-162 fibrinogen beta chain Homo sapiens 13-23 6437459-7 1984 We conclude that the sialic acid content of fibrinogen does not significantly affect its interactions with platelets, but the elongated gamma" chains bind less effectively to ADP-stimulated platelets, and thus reduce the ability of fibrinogen to support aggregation. N-Acetylneuraminic Acid 21-32 fibrinogen beta chain Homo sapiens 44-54 6205441-0 1984 An abnormal fibrinogen (Copenhagen II) with increased sialic acid content associated with thrombotic tendency and normal liver function. N-Acetylneuraminic Acid 54-65 fibrinogen beta chain Homo sapiens 12-22 6205441-1 1984 An increased sialic acid content of the fibrinogen molecule is found in foetal fibrinogen and as an acquired disorder in hepatic disease. N-Acetylneuraminic Acid 13-24 fibrinogen beta chain Homo sapiens 40-50 6205441-1 1984 An increased sialic acid content of the fibrinogen molecule is found in foetal fibrinogen and as an acquired disorder in hepatic disease. N-Acetylneuraminic Acid 13-24 fibrinogen beta chain Homo sapiens 79-89 6205441-3 1984 The purified fibrinogen had a significantly increased content of sialic acid, an abnormal fibrin monomer polymerization, and a changed mobility in crossed affinity-immunoelectrophoresis using immobilized helix pomatia lectin. N-Acetylneuraminic Acid 65-76 fibrinogen beta chain Homo sapiens 13-23 6205441-5 1984 The occurrence of a thrombotic tendency and an increased fibrinogen sialic acid content without signs of liver disease may represent a new variant of congenital dysfibrinogenaemia. N-Acetylneuraminic Acid 68-79 fibrinogen beta chain Homo sapiens 57-67 6729777-6 1984 It is concluded that binding of citrate ions to fibrinogen renders the molecule acutely more sensitive to elevations in the sialic acid content, and that a simple plasma clot opacity test in the presence of excess citrate may be a useful aid in the differential diagnosis of liver disease. N-Acetylneuraminic Acid 124-135 fibrinogen beta chain Homo sapiens 48-58 7147211-2 1982 The removal, with time, of sialic acid residues from human fibrinogen by neuraminidase, can be explained, as a result of a mathematical analysis, by the summation of two first order reactions with clearly different rate constants. N-Acetylneuraminic Acid 27-38 fibrinogen beta chain Homo sapiens 59-69 6575678-0 1983 The plasma fibrinogen fraction with elevated sialic acid content and elongated gamma chains. N-Acetylneuraminic Acid 45-56 fibrinogen beta chain Homo sapiens 11-21 7147211-3 1982 Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains. N-Acetylneuraminic Acid 34-45 fibrinogen beta chain Homo sapiens 58-68 7147211-3 1982 Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains. N-Acetylneuraminic Acid 34-45 fibrinogen beta chain Homo sapiens 138-148 7147211-3 1982 Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains. N-Acetylneuraminic Acid 199-210 fibrinogen beta chain Homo sapiens 58-68 7147211-3 1982 Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains. N-Acetylneuraminic Acid 199-210 fibrinogen beta chain Homo sapiens 138-148 7147211-5 1982 Coagulation with thrombin of desialylated fibrinogen shows that the aggregation rate increases linearly as the amount of sialic acid residues decreases, regardless of their location in the fibrinogen molecule. N-Acetylneuraminic Acid 121-132 fibrinogen beta chain Homo sapiens 42-52 7071802-0 1982 Sialic acid dependent polypeptide chain heterogeneity of human fibrinogen demonstrated by two-dimensional electrophoresis. N-Acetylneuraminic Acid 0-11 fibrinogen beta chain Homo sapiens 63-73 7056710-0 1982 A subfraction of human fibrinogen with high sialic acid content and elongated gamma chains. N-Acetylneuraminic Acid 44-55 fibrinogen beta chain Homo sapiens 23-33 7056710-3 1982 The most acidic fraction comprising 22% of the whole fibrinogen pool was prominent by two special features: 1) its sialic acid content was significantly higher than that of bulk fibrinogen, namely 8 mol of sialic acid/mol of fibrinogen versus 6 mol in bulk fibrinogen. N-Acetylneuraminic Acid 115-126 fibrinogen beta chain Homo sapiens 53-63 7071802-6 1982 It is concluded that enzymatic removal of sialic acid partially reduced the heterogeneity of the gamma- and B beta-polypeptide chains of human fibrinogen, but additional sources producing charge heterogeneity must be sought. N-Acetylneuraminic Acid 42-53 fibrinogen beta chain Homo sapiens 143-153 7129234-1 1982 Fibrinogen-bound sialic acid was determined in a