PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1898024-5 1991 With either enantiomer of triphenylene 1,2-dihydrodiol, both purified cytochrome P450c (P450IA1) and liver microsomes from MC-treated rats formed diol epoxides and phenolic dihydrodiols in approximately equal amounts. trans-1,2-dihydro-1,2-naphthalenediol 173-185 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 70-86 21781864-5 1998 Stereoselective activation of B[c]Ph, the (+-)-B[c]Ph-3,4-dihydrodiol and its (-)-3R,4R-enantiomer to the fjord-region (-)-anti-B[c]PhDE occurred upon incubation with rat CYP1A1 and rat CYP1A2 as indicated by the formation of two stereoisomeric tetraols, the hydrolysis products of the labile anti-B[c]PhDE. trans-1,2-dihydro-1,2-naphthalenediol 58-69 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 171-177 10528997-2 1999 The dihydrodiol is metabolized at a rate of 2.4 nmol/nmol of cytochrome P450 1A1/min with microsomes from 3-methylcholanthrene-treated rats, a rate more than 10-fold higher than that observed with microsomes from control or phenobarbital-treated rats. trans-1,2-dihydro-1,2-naphthalenediol 4-15 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 61-80 3564534-6 1987 The 9,10-dihydro-9,10-dihydroxybenzo[a]pyrene was the major dihydrodiol formed by pulmonary cytochrome P-450MC. trans-1,2-dihydro-1,2-naphthalenediol 60-71 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 103-110 3564534-8 1987 Similar results concerning the related production of phenols and dihydrodiols, in the absence and presence of epoxide hydrolase, were obtained in reconstituted systems of hepatic cytochrome P-450MC, the major form of hepatic cytochrome P-450 from 3-methylcholanthrene-treated rats. trans-1,2-dihydro-1,2-naphthalenediol 65-77 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 190-197 6309378-6 1983 Benzo(a)pyrene was metabolized by AHH to dihydrodiols, quinones, and phenols in quantities which were about 10 times greater than those reported for rat lung microsomes. trans-1,2-dihydro-1,2-naphthalenediol 41-53 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 34-37 6865920-11 1983 The basis for this ratio in the latter case was explained by examination of the products formed from the (+)-(1S,2S)-and (-)-(1R,2R)-enantiomers of the dihydrodiol on metabolism by a highly purified system reconstituted with cytochrome P-450c. trans-1,2-dihydro-1,2-naphthalenediol 152-163 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 225-242 19330882-9 2009 The cytotoxicity of the dihydrodiol intermediates of B[a]P or DB[a,l]P was much greater, and similar in cell lines expressing either human or rat CYP1A1. trans-1,2-dihydro-1,2-naphthalenediol 24-35 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 146-152