PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23542445-2 2013 A significant part of these toxic effects is linked to the binding of some pollutants (like polycyclic aromatic hydrocarbons or PAHs) to the Aryl hydrocarbon Receptor (AhR) and the activation of target genes, like the cytochrome P4501A. Polycyclic Aromatic Hydrocarbons 92-124 aryl hydrocarbon receptor 1a Danio rerio 141-166 23542445-2 2013 A significant part of these toxic effects is linked to the binding of some pollutants (like polycyclic aromatic hydrocarbons or PAHs) to the Aryl hydrocarbon Receptor (AhR) and the activation of target genes, like the cytochrome P4501A. Polycyclic Aromatic Hydrocarbons 92-124 aryl hydrocarbon receptor 1a Danio rerio 168-171 23542445-2 2013 A significant part of these toxic effects is linked to the binding of some pollutants (like polycyclic aromatic hydrocarbons or PAHs) to the Aryl hydrocarbon Receptor (AhR) and the activation of target genes, like the cytochrome P4501A. Polycyclic Aromatic Hydrocarbons 128-132 aryl hydrocarbon receptor 1a Danio rerio 141-166 23542445-2 2013 A significant part of these toxic effects is linked to the binding of some pollutants (like polycyclic aromatic hydrocarbons or PAHs) to the Aryl hydrocarbon Receptor (AhR) and the activation of target genes, like the cytochrome P4501A. Polycyclic Aromatic Hydrocarbons 128-132 aryl hydrocarbon receptor 1a Danio rerio 168-171 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 64-95 aryl hydrocarbon receptor 1a Danio rerio 146-171 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 64-95 aryl hydrocarbon receptor 1a Danio rerio 173-176 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 64-95 aryl hydrocarbon receptor 1a Danio rerio 219-222 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 97-100 aryl hydrocarbon receptor 1a Danio rerio 146-171 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 97-100 aryl hydrocarbon receptor 1a Danio rerio 173-176 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 97-100 aryl hydrocarbon receptor 1a Danio rerio 219-222 19233942-2 2009 We previously reported that certain combinations of PAHs cause synergistic developmental toxicity, as observed with coexposure to the aryl hydrocarbon receptor agonist beta-naphthoflavone (BNF) and cytochrome P4501A inhibitor alpha-naphthoflavone (ANF). Polycyclic Aromatic Hydrocarbons 52-56 aryl hydrocarbon receptor 1a Danio rerio 134-159 19209607-2 2009 Previous studies using zebrafish demonstrated that crude oil exposure causes cardiogenic edema, and that the most abundant polycyclic aromatic hydrocarbons (PAHs) in weathered crude oils (tricyclic fluorenes, dibenzothiophenes, and phenanthrenes) are cardiotoxic, causing arrhythmia through a pathway that does not require activation of the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 157-161 aryl hydrocarbon receptor 1a Danio rerio 341-366 19209607-2 2009 Previous studies using zebrafish demonstrated that crude oil exposure causes cardiogenic edema, and that the most abundant polycyclic aromatic hydrocarbons (PAHs) in weathered crude oils (tricyclic fluorenes, dibenzothiophenes, and phenanthrenes) are cardiotoxic, causing arrhythmia through a pathway that does not require activation of the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 157-161 aryl hydrocarbon receptor 1a Danio rerio 368-371 17112560-2 2006 For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) "nonpolar narcosis", in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers. Polycyclic Aromatic Hydrocarbons 21-24 aryl hydrocarbon receptor 1a Danio rerio 155-180 17112560-2 2006 For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) "nonpolar narcosis", in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers. Polycyclic Aromatic Hydrocarbons 21-24 aryl hydrocarbon receptor 1a Danio rerio 182-185 17112560-3 2006 As part of a systematic analysis of mechanisms of PAH developmental toxicity in zebrafish, we show here that three tetracyclic PAHs (pyrene, chrysene, and benz[a]anthracene) activate the AHR pathway tissue-specifically to induce distinct patterns of CYP1A expression. Polycyclic Aromatic Hydrocarbons 50-53 aryl hydrocarbon receptor 1a Danio rerio 187-190 17112560-3 2006 As part of a systematic analysis of mechanisms of PAH developmental toxicity in zebrafish, we show here that three tetracyclic PAHs (pyrene, chrysene, and benz[a]anthracene) activate the AHR pathway tissue-specifically to induce distinct patterns of CYP1A expression. Polycyclic Aromatic Hydrocarbons 127-131 aryl hydrocarbon receptor 1a Danio rerio 187-190 17112560-6 2006 Therefore, biological effects of PAHs cannot be predicted simply by quantitative measures of AHR activity or a compound"s hydrophobicity. Polycyclic Aromatic Hydrocarbons 33-37 aryl hydrocarbon receptor 1a Danio rerio 93-96 16687390-0 2006 The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Polycyclic Aromatic Hydrocarbons 101-133 aryl hydrocarbon receptor 1a Danio rerio 16-41 16687390-3 2006 Another class of AHR agonists of increasing concern because of their known toxicity and ubiquity in the environment is the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 123-155 aryl hydrocarbon receptor 1a Danio rerio 17-20 16687390-3 2006 Another class of AHR agonists of increasing concern because of their known toxicity and ubiquity in the environment is the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 157-161 aryl hydrocarbon receptor 1a Danio rerio 17-20 16687390-7 2006 As observed in previous studies with killifish (Fundulus heteroclitus), we demonstrate here that coexposure of zebrafish (Danio rerio) embryos to the PAH-type AHR agonist beta-naphthoflavone (BNF) and the CYP1A inhibitor alpha-naphthoflavone (ANF) significantly