PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16158611-2 2005 Ca2+ is a key second messenger that delivers signal from the cell surface, reactive oxygen intermediates and nitric oxide are recently recognized as important mediators of T cell activation. reactive 75-83 carbonic anhydrase 2 Homo sapiens 0-3