PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35239666-6	2022	Disruption of the inducible CTP synthase under DON exposure hyper-activates the Mec1-Rad53 DNA damage response (DDR) pathway, which prevents chromosome breakage.	Diazooxonorleucine	47-50	protein kinase MEC1	Saccharomyces cerevisiae S288C	80-84	
35239666-7	2022	Simultaneous inhibition of CTP synthase and Mec1 kinase synergistically sensitizes cells to DON, whereas CTP synthase over-expression hampers DDR mutant sensitivity.	Diazooxonorleucine	92-95	protein kinase MEC1	Saccharomyces cerevisiae S288C	44-48