large series of normal adult, full-term pre-term cord blood samples. N-Acetylneuraminic Acid 17-28 fibrinogen beta chain Homo sapiens 0-10 6290353-0 1982 Fibrinogen-bound sialic acid levels in the dysfibrinogenaemia of liver disease. N-Acetylneuraminic Acid 17-28 fibrinogen beta chain Homo sapiens 0-10 6290353-1 1982 Fibrinogen-bound sialic acid levels were determined in 75 normal controls and 80 patients with liver disease. N-Acetylneuraminic Acid 17-28 fibrinogen beta chain Homo sapiens 0-10 7129234-2 1982 Sialic acid was significantly higher in the full-term cord fibrinogen than controls, and higher in premature than term samples. N-Acetylneuraminic Acid 0-11 fibrinogen beta chain Homo sapiens 59-69 7129234-5 1982 It is concluded that fetal fibrinogen is characterised by an elevated sialic acid content, and that the degree of hypersialation is a function of gestational age. N-Acetylneuraminic Acid 70-81 fibrinogen beta chain Homo sapiens 27-37 482913-0 1979 [Importance of the sialic acid moiety for the heterogeneity in human fibrinogen]. N-Acetylneuraminic Acid 19-30 fibrinogen beta chain Homo sapiens 69-79 482913-5 1979 The difference in sialic acid content of the gamma- and B beta-chain variants of human fibrinogen therefore explains on part of the polypeptide chain heterogeneity. N-Acetylneuraminic Acid 18-29 fibrinogen beta chain Homo sapiens 87-97 207986-7 1978 Enzymatic cleavage of sialic acid from the abnormal fibrinogen restored fibrinogen function to normal. N-Acetylneuraminic Acid 22-33 fibrinogen beta chain Homo sapiens 52-62 207986-7 1978 Enzymatic cleavage of sialic acid from the abnormal fibrinogen restored fibrinogen function to normal. N-Acetylneuraminic Acid 22-33 fibrinogen beta chain Homo sapiens 72-82 13928162-0 1963 Sialic acid in fibrinogen and "vulcanization" of the fibrin clot. N-Acetylneuraminic Acid 0-11 fibrinogen beta chain Homo sapiens 15-25 833473-1 1977 The role of sialic acid in the functional and metabolic properties of purified human fibrinogen was investigated. N-Acetylneuraminic Acid 12-23 fibrinogen beta chain Homo sapiens 85-95 833473-2 1977 Fibrinogen treated with Vibrio cholerae neuraminidase released 90 percent of its sialic acid without evidence of proteolysis, as indicated by the presence of intace A alpha, B beta, and gamma chains on sodium dodecylsulfate (SDS)-polyacrylamide gels of the reduced asialoprotein. N-Acetylneuraminic Acid 81-92 fibrinogen beta chain Homo sapiens 0-10 624734-0 1978 Separation of both the Bbeta- and the gamma-polypeptide chains of human fibrinogen into two main types which differ in sialic acid content. N-Acetylneuraminic Acid 119-130 fibrinogen beta chain Homo sapiens 72-82 624734-8 1978 A larger ratio of L/R in the gamma and Bbeta chains of dysfibrinogenemia fibrinogen "Zurich II" than in those of normal fibrinogen explains the higher content of sialic acid measured in the native Zurich II fibrinogen molecule. N-Acetylneuraminic Acid 162-173 fibrinogen beta chain Homo sapiens 58-68 624734-8 1978 A larger ratio of L/R in the gamma and Bbeta chains of dysfibrinogenemia fibrinogen "Zurich II" than in those of normal fibrinogen explains the higher content of sialic acid measured in the native Zurich II fibrinogen molecule. N-Acetylneuraminic Acid 162-173 fibrinogen beta chain Homo sapiens 73-83 624734-8 1978 A larger ratio of L/R in the gamma and Bbeta chains of dysfibrinogenemia fibrinogen "Zurich II" than in those of normal fibrinogen explains the higher content of sialic acid measured in the native Zurich II fibrinogen molecule. N-Acetylneuraminic Acid 162-173 fibrinogen beta chain Homo sapiens 73-83 4974308-20 1969 Total carbohydrates, protein-bound hexoses, sialic acid, and hexosamine were decreased in the abnormal fibrinogen. N-Acetylneuraminic Acid 44-55 fibrinogen beta chain Homo sapiens 103-113 26050259-5 2015 Fibrin, which is proteolytically produced from fibrinogen by thrombin, binds to the same sugar residues as fibrinogen in the presence of 5 mM Ca(2+), while it markedly binds to N-acetylneuraminic acid in the absence of Ca(2+). N-Acetylneuraminic Acid 177-200 fibrinogen beta chain Homo sapiens 47-57 12598072-10 2003 The addition of sialic acid, which inhibits RBC-RBC aggregation, decreased the amount of SEC, even in the presence of Fg. N-Acetylneuraminic Acid 16-27 fibrinogen beta chain Homo sapiens 118-120 18083324-7 2008 These results suggest that fibrinogen and fibronectin facilitate the adherence of conidia to A549 cells probably through the interaction with