PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3276319-8 1988 Thus the enantiomeric composition of a metabolically formed dihydrodiol is determined by (i) the stereoselective epoxidation at a formal double bond of a parent hydrocarbon by microsomal cytochrome P-450 isozymes and (ii) the enantioselective and regioselective hydration of the metabolically formed epoxide by microsomal epoxide hydrolase. trans-1,2-dihydro-1,2-naphthalenediol 60-71 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 187-203 27299-2 1978 The yield of the dihydrodiol was maximal at pH 6.5, was reduced nicotinmide adenine dinucleotide phosphate- and cytochrome P-450-dependent, and was increased 2- to 4-fold by pretreatment of the animals with phenobarbital; pretreatment with 3-methylcholanthrene did not alter the activity of rat hepatic microsomes. trans-1,2-dihydro-1,2-naphthalenediol 17-28 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 112-128