PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32112355-1 2020 Polycyclic aromatic hydrocarbons (PAHs)/aryl hydrocarbon receptor (AhR) regulate the expression of target genes, including drug transporter genes which harbor xenobiotic response element (XRE) in their promoter regions. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Rattus norvegicus 67-70 32112355-1 2020 Polycyclic aromatic hydrocarbons (PAHs)/aryl hydrocarbon receptor (AhR) regulate the expression of target genes, including drug transporter genes which harbor xenobiotic response element (XRE) in their promoter regions. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Rattus norvegicus 67-70 28285017-3 2017 PAH induced AHR activation may also lead to adverse effects by modulating other pathways, for example estrogen receptor (ER) signaling in the female reproductive tract. Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Rattus norvegicus 12-15 29471110-0 2018 Antagonistic and synergistic interactions during the binding of binary mixtures of polycyclic aromatic hydrocarbons to the aryl hydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 83-115 aryl hydrocarbon receptor Rattus norvegicus 123-148 29471110-5 2018 The binding of B(a)P to the aryl hydrocarbon (Ah) receptor was similarly modulated by other PAHs. Polycyclic Aromatic Hydrocarbons 92-96 aryl hydrocarbon receptor Rattus norvegicus 28-58 29471110-6 2018 No correlation was evident between binding avidity of the PAH to the Ah receptor and either its potential for interaction or nature of interaction, e.g. synergism or antagonism. Polycyclic Aromatic Hydrocarbons 58-61 aryl hydrocarbon receptor Rattus norvegicus 69-80 29471110-8 2018 Bearing in mind the role of the Ah receptor in chemical carcinogenesis, it may be concluded that interactions at the Ah receptor site may contribute to the well-established modulation of the carcinogenicity of one PAH in the presence of another. Polycyclic Aromatic Hydrocarbons 214-217 aryl hydrocarbon receptor Rattus norvegicus 32-43 29471110-8 2018 Bearing in mind the role of the Ah receptor in chemical carcinogenesis, it may be concluded that interactions at the Ah receptor site may contribute to the well-established modulation of the carcinogenicity of one PAH in the presence of another. Polycyclic Aromatic Hydrocarbons 214-217 aryl hydrocarbon receptor Rattus norvegicus 117-128 31368503-0 2019 Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Rattus norvegicus 158-183 31368503-5 2019 Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Polycyclic Aromatic Hydrocarbons 6-10 aryl hydrocarbon receptor Rattus norvegicus 85-110 31368503-5 2019 Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Polycyclic Aromatic Hydrocarbons 6-10 aryl hydrocarbon receptor Rattus norvegicus 112-115 25268939-7 2015 Independently of GJIC modulation, or p38 activation, TNF-alpha potentiated the AhR-dependent proliferative effect of a model low-molecular-weight PAH, fluoranthene, on contact-inhibited cells. Polycyclic Aromatic Hydrocarbons 146-149 aryl hydrocarbon receptor Rattus norvegicus 79-82 25582180-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) develop various adverse effects through activation of an aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Rattus norvegicus 142-167 25582180-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) develop various adverse effects through activation of an aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Rattus norvegicus 169-172 25582180-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) develop various adverse effects through activation of an aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Rattus norvegicus 142-167 25582180-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) develop various adverse effects through activation of an aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Rattus norvegicus 169-172 28104439-1 2017 The objectives of the present study were two-fold: (a) to evaluate the role of molecular shape on the interaction of polycyclic aromatic hydrocarbons (PAHs) with the Ah receptor and CYP1A1 upregulation, and (b) to evaluate the potential of PAHs to induce epoxide hydrolase and glutathione S-transferase, two major enzymes involved in their metabolism. Polycyclic