enhanced toxicity above that observed for single-compound exposures. Polycyclic Aromatic Hydrocarbons 150-153 aryl hydrocarbon receptor 1a Danio rerio 159-162 16687390-8 2006 In order to elucidate the role of the AHR pathway in mediating synergistic toxicity of PAH mixtures to early life stages, we used a morpholino approach to knock down expression of zebrafish AHR2 and CYP1A proteins during development. Polycyclic Aromatic Hydrocarbons 87-90 aryl hydrocarbon receptor 1a Danio rerio 38-41 15183118-1 2004 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that can be activated by a diverse synthetic and naturally-occurring chemicals, such as the halogenated aromatic hydrocarbons (HAHs) and the non-halogenated polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 236-268 aryl hydrocarbon receptor 1a Danio rerio 4-29 15183118-1 2004 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that can be activated by a diverse synthetic and naturally-occurring chemicals, such as the halogenated aromatic hydrocarbons (HAHs) and the non-halogenated polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 236-268 aryl hydrocarbon receptor 1a Danio rerio 31-34 15183118-1 2004 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that can be activated by a diverse synthetic and naturally-occurring chemicals, such as the halogenated aromatic hydrocarbons (HAHs) and the non-halogenated polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 270-274 aryl hydrocarbon receptor 1a Danio rerio 4-29 15183118-1 2004 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that can be activated by a diverse synthetic and naturally-occurring chemicals, such as the halogenated aromatic hydrocarbons (HAHs) and the non-halogenated polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 270-274 aryl hydrocarbon receptor 1a Danio rerio 31-34 35377459-1 2022 The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and TCDD. Polycyclic Aromatic Hydrocarbons 131-163 aryl hydrocarbon receptor 1a Danio rerio 4-29 35377459-1 2022 The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and TCDD. Polycyclic Aromatic Hydrocarbons 131-163 aryl hydrocarbon receptor 1a Danio rerio 31-34 35377459-1 2022 The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and TCDD. Polycyclic Aromatic Hydrocarbons 165-169 aryl hydrocarbon receptor 1a Danio rerio 4-29 35377459-1 2022 The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and TCDD. Polycyclic Aromatic Hydrocarbons 165-169 aryl hydrocarbon receptor 1a Danio rerio 31-34 32615350-10 2020 Altogether, these data support that similar to interactions between PAHs, mixtures of PAHs and oxy-PAHs may cause increased developmental and cardiovascular toxicity in ZFEs through an AhR-dependent mechanism. Polycyclic Aromatic Hydrocarbons 68-72 aryl hydrocarbon receptor 1a Danio rerio 185-188 32615350-10 2020 Altogether, these data support that similar to interactions between PAHs, mixtures of PAHs and oxy-PAHs may cause increased developmental and cardiovascular toxicity in ZFEs through an AhR-dependent mechanism. Polycyclic Aromatic Hydrocarbons 86-90 aryl hydrocarbon receptor 1a Danio rerio 185-188 32384158-1 2020 The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 142-146 aryl hydrocarbon receptor 1a Danio rerio 31-34 32384158-1 2020 The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 108-140 aryl hydrocarbon receptor 1a Danio rerio 4-29 32384158-1 2020 The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 108-140 aryl hydrocarbon receptor 1a Danio rerio 31-34 32384158-1 2020 The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 142-146 aryl hydrocarbon receptor 1a Danio rerio 4-29 25532870-1 2015 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 160-192 aryl hydrocarbon receptor 1a Danio rerio 4-29 25532870-1 2015 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 160-192 aryl hydrocarbon receptor 1a Danio rerio 31-34 25532870-1 2015 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 194-198 aryl hydrocarbon receptor 1a Danio rerio 4-29 25532870-1 2015 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 194-198 aryl hydrocarbon receptor 1a Danio rerio 31-34 25715055-0 2015 Aryl hydrocarbon receptor activation and developmental toxicity in zebrafish in response to soil extracts containing unsubstituted and oxygenated PAHs. Polycyclic Aromatic Hydrocarbons 146-150 aryl hydrocarbon receptor 1a Danio rerio 0-25 25412620-2 2015 The aryl hydrocarbon receptor (AHR) mediates the toxicity of some PAHs. Polycyclic Aromatic Hydrocarbons 66-70 aryl hydrocarbon receptor 1a Danio rerio 4-29 25412620-2 2015 The aryl hydrocarbon receptor (AHR) mediates the toxicity of some PAHs. Polycyclic Aromatic Hydrocarbons 66-70 aryl hydrocarbon receptor 1a Danio rerio 31-34 24084256-0 2013 Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. Polycyclic Aromatic Hydrocarbons 45-48 aryl hydrocarbon receptor 1a Danio rerio 13-18 24084256-4 2013 In this study, we sought to explore the role of the two AHR1 isoforms in PAH- and PCB-induced toxicity in zebrafish embryos utilizing morpholino gene knockdown of the AHR isoforms. Polycyclic Aromatic Hydrocarbons 73-76 aryl hydrocarbon receptor 1a Danio rerio 56-60 24084256-4 2013 In this study, we sought to explore the role of the two AHR1 isoforms in PAH- and PCB-induced toxicity in zebrafish embryos utilizing morpholino gene knockdown of the AHR isoforms. Polycyclic Aromatic Hydrocarbons 73-76 aryl hydrocarbon receptor 1a Danio rerio 56-59 24084256-5 2013 Knockdown of AHR1B did not affect the toxicity of PAH mixtures or PCB-126, whereas knockdown of AHR1A exacerbated the cardiac toxicity caused by PAH mixtures and PCB-126. Polycyclic Aromatic Hydrocarbons 145-148 aryl hydrocarbon receptor 1a Danio rerio 96-101