adhesin-type molecules or a sialic acid based recognition system. N-Acetylneuraminic Acid 170-181 fibrinogen beta chain Homo sapiens 27-37 26118196-6 2015 RESULTS: There were significant correlations between SA and fibrinogen, D-dimer, factor (F) IX, and platelet (PLT) that were independent of smoking, body mass index (BMI), waist-to-hip ratio, hemoglobin A(1c) (HbA1c), fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TC) to high-density lipoprotein cholesterol (HDL-C) ratio, and antithrombotic therapy history. N-Acetylneuraminic Acid 53-55 fibrinogen beta chain Homo sapiens 60-70 23315163-5 2013 Sialidase treatment of fibrinogen reversed the suppressive effect of siglec-E on CD11b signaling, suggesting that sialic acid recognition by siglec-E is required for its inhibitory function. N-Acetylneuraminic Acid 114-125 fibrinogen beta chain Homo sapiens 23-33 21192254-1 2011 Fibrinogen has previously been demonstrated to exist in a "fetal" form, in cord blood of term infants, with increased sialic acid content compared to adult fibrinogen. N-Acetylneuraminic Acid 118-129 fibrinogen beta chain Homo sapiens 0-10 11755951-11 2001 A positive correlation was found between fibrinogen and SA levels (r=.5, P<.01). N-Acetylneuraminic Acid 56-58 fibrinogen beta chain Homo sapiens 41-51 12441907-2 2002 To elucidate the mechanism of the relation of serum sialic acid to fibrinogen, the relationship between serum sialic acid and markers of blood coagulation activity was investigated in type 2 diabetic patients. N-Acetylneuraminic Acid 52-63 fibrinogen beta chain Homo sapiens 67-77 12441907-3 2002 The concentration of serum sialic acid showed significant positive correlations with blood platelet count and with plasma concentrations of fibrinogen, D-dimer, thrombin-antithrombin III complex and plasmin-alpha2 plasmin inhibitor complex. N-Acetylneuraminic Acid 27-38 fibrinogen beta chain Homo sapiens 140-150 12441907-5 2002 The correlation coefficient of blood fibrinogen with serum sialic acid was still significant after adjustment for D-dimer, thrombin-antithrombin III complex or plasmin-alpha2 plasmin inhibitor complex. N-Acetylneuraminic Acid 59-70 fibrinogen beta chain Homo sapiens 37-47 12441907-7 2002 These results suggest that the serum sialic acid level reflects blood coagulation activity in type 2 diabetic patients and is related to blood fibrinogen level independently of blood coagulation activity. N-Acetylneuraminic Acid 37-48 fibrinogen beta chain Homo sapiens 143-153 9716150-4 1998 Mass measurements of intact Kaiserslautern gamma chains after neuraminidase treatment of the native fibrinogen confirmed a total of three residues of sialic acid in the dominant isoform. N-Acetylneuraminic Acid 150-161 fibrinogen beta chain Homo sapiens 100-110 9716150-7 1998 It appears that the polymerisation defect of this fibrinogen results from electrostatic repulsion between condensing protofibrils and that this is induced by the two new residues of sialic acid that are present on the new gamma chain. N-Acetylneuraminic Acid 182-193 fibrinogen beta chain Homo sapiens 50-60 8972015-5 1996 We conclude that decreased erythrocyte sialic acid content may intensify the effect of fibrinogen on aggregation and disaggregation of erythrocytes and participate in the development of atherothrombotic complications. N-Acetylneuraminic Acid 39-50 fibrinogen beta chain Homo sapiens 87-97 8899146-0 1996 Plasma fibrinogen and its relationship to plasma sialic acid in non-insulin-dependent diabetes mellitus. N-Acetylneuraminic Acid 49-60 fibrinogen beta chain Homo sapiens 7-17 8899146-2 1996 We postulated that plasma SA may be related to plasma fibrinogen, another reputed cardiovascular risk factor. N-Acetylneuraminic Acid 26-28 fibrinogen beta chain Homo sapiens 54-64 8899146-6 1996 There was a strong univariate correlation between plasma fibrinogen and plasma SA in both NIDDM patients (r = 0.80, P < 0.001) and control subjects (r = 0.54, P < 0.01). N-Acetylneuraminic Acid 79-81 fibrinogen beta chain Homo sapiens 57-67 7749766-6 1995 Fibrinogen was purified via glycine precipitation, and the sialic acid (SA) content was determined. N-Acetylneuraminic Acid 59-70 fibrinogen beta chain Homo sapiens 0-10 7749766-6 1995 Fibrinogen was purified via glycine precipitation, and the sialic acid (SA) content was determined. N-Acetylneuraminic Acid 72-74 fibrinogen beta chain Homo sapiens 0-10 7749766-12 1995 CONCLUSIONS: These data support the notion that an altered fibrinogen exists in some