Aromatic Hydrocarbons 117-149 aryl hydrocarbon receptor Rattus norvegicus 166-177 28104439-1 2017 The objectives of the present study were two-fold: (a) to evaluate the role of molecular shape on the interaction of polycyclic aromatic hydrocarbons (PAHs) with the Ah receptor and CYP1A1 upregulation, and (b) to evaluate the potential of PAHs to induce epoxide hydrolase and glutathione S-transferase, two major enzymes involved in their metabolism. Polycyclic Aromatic Hydrocarbons 151-155 aryl hydrocarbon receptor Rattus norvegicus 166-177 24213842-9 2014 The known AhR agonists polycyclic aromatic hydrocarbon, polychlorinated biphenyl, and PCDD/F only explained up to 8 % of the more persistent AhR agonist activity in the samples, which suggests that unidentified AhR-active compounds represented a great proportion of the TCDD EQ in sediments from TGR. Polycyclic Aromatic Hydrocarbons 23-54 aryl hydrocarbon receptor Rattus norvegicus 10-13 24548649-4 2014 The known aryl hydrocarbon receptor (AhR) agonists PAHs and PCBs were analyzed by HRGC/HRMS instrument. Polycyclic Aromatic Hydrocarbons 51-55 aryl hydrocarbon receptor Rattus norvegicus 10-35 24548649-4 2014 The known aryl hydrocarbon receptor (AhR) agonists PAHs and PCBs were analyzed by HRGC/HRMS instrument. Polycyclic Aromatic Hydrocarbons 51-55 aryl hydrocarbon receptor Rattus norvegicus 37-40 24213842-9 2014 The known AhR agonists polycyclic aromatic hydrocarbon, polychlorinated biphenyl, and PCDD/F only explained up to 8 % of the more persistent AhR agonist activity in the samples, which suggests that unidentified AhR-active compounds represented a great proportion of the TCDD EQ in sediments from TGR. Polycyclic Aromatic Hydrocarbons 23-54 aryl hydrocarbon receptor Rattus norvegicus 141-144 24213842-9 2014 The known AhR agonists polycyclic aromatic hydrocarbon, polychlorinated biphenyl, and PCDD/F only explained up to 8 % of the more persistent AhR agonist activity in the samples, which suggests that unidentified AhR-active compounds represented a great proportion of the TCDD EQ in sediments from TGR. Polycyclic Aromatic Hydrocarbons 23-54 aryl hydrocarbon receptor Rattus norvegicus 141-144 20881032-1 2011 The aryl hydrocarbon receptor (AHR) is activated by 3-methylcholanthrene (MC), a polycyclic aromatic hydrocarbon, and environmental contaminants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Polycyclic Aromatic Hydrocarbons 81-112 aryl hydrocarbon receptor Rattus norvegicus 4-29 23887904-2 2013 DEP contain a high level of polycyclic aromatic hydrocarbons, which activate the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 28-60 aryl hydrocarbon receptor Rattus norvegicus 81-106 23887904-2 2013 DEP contain a high level of polycyclic aromatic hydrocarbons, which activate the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 28-60 aryl hydrocarbon receptor Rattus norvegicus 108-111 23502512-4 2013 PAHs in PM can serve as ligands for the aryl hydrocarbon receptor (AhR) that induces expression of certain isozymes in the cytochrome P-450 superfamily, such as CYP1A1 and CYP1B1, localized in specific lung cell types. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Rattus norvegicus 40-65 23502512-4 2013 PAHs in PM can serve as ligands for the aryl hydrocarbon receptor (AhR) that induces expression of certain isozymes in the cytochrome P-450 superfamily, such as CYP1A1 and CYP1B1, localized in specific lung cell types. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Rattus norvegicus 67-70 21604763-3 2011 Transcription factor AhR plays a key role in the metabolic activation of PAHs to genotoxic metabolites, but the AhR activation may also contribute to the tumor promoting effects of PAHs. Polycyclic Aromatic Hydrocarbons 73-77 aryl hydrocarbon receptor Rattus norvegicus 21-24 21604763-3 2011 Transcription factor AhR plays a key role in the metabolic activation of PAHs to genotoxic metabolites, but the AhR activation may also contribute to the tumor promoting effects of PAHs. Polycyclic Aromatic Hydrocarbons 181-185 aryl hydrocarbon receptor Rattus norvegicus 21-24 21604763-3 2011 Transcription factor AhR plays a key role in the metabolic activation of PAHs to genotoxic metabolites, but the AhR activation may also contribute to the