PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33994786-2	2020	In addition, mEH metabolizes polycyclic aromatic hydrocarbons, one of the causative factors of atherosclerotic lesion development.	Polycyclic Aromatic Hydrocarbons	29-61	epoxide hydrolase 1, microsomal	Mus musculus	13-16	
23564882-1	2013	Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	247-279	epoxide hydrolase 1, microsomal	Mus musculus	30-33	
22096847-11	2011	CONCLUSION: The results of present study suggested that PAHs exposure could induce the shorted RTL, CYP1A1, mEH, AHR polymorphisms might influence the change of telomere length of genomic DNA in peripheral blood of workers exposed to PAHs.	Polycyclic Aromatic Hydrocarbons	56-60	epoxide hydrolase 1, microsomal	Mus musculus	108-111	
17548691-5	2007	After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05).	Polycyclic Aromatic Hydrocarbons	117-120	epoxide hydrolase 1, microsomal	Mus musculus	174-177	
17082176-1	2007	NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis.	Polycyclic Aromatic Hydrocarbons	222-254	epoxide hydrolase 1, microsomal	Mus musculus	86-89	
17082176-1	2007	NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis.	Polycyclic Aromatic Hydrocarbons	256-260	epoxide hydrolase 1, microsomal	Mus musculus	86-89	
15924351-1	2005	Microsomal epoxide hydrolase (mEH) and cytochrome P450 2C9 (CYP2C9) are involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons (PAHs) derived from tobacco smoke.	Polycyclic Aromatic Hydrocarbons	124-156	epoxide hydrolase 1, microsomal	Mus musculus	30-33	
15924351-1	2005	Microsomal epoxide hydrolase (mEH) and cytochrome P450 2C9 (CYP2C9) are involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons (PAHs) derived from tobacco smoke.	Polycyclic Aromatic Hydrocarbons	158-162	epoxide hydrolase 1, microsomal	Mus musculus	30-33	
15466980-7	2004	Gene-environment interactions between occupational PAH exposure and polymorphisms of mEH and/or GSTM1 were also evident.	Polycyclic Aromatic Hydrocarbons	51-54	epoxide hydrolase 1, microsomal	Mus musculus	85-88	
15466980-8	2004	These results indicate that the mEH, GSTP1, and GSTM1 polymorphisms may play a role in sensitivity or genetic susceptibility to the genotoxic effects of PAH exposure in the coke-oven workers.	Polycyclic Aromatic Hydrocarbons	153-156	epoxide hydrolase 1, microsomal	Mus musculus	32-35	
15355699-8	2004	CONCLUSION: Genetic polymorphism of mEH gene could be a susceptible biomarker in coke oven workers which was involved in the individual susceptibility on metabolism of PAHs.	Polycyclic Aromatic Hydrocarbons	168-172	epoxide hydrolase 1, microsomal	Mus musculus	36-39	
14988221-1	2004	Microsomal epoxide hydrolase (mEH) is involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons derived from tobacco smoke and charred meat intake.	Polycyclic Aromatic Hydrocarbons	90-122	epoxide hydrolase 1, microsomal	Mus musculus	30-33	
15061915-12	2004	CONCLUSION: Significant associations between genetic polymorphisms in GSTM1, NQO1 and mEH gene and risk for chromosomal damage were found among occupational PAH-exposed workers, which related to the mechanism of PAH carcinogenesis.	Polycyclic Aromatic Hydrocarbons	157-160	epoxide hydrolase 1, microsomal	Mus musculus	86-89	
15061915-12	2004	CONCLUSION: Significant associations between genetic polymorphisms in GSTM1, NQO1 and mEH gene and risk for chromosomal damage were found among occupational PAH-exposed workers, which related to the mechanism of PAH carcinogenesis.	Polycyclic Aromatic Hydrocarbons	212-215	epoxide hydrolase 1, microsomal	Mus musculus	86-89	
12935919-1	2003	Microsomal epoxide hydrolase (mEH) gene is polymorphic and its enzyme is involved in the activation and subsequent detoxification of several tobacco carcinogens, for example polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	174-206	epoxide hydrolase 1, microsomal	Mus musculus	30-33	
11489754-1	2001	Microsomal epoxide hydrolase (mEH) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke and cooked meat.	Polycyclic Aromatic Hydrocarbons	47-79	epoxide hydrolase 1, microsomal	Mus musculus	30-33	
9224217-2	1997	PAH are converted to carcinogenic molecules through a combination of monoxygenation by cytochrome p450 (CYP) enzymes in the presence of NADPH oxidoreductase (OR) and hydrolysis by microsomal epoxide hydrolase (mEH).	Polycyclic Aromatic Hydrocarbons	0-3	epoxide hydrolase 1, microsomal	Mus musculus	210-213	
8870659-1	1996	Diol epoxides formed by the sequential action of cytochrome P-450 and the microsomal epoxide hydrolase (mEH) in the endoplasmic reticulum (ER) represent an important class of ultimate carcinogenic metabolites of polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	212-244	epoxide hydrolase 1, microsomal	Mus musculus	104-107	
7788860-2	1995	It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other biotransformation enzymes are important modulators of the bioactivation and detoxification of many environmental chemicals, including constituents of tobacco smoke such as certain nitrosamines and polycyclic aromatic hydrocarbons (PAH).	Polycyclic Aromatic Hydrocarbons	298-330	epoxide hydrolase 1, microsomal	Mus musculus	85-88	
7788860-2	1995	It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other biotransformation enzymes are important modulators of the bioactivation and detoxification of many environmental chemicals, including constituents of tobacco smoke such as certain nitrosamines and polycyclic aromatic hydrocarbons (PAH).	Polycyclic Aromatic Hydrocarbons	332-335	epoxide hydrolase 1, microsomal	Mus musculus	85-88