PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16215179-9 2005 We propose a model for regulation of the ADE genes in which DNA-bound Bas1 is inactive due to masking of its activation domain and Pho2 binds poorly to promoters when cells have sufficient purine nucleotides. Purine Nucleotides 189-207 Pho2p Saccharomyces cerevisiae S288C 131-135 11689683-7 2001 We conclude that efficient transcription of yeast AMP biosynthesis genes requires interaction between Bas1p and Bas2p which is promoted in the presence of a metabolic intermediate whose synthesis is controlled by feedback inhibition of Ade4p acting as the purine nucleotide sensor within the cell. Purine Nucleotides 256-273 Pho2p Saccharomyces cerevisiae S288C 112-117