tumor promoting effects of PAHs. Polycyclic Aromatic Hydrocarbons 181-185 aryl hydrocarbon receptor Rattus norvegicus 112-115 21762708-0 2011 Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 166-198 aryl hydrocarbon receptor Rattus norvegicus 18-43 21762708-9 2011 The AhR-mediated activity of the neutral fraction was linked to PAHs and their derivatives, as polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls were only minor contributors to the overall AhR-mediated activity. Polycyclic Aromatic Hydrocarbons 64-68 aryl hydrocarbon receptor Rattus norvegicus 4-7 20881032-1 2011 The aryl hydrocarbon receptor (AHR) is activated by 3-methylcholanthrene (MC), a polycyclic aromatic hydrocarbon, and environmental contaminants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Polycyclic Aromatic Hydrocarbons 81-112 aryl hydrocarbon receptor Rattus norvegicus 31-34 19650907-7 2009 Because CYP1A1 is induced via ligand-mediated nuclear translocation of the aryl hydrocarbon receptor (AhR), we investigated the effect of CD on PAH-induced nuclear translocation of AhR in AT-II cells isolated from in vivo-exposed rats. Polycyclic Aromatic Hydrocarbons 144-147 aryl hydrocarbon receptor Rattus norvegicus 181-184 19497421-0 2009 The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells. Polycyclic Aromatic Hydrocarbons 99-131 aryl hydrocarbon receptor Rattus norvegicus 12-37 19497421-12 2009 Taken together, both CYP1 and AKR1C9 appear to be AhR-regulated metabolic pathways, which may contribute to formation of pro-carcinogenic PAH metabolites in liver progenitor cells. Polycyclic Aromatic Hydrocarbons 138-141 aryl hydrocarbon receptor Rattus norvegicus 50-53 19650907-12 2009 CONCLUSION: Our findings suggest that during particle and PAH mixed exposures, CD alters the BNF-induced nuclear translocation of AhR in AT-II cells. Polycyclic Aromatic Hydrocarbons 58-61 aryl hydrocarbon receptor Rattus norvegicus 130-133 19650907-14 2009 Thus, this study suggests that mechanisms for reduced PAH-induced CYP1A1 activity in the CD exposed lung include not only the effects of inflammation on the lung as a whole, but also reduced PAH-associated nuclear translocation of AhR in an expanded population of AT-II cells. Polycyclic Aromatic Hydrocarbons 54-57 aryl hydrocarbon receptor Rattus norvegicus 231-234 19650907-14 2009 Thus, this study suggests that mechanisms for reduced PAH-induced CYP1A1 activity in the CD exposed lung include not only the effects of inflammation on the lung as a whole, but also reduced PAH-associated nuclear translocation of AhR in an expanded population of AT-II cells. Polycyclic Aromatic Hydrocarbons 191-194 aryl hydrocarbon receptor Rattus norvegicus 231-234 18757099-9 2009 Based on the mass balance analysis, PCDD/Fs, PCBs and PAHs could account for the observed AhR responses in vitro elicited by soil extracts, though their respective contributions varied depending on sample location. Polycyclic Aromatic Hydrocarbons 54-58 aryl hydrocarbon receptor Rattus norvegicus 90-93 18634860-2 2008 Many PAHs are aryl hydrocarbon receptor (AhR) ligands and several recent studies have suggested that PAHs or their metabolites may activate estrogen receptors (ER). Polycyclic Aromatic Hydrocarbons 5-9 aryl hydrocarbon receptor Rattus norvegicus 14-39 18634860-2 2008 Many PAHs are aryl hydrocarbon receptor (AhR) ligands and several recent studies have suggested that PAHs or their metabolites may activate estrogen receptors (ER). Polycyclic Aromatic Hydrocarbons 5-9 aryl hydrocarbon receptor Rattus norvegicus 41-44 17941746-8 2007 Contribution of MeAnt and MePhe to overall AhR-inducing potencies should be taken into account in PAH-contaminated environments. Polycyclic Aromatic Hydrocarbons 98-101 aryl hydrocarbon receptor Rattus norvegicus 43-46 17941746-12 2007 In summary, inhibition of GJIC and partial activation of AhR seem to be the most prominent toxic effects of the methylated PAHs in the present study. Polycyclic Aromatic Hydrocarbons 123-127 aryl hydrocarbon receptor Rattus norvegicus 57-60 18039810-4 2008 PAH increased gene expression 23-fold, but the presence of dexamethasone only induced PAH-dependent expression by 1.5-fold, suggesting interaction between GR and the aryl hydrocarbon (Ah) receptor. Polycyclic