PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 99-103 NFE2 like bZIP transcription factor 2 Homo sapiens 230-273 31628065-5 2019 RESULTS: We observed an increased expression of oxidative stress response protein NRF2, upon chronic exposure of primary keratinocytes to DPE/ its vapor which includes volatile components such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 196-228 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 31628065-5 2019 RESULTS: We observed an increased expression of oxidative stress response protein NRF2, upon chronic exposure of primary keratinocytes to DPE/ its vapor which includes volatile components such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 230-234 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 30904656-7 2019 Children with particle-bound PAH exposures have a relatively high health risk of aryl hydrocarbon receptor (AhR)-mediated adverse outcomes than adults, in particular in the winter period, while the activations of Nrf2 and p53 pathways are insignificant. Polycyclic Aromatic Hydrocarbons 29-32 NFE2 like bZIP transcription factor 2 Homo sapiens 213-217 29857962-5 2018 RESULTS: We observed an increased expression of oxidative stress response protein NRF2, upon chronic exposure of primary keratinocytes to DPE/its vapor which includes volatile components such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 195-227 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 29857962-5 2018 RESULTS: We observed an increased expression of oxidative stress response protein NRF2, upon chronic exposure of primary keratinocytes to DPE/its vapor which includes volatile components such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 229-233 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 27806574-3 2017 Although these enzymes play clear cytoprotective roles and deal effectively with carbonyl stress, their upregulation by the Keap1/Nrf2 pathway also has a potential dark-side, which can lead to chemotherapeutic drug resistance and the metabolic activation of lung carcinogens (e.g., polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 282-314 NFE2 like bZIP transcription factor 2 Homo sapiens 130-134 25564368-9 2016 We found positive associations of traffic-related pollutants (EC, BC, primary organic carbon, PM 0.25-2.5 PAH and/or PM 0.25 PAH, and NOx) with NFE2L2, Nrf2-mediated genes (HMOX1, NQO1, and SOD2), CYP1B1, IL1B, and SELP. Polycyclic Aromatic Hydrocarbons 106-109 NFE2 like bZIP transcription factor 2 Homo sapiens 144-150 25564368-9 2016 We found positive associations of traffic-related pollutants (EC, BC, primary organic carbon, PM 0.25-2.5 PAH and/or PM 0.25 PAH, and NOx) with NFE2L2, Nrf2-mediated genes (HMOX1, NQO1, and SOD2), CYP1B1, IL1B, and SELP. Polycyclic Aromatic Hydrocarbons 125-128 NFE2 like bZIP transcription factor 2 Homo sapiens 144-150 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 65-97 NFE2 like bZIP transcription factor 2 Homo sapiens 230-273 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 65-97 NFE2 like bZIP transcription factor 2 Homo sapiens 275-279 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 99-103 NFE2 like bZIP transcription factor 2 Homo sapiens 275-279 21753779-10 2012 In conclusion, the engagement of AhR by KCZ exhibits the cytoprotective effect mediated by the Nrf2 redox system, which potently downregulates either cytokine-induced (AhR-independent) or PAH-induced (AhR-dependent) oxidative stress. Polycyclic Aromatic Hydrocarbons 188-191 NFE2 like bZIP transcription factor 2 Homo sapiens 95-99 19367423-7 2010 Therefore, we have reviewed the scientific literature in order to indicate that air pollutants, such as particulate matter, polycyclic aromatic hydrocarbons, and gaseous matter, are Nrf2 pathway inductors, triggering self-defense through the establishment of proinflammatory and antioxidant responses. Polycyclic Aromatic Hydrocarbons 124-156 NFE2 like bZIP transcription factor 2 Homo sapiens 182-186 26122708-3 2015 Activation of Nrf2 can, however, serve as a double-edged sword because some of the genes it induces may contribute to chemical carcinogenesis by promoting futile redox cycling of polycyclic aromatic hydrocarbon metabolites or confer resistance to chemotherapeutic drugs by increasing the expression of efflux pumps, suggesting its cytoprotective effects will vary in a context-specific fashion. Polycyclic Aromatic Hydrocarbons 179-210 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18