PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23274566-2	2013	Non-additive PAH interactions have been observed in regulation of cytochrome P450 (CYP) gene expression in the CYP1 family.	Polycyclic Aromatic Hydrocarbons	13-16	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	66-81	
23274566-2	2013	Non-additive PAH interactions have been observed in regulation of cytochrome P450 (CYP) gene expression in the CYP1 family.	Polycyclic Aromatic Hydrocarbons	13-16	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	83-86	
23151208-2	2013	There are numerous similarities between the patterns of cytochrome P-450 (P450) activation of DBC and its covalent binding to DNA and proteins with another polycyclic aromatic hydrocarbon (PAH), 7,12-dimethylbenz[a]anthracene (DMBA).	Polycyclic Aromatic Hydrocarbons	156-187	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	56-78	
23151208-2	2013	There are numerous similarities between the patterns of cytochrome P-450 (P450) activation of DBC and its covalent binding to DNA and proteins with another polycyclic aromatic hydrocarbon (PAH), 7,12-dimethylbenz[a]anthracene (DMBA).	Polycyclic Aromatic Hydrocarbons	189-192	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	56-78	
8844979-1	1996	The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes.	Polycyclic Aromatic Hydrocarbons	41-73	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	226-257	
8844979-1	1996	The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes.	Polycyclic Aromatic Hydrocarbons	75-78	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	226-257	
2912553-2	1989	A major form of cytochrome P-450 was purified from skin microsomes of mice treated with polycyclic aromatic hydrocarbon.	Polycyclic Aromatic Hydrocarbons	88-119	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	16-32	
3593412-5	1987	7-Ethoxyresorufin and acetanilide, selective substrates for two polycyclic aromatic hydrocarbon (PAH)-inducible isozymes of cytochrome P-450 in the mouse (P1-450 and P3-450, respectively) were each able to inhibit competitively the formation of caffeine metabolites by human liver microsomes, while caffeine could in turn similarly inhibit the biotransformations of these two compounds.	Polycyclic Aromatic Hydrocarbons	64-95	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	124-140	
3593412-5	1987	7-Ethoxyresorufin and acetanilide, selective substrates for two polycyclic aromatic hydrocarbon (PAH)-inducible isozymes of cytochrome P-450 in the mouse (P1-450 and P3-450, respectively) were each able to inhibit competitively the formation of caffeine metabolites by human liver microsomes, while caffeine could in turn similarly inhibit the biotransformations of these two compounds.	Polycyclic Aromatic Hydrocarbons	97-100	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	124-140	
19900403-2	2009	Cytochrome P450 (CYP)1A enzymes play key roles in the metabolic activation of PAHs to carcinogenic metabolites.	Polycyclic Aromatic Hydrocarbons	78-82	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-23	
18353537-3	2008	We evaluated the influence of diesel exhaust particulate matter on PAH-induced cytochrome P450 (CYP) activity, PAH-DNA adduct formation, expression of certain candidate genes and the frequency of tumor initiation in the two-stage Sencar mouse model.	Polycyclic Aromatic Hydrocarbons	67-70	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	79-94	
14720319-3	2004	Cytochrome P450 (CYP) enzymes are central to the metabolic activation of these PAHs to epoxide intermediates, which are converted with the aid of epoxide hydrolase to the ultimate carcinogens, diol-epoxides.	Polycyclic Aromatic Hydrocarbons	79-83	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-15	
14720319-3	2004	Cytochrome P450 (CYP) enzymes are central to the metabolic activation of these PAHs to epoxide intermediates, which are converted with the aid of epoxide hydrolase to the ultimate carcinogens, diol-epoxides.	Polycyclic Aromatic Hydrocarbons	79-83	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	17-20	
6638486-2	1983	Two of the ethylfluoresceins are specifically metabolized by the polycyclic aromatic hydrocarbon inducible cytochrome P-450 to yield fluorescein, which is about 15 times more fluorescent than the ethylated compounds.	Polycyclic Aromatic Hydrocarbons	65-96	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	107-123