Aromatic Hydrocarbons 86-89 aryl hydrocarbon receptor Rattus norvegicus 166-196 17431010-1 2007 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxic effects of halogenated aromatic hydrocarbons (HAHs), polycyclic aromatic hydrocarbons (PAHs), and other structurally diverse ligands. Polycyclic Aromatic Hydrocarbons 179-211 aryl hydrocarbon receptor Rattus norvegicus 4-29 17431010-1 2007 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxic effects of halogenated aromatic hydrocarbons (HAHs), polycyclic aromatic hydrocarbons (PAHs), and other structurally diverse ligands. Polycyclic Aromatic Hydrocarbons 179-211 aryl hydrocarbon receptor Rattus norvegicus 31-34 17431010-1 2007 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxic effects of halogenated aromatic hydrocarbons (HAHs), polycyclic aromatic hydrocarbons (PAHs), and other structurally diverse ligands. Polycyclic Aromatic Hydrocarbons 213-217 aryl hydrocarbon receptor Rattus norvegicus 4-29 17431010-1 2007 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxic effects of halogenated aromatic hydrocarbons (HAHs), polycyclic aromatic hydrocarbons (PAHs), and other structurally diverse ligands. Polycyclic Aromatic Hydrocarbons 213-217 aryl hydrocarbon receptor Rattus norvegicus 31-34 12698233-3 2003 Between these treatments, PAH-metabolizing activities encoded by aryl hydrocarbon (Ah) receptor-controlled genes were induced in the rats with beta-naphthoflavone (betaNF). Polycyclic Aromatic Hydrocarbons 26-29 aryl hydrocarbon receptor Rattus norvegicus 65-95 17141280-0 2007 The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells. Polycyclic Aromatic Hydrocarbons 86-118 aryl hydrocarbon receptor Rattus norvegicus 4-29 17141280-11 2007 Transfection of WB-F344 cells with siRNA targeted against AhR decreased induction of Cyclin A induced by BbF or BaP, further supporting the role of AhR in proliferative effects of PAHs. Polycyclic Aromatic Hydrocarbons 180-184 aryl hydrocarbon receptor Rattus norvegicus 58-61 17141280-11 2007 Transfection of WB-F344 cells with siRNA targeted against AhR decreased induction of Cyclin A induced by BbF or BaP, further supporting the role of AhR in proliferative effects of PAHs. Polycyclic Aromatic Hydrocarbons 180-184 aryl hydrocarbon receptor Rattus norvegicus 148-151 16945501-1 2006 During the conduct of a study designed to determine the effect of 3-methylcholanthrene (3-MC), a synthetic polycyclic aromatic hydrocarbon (PAH) that acts through the aryl hydrocarbon receptor (AhR), on uterine contractility in Wistar rats, uterine tumors were identified in both vehicle and 3-MC-treated animals. Polycyclic Aromatic Hydrocarbons 107-138 aryl hydrocarbon receptor Rattus norvegicus 194-197 16945501-1 2006 During the conduct of a study designed to determine the effect of 3-methylcholanthrene (3-MC), a synthetic polycyclic aromatic hydrocarbon (PAH) that acts through the aryl hydrocarbon receptor (AhR), on uterine contractility in Wistar rats, uterine tumors were identified in both vehicle and 3-MC-treated animals. Polycyclic Aromatic Hydrocarbons 140-143 aryl hydrocarbon receptor Rattus norvegicus 167-192 16945501-1 2006 During the conduct of a study designed to determine the effect of 3-methylcholanthrene (3-MC), a synthetic polycyclic aromatic hydrocarbon (PAH) that acts through the aryl hydrocarbon receptor (AhR), on uterine contractility in Wistar rats, uterine tumors were identified in both vehicle and 3-MC-treated animals. Polycyclic Aromatic Hydrocarbons 140-143 aryl hydrocarbon receptor Rattus norvegicus 194-197 16839212-1 2006 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with which halogenated and polycyclic aromatic hydrocarbons such as dioxins and benzo[a]pyrene interact as ligands. Polycyclic Aromatic Hydrocarbons 106-138 aryl hydrocarbon receptor Rattus norvegicus 4-29 16839212-1 2006 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with which halogenated and polycyclic aromatic hydrocarbons such as dioxins and benzo[a]pyrene interact as ligands. Polycyclic Aromatic Hydrocarbons 106-138 aryl hydrocarbon receptor Rattus norvegicus 31-34 16568750-10 2006 Underthis circumstance, a quantitative dose--effect relationship between TEQ(PAH) and EROD activity could be established, suggesting that