children with nephrotic syndrome characterized by an increased TT and RT, elevated fibrinogen, and both an increased negative charge and SA content. N-Acetylneuraminic Acid 222-224 fibrinogen beta chain Homo sapiens 59-69 7742784-0 1995 The effects of pH on the generation of turbidity and elasticity associated with fibrinogen-fibrin conversion by thrombin are remarkably influenced by sialic acid in fibrinogen. N-Acetylneuraminic Acid 150-161 fibrinogen beta chain Homo sapiens 80-90 7742784-0 1995 The effects of pH on the generation of turbidity and elasticity associated with fibrinogen-fibrin conversion by thrombin are remarkably influenced by sialic acid in fibrinogen. N-Acetylneuraminic Acid 150-161 fibrinogen beta chain Homo sapiens 165-175 7742784-6 1995 Concerning the elasticity evaluated by thromboelastography, the coagulation time (k) and the maximum amplitude (ma) were lower in asialofibrinogen, indicating a deterioration of the clotting function of fibrinogen with the loss of sialic acid. N-Acetylneuraminic Acid 231-242 fibrinogen beta chain Homo sapiens 136-146 7742784-7 1995 These results suggest that sialic acid bound to fibrinogen is closely related to the fibrin network formation in blood coagulation, which is the most important function of fibrinogen, and plays a functional role in the stabilization of fibrin clot formation against environmental changes, including pH. N-Acetylneuraminic Acid 27-38 fibrinogen beta chain Homo sapiens 48-58 7742784-7 1995 These results suggest that sialic acid bound to fibrinogen is closely related to the fibrin network formation in blood coagulation, which is the most important function of fibrinogen, and plays a functional role in the stabilization of fibrin clot formation against environmental changes, including pH. N-Acetylneuraminic Acid 27-38 fibrinogen beta chain Homo sapiens 172-182 15374461-0 1991 Age dependency of the sialic acid content of fibrinogen. N-Acetylneuraminic Acid 22-33 fibrinogen beta chain Homo sapiens 45-55 15374461-4 1991 The higher plasma SA is caused by increasing concentrations of glycoproteins like fibrinogen, but also by a higher content of SA/mg protein, as has been shown for fibrinogen. N-Acetylneuraminic Acid 18-20 fibrinogen beta chain Homo sapiens 82-92 15374461-4 1991 The higher plasma SA is caused by increasing concentrations of glycoproteins like fibrinogen, but also by a higher content of SA/mg protein, as has been shown for fibrinogen. N-Acetylneuraminic Acid 18-20 fibrinogen beta chain Homo sapiens 163-173 15374461-7 1991 An increased red cell aggregation with fibrinogen of healthy elderly correlated with its SA content, but SA is most probably only indicating an altered protein heterogeneity in the aged and not a causative factor that influences erythrocyte aggregation. N-Acetylneuraminic Acid 89-91 fibrinogen beta chain Homo sapiens 39-49 7738493-9 1995 Serum sialic acid correlated strongly with plasma fibrinogen (r = 0.78; P < 0.0001) and erythrocyte sedimentation rate (r = 0.62; P < 0.0001). N-Acetylneuraminic Acid 6-17 fibrinogen beta chain Homo sapiens 50-60 1829631-8 1991 In addition, the patients" fibrinogen showed normal polymerization of preformed fibrin monomers, normal sialic acid content, and normal binding to ADP or epinephrine-stimulated platelets. N-Acetylneuraminic Acid 104-115 fibrinogen beta chain Homo sapiens 27-37 34555851-0 2021 Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics. N-Acetylneuraminic Acid 13-24 fibrinogen beta chain Homo sapiens 55-65 34555851-1 2021 Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen, characterized by increased sialic acid, a greater negative charge, and decreased activity compared to adults. N-Acetylneuraminic Acid 106-117 fibrinogen beta chain Homo sapiens 40-50 34555851-1 2021 Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen, characterized by increased sialic acid, a greater negative charge, and decreased activity compared to adults. N-Acetylneuraminic Acid 106-117 fibrinogen beta chain Homo sapiens 67-77 34555851-5 2021 We hypothesized that the increased sialic acid content of neonatal fibrinogen promotes fibrin B:b knob hole interactions and consequently influences the structure and function of the neonatal fibrin matrix. N-Acetylneuraminic Acid 35-46 fibrinogen beta chain Homo sapiens 67-77 34555851-8 2021 We determined that sialic acid content of neonatal fibrinogen is a key determinant of resulting clot properties. N-Acetylneuraminic Acid 19-30 fibrinogen beta chain Homo sapiens 51-61