PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22167199-9 2012 This beta2ADR-dependent signaling pathway activated by PAHs may likely be crucial for PAH-mediated up-regulation of AhR target genes, thus suggesting a contribution of beta2ADR to the health-threatening effects of these environmental pollutants. Polycyclic Aromatic Hydrocarbons 55-58 adrenoceptor beta 2 Homo sapiens 5-13 22167199-9 2012 This beta2ADR-dependent signaling pathway activated by PAHs may likely be crucial for PAH-mediated up-regulation of AhR target genes, thus suggesting a contribution of beta2ADR to the health-threatening effects of these environmental pollutants. Polycyclic Aromatic Hydrocarbons 55-58 adrenoceptor beta 2 Homo sapiens 168-176 21617201-5 2011 We hypothesized that exposure to PAH might similarly interfere with the function of beta(2)AR in airway epithelial or smooth muscle cells, reducing the efficacy of a medication important for the treatment of asthma symptoms. Polycyclic Aromatic Hydrocarbons 33-36 adrenoceptor beta 2 Homo sapiens 84-93 21617201-8 2011 Murine tracheal epithelial cells and human airway smooth muscle cells, after exposure to a PAH mixture, exhibited reduced expression and function of beta(2)AR. Polycyclic Aromatic Hydrocarbons 91-94 adrenoceptor beta 2 Homo sapiens 149-158 21617201-9 2011 These findings support our hypothesis that environmentally relevant PAHs can impede beta(2)AR-mediated airway relaxation, and suggest a new paradigm where air pollutants not only contribute to the pathogenesis of childhood asthma, but also diminish responsiveness to standard therapy. Polycyclic Aromatic Hydrocarbons 68-72 adrenoceptor beta 2 Homo sapiens 84-93