the observed AhR effect was mostly derived from PAHs. Polycyclic Aromatic Hydrocarbons 77-80 aryl hydrocarbon receptor Rattus norvegicus 151-154 2372874-1 1990 The polycyclic aromatic hydrocarbon (PAH)-induced expression of the rat Cyp1A1 gene is a complex process which appears to be regulated by several trans-acting factors including the 8S (Ah receptor) and 4S PAH binding proteins. Polycyclic Aromatic Hydrocarbons 4-35 aryl hydrocarbon receptor Rattus norvegicus 185-196 12559965-10 2003 Regulation of adhesion proteins through the AHR pathway may represent a novel mechanism of action by atherogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 113-145 aryl hydrocarbon receptor Rattus norvegicus 44-47 10728779-1 2000 The aromatic hydrocarbon receptor (AHR) and AHR nuclear translocator protein (ARNT) mediate the toxic effects of a wide variety of halogenated and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 aryl hydrocarbon receptor Rattus norvegicus 4-33 10728779-1 2000 The aromatic hydrocarbon receptor (AHR) and AHR nuclear translocator protein (ARNT) mediate the toxic effects of a wide variety of halogenated and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 aryl hydrocarbon receptor Rattus norvegicus 35-38 10190573-3 1999 Since a number of polycyclic aromatic hydrocarbons (PAHs) also act as AHR-agonists, the CYP1A1-inducing potencies, measured as induction of 7-ethoxyresorufin O-deethylase (EROD) activity in rat hepatocyte cultures were analyzed for 16 PAHs frequently present in environmental samples. Polycyclic Aromatic Hydrocarbons 52-56 aryl hydrocarbon receptor Rattus norvegicus 70-73 1316759-3 1992 PAH-induced expression of the CYP1A1 gene appears to be regulated by several trans-acting factors, including the Ah receptor and the 4S PAH-binding protein. Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Rattus norvegicus 113-124 11097088-2 2000 In animals, PAH induce tumors in part by activating the aryl hydrocarbon receptor (AhR)/transcription factor. Polycyclic Aromatic Hydrocarbons 12-15 aryl hydrocarbon receptor Rattus norvegicus 56-81 11097088-2 2000 In animals, PAH induce tumors in part by activating the aryl hydrocarbon receptor (AhR)/transcription factor. Polycyclic Aromatic Hydrocarbons 12-15 aryl hydrocarbon receptor Rattus norvegicus 83-86 11097088-3 2000 Historically, investigations into AhR-regulated carcinogenesis have focused on AhR-dependent transcriptional regulation of cytochrome P450 (CYP) enzymes which oxidize PAH to mutagenic intermediates. Polycyclic Aromatic Hydrocarbons 167-170 aryl hydrocarbon receptor Rattus norvegicus 34-37 11097088-3 2000 Historically, investigations into AhR-regulated carcinogenesis have focused on AhR-dependent transcriptional regulation of cytochrome P450 (CYP) enzymes which oxidize PAH to mutagenic intermediates. Polycyclic Aromatic Hydrocarbons 167-170 aryl hydrocarbon receptor Rattus norvegicus 79-82 11097088-5 2000 Given the postulated role of the AhR in carcinogenesis, we predicted that: (1) tissue predisposed to PAH tumorigenesis would express the AhR and (2) aberrant AhR and/or AhR-regulated gene expression would accompany malignant transformation. Polycyclic Aromatic Hydrocarbons 101-104 aryl hydrocarbon receptor Rattus norvegicus 33-36 11097088-5 2000 Given the postulated role of the AhR in carcinogenesis, we predicted that: (1) tissue predisposed to PAH tumorigenesis would express the AhR and (2) aberrant AhR and/or AhR-regulated gene expression would accompany malignant transformation. Polycyclic Aromatic Hydrocarbons 101-104 aryl hydrocarbon receptor Rattus norvegicus 137-140 11097088-5 2000 Given the postulated role of the AhR in carcinogenesis, we predicted that: (1) tissue predisposed to PAH tumorigenesis would express the AhR and (2) aberrant AhR and/or AhR-regulated gene expression would accompany malignant transformation. Polycyclic Aromatic Hydrocarbons 101-104 aryl hydrocarbon receptor Rattus norvegicus 137-140 11097088-5 2000 Given the postulated role of the AhR in carcinogenesis, we predicted that: (1) tissue predisposed to PAH tumorigenesis would express the AhR and (2) aberrant AhR and/or AhR-regulated gene expression would accompany malignant transformation. Polycyclic Aromatic Hydrocarbons 101-104 aryl