PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33129239-8 2021 Conclusion: We found a significant association of OGG1 heterozygous (wt/mt) and homozygous (mt/mt) variants with oxidative and genotoxic damage, suggesting that these polymorphisms may modulate the effects of polycyclic aromatic hydrocarbons exposure in occupational workers. Polycyclic Aromatic Hydrocarbons 209-241 8-oxoguanine DNA glycosylase Homo sapiens 50-54 30807913-2 2019 This study aimed to quantify the associations of 8-oxoguanine DNA glycosylase (OGG1) methylation with urinary PAHs metabolites, DNA damage and cell cycle arrest, and further to assess the role of OGG1 methylation in mediating the association of urinary PAHs metabolites with DNA damage and cell cycle arrest. Polycyclic Aromatic Hydrocarbons 110-114 8-oxoguanine DNA glycosylase Homo sapiens 49-77 30807913-2 2019 This study aimed to quantify the associations of 8-oxoguanine DNA glycosylase (OGG1) methylation with urinary PAHs metabolites, DNA damage and cell cycle arrest, and further to assess the role of OGG1 methylation in mediating the association of urinary PAHs metabolites with DNA damage and cell cycle arrest. Polycyclic Aromatic Hydrocarbons 110-114 8-oxoguanine DNA glycosylase Homo sapiens 79-83 30807913-2 2019 This study aimed to quantify the associations of 8-oxoguanine DNA glycosylase (OGG1) methylation with urinary PAHs metabolites, DNA damage and cell cycle arrest, and further to assess the role of OGG1 methylation in mediating the association of urinary PAHs metabolites with DNA damage and cell cycle arrest. Polycyclic Aromatic Hydrocarbons 253-257 8-oxoguanine DNA glycosylase Homo sapiens 79-83 18569589-3 2008 This study aimed to develop a LightCycler (LC) assay to analyze the C>G polymorphism (Ser326Cys) in exon 7 of the hOGG1 gene followed by validation of the method using DNA samples from 260 polycyclic aromatic hydrocarbons(PAH)-exposed workers with known 8-oxodGuo DNA-adduct values measured by HPLC. Polycyclic Aromatic Hydrocarbons 192-224 8-oxoguanine DNA glycosylase Homo sapiens 117-122 18569589-3 2008 This study aimed to develop a LightCycler (LC) assay to analyze the C>G polymorphism (Ser326Cys) in exon 7 of the hOGG1 gene followed by validation of the method using DNA samples from 260 polycyclic aromatic hydrocarbons(PAH)-exposed workers with known 8-oxodGuo DNA-adduct values measured by HPLC. Polycyclic Aromatic Hydrocarbons 225-228 8-oxoguanine DNA glycosylase Homo sapiens 117-122 18569589-5 2008 LC melting curve analyses of the hOGG1 exon 7 PCR product were characteristic of the probes hybridized to the non-mutated Ser-type (CC) at 65 degrees C, or to the Cys mutant (GG) at 59 degrees C. The distribution in the population of PAH-exposed workers (N=260) was 58% (CC), 38%(CG), and 4% (GG). Polycyclic Aromatic Hydrocarbons 234-237 8-oxoguanine DNA glycosylase Homo sapiens 33-38 15284179-0 2004 Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions. Polycyclic Aromatic Hydrocarbons 97-100 8-oxoguanine DNA glycosylase Homo sapiens 42-46