hydrocarbon receptor Rattus norvegicus 137-140 11097088-12 2000 These results: (1) help explain targeting of breast tissue by carcinogenic PAH, (2) imply that AhR and CYP1B1 hyper-expression represent molecular biomarkers for, at least, PAH-induced mammary cell transformation, and (3) suggest mechanisms through which the AhR may contribute to carcinogenesis well after exogenous AhR ligands have been eliminated. Polycyclic Aromatic Hydrocarbons 173-176 aryl hydrocarbon receptor Rattus norvegicus 95-98 11097088-12 2000 These results: (1) help explain targeting of breast tissue by carcinogenic PAH, (2) imply that AhR and CYP1B1 hyper-expression represent molecular biomarkers for, at least, PAH-induced mammary cell transformation, and (3) suggest mechanisms through which the AhR may contribute to carcinogenesis well after exogenous AhR ligands have been eliminated. Polycyclic Aromatic Hydrocarbons 173-176 aryl hydrocarbon receptor Rattus norvegicus 259-262 11097088-12 2000 These results: (1) help explain targeting of breast tissue by carcinogenic PAH, (2) imply that AhR and CYP1B1 hyper-expression represent molecular biomarkers for, at least, PAH-induced mammary cell transformation, and (3) suggest mechanisms through which the AhR may contribute to carcinogenesis well after exogenous AhR ligands have been eliminated. Polycyclic Aromatic Hydrocarbons 173-176 aryl hydrocarbon receptor Rattus norvegicus 259-262 9804617-1 1998 Cytochrome P450 1B1 (CYP1B1), which actively metabolizes polycyclic aromatic hydrocarbons, is regulated by the aryl hydrocarbon receptor (AhR) in primary cultures of rat mammary fibroblasts (RMF) and rat embryo fibroblasts (REF). Polycyclic Aromatic Hydrocarbons 57-89 aryl hydrocarbon receptor Rattus norvegicus 111-136 9804617-1 1998 Cytochrome P450 1B1 (CYP1B1), which actively metabolizes polycyclic aromatic hydrocarbons, is regulated by the aryl hydrocarbon receptor (AhR) in primary cultures of rat mammary fibroblasts (RMF) and rat embryo fibroblasts (REF). Polycyclic Aromatic Hydrocarbons 57-89 aryl hydrocarbon receptor Rattus norvegicus 138-141 9067484-1 1997 The aromatic hydrocarbon (AH) receptor mediates the induction of cytochromes P-450 (CYP) of the CYP1A subfamily caused by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 122-154 aryl hydrocarbon receptor Rattus norvegicus 4-38 9067484-1 1997 The aromatic hydrocarbon (AH) receptor mediates the induction of cytochromes P-450 (CYP) of the CYP1A subfamily caused by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 156-160 aryl hydrocarbon receptor Rattus norvegicus 4-38 9067484-3 1997 We performed a structure-activity relationship study with a series of PAHs of the anthracene class in order to determine if the AH receptor is involved in CYP2C11 down-regulation. Polycyclic Aromatic Hydrocarbons 70-74 aryl hydrocarbon receptor Rattus norvegicus 128-139 2372874-1 1990 The polycyclic aromatic hydrocarbon (PAH)-induced expression of the rat Cyp1A1 gene is a complex process which appears to be regulated by several trans-acting factors including the 8S (Ah receptor) and 4S PAH binding proteins. Polycyclic Aromatic Hydrocarbons 37-40 aryl hydrocarbon receptor Rattus norvegicus 185-196 2171791-9 1990 The results suggest that the synergistic effect of DEX and polycyclic aromatic hydrocarbons on P450IA1 induction involves a time-consuming process which may consist of the synthesis or modification of a factor, possibly the Ah receptor. Polycyclic Aromatic Hydrocarbons 59-91 aryl hydrocarbon receptor Rattus norvegicus 224-235 2157855-2 1990 At least two distinct high-affinity binding proteins may regulate its expression, the 4S protein that primarily binds polycyclic aromatic hydrocarbons (PAHs), and the 8S Ah receptor that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and like congeners. Polycyclic Aromatic Hydrocarbons 118-150 aryl hydrocarbon receptor Rattus norvegicus 170-181 2157855-2 1990 At least two distinct high-affinity binding proteins may regulate its expression, the 4S protein that primarily binds polycyclic aromatic hydrocarbons (PAHs), and the 8S Ah receptor that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and like congeners. Polycyclic Aromatic Hydrocarbons 152-156 aryl hydrocarbon receptor Rattus norvegicus 170-181