PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29964038-3	2018	UPP1-knockout mice have increased intestinal concentrations of uridine and Deoxyuridine triphosphate (dUTP), have increased uridine-induced DNA damage, and develop colon tumors.	Uridine	63-70	uridine phosphorylase 1	Mus musculus	0-4	
31296061-7	2019	Additionally, oral administration of uridine during daytime or nighttime changed the expression levels of genes involved in the metabolism of uridine (SLC29A1, UMPS, UPP, UGT1A1, and DHODH; P < .05).	Uridine	37-44	uridine phosphorylase 1	Mus musculus	166-169	
31296061-7	2019	Additionally, oral administration of uridine during daytime or nighttime changed the expression levels of genes involved in the metabolism of uridine (SLC29A1, UMPS, UPP, UGT1A1, and DHODH; P < .05).	Uridine	142-149	uridine phosphorylase 1	Mus musculus	166-169	
10519414-1	1999	Uridine phosphorylase (UPase) plays an important role in the activation of 5-fluorouracil and in the regulation of tissue and plasma concentration of uridine, a potential biochemical modulator of 5-fluorouracil therapy.	Uridine	150-157	uridine phosphorylase 1	Mus musculus	23-28	
29964038-3	2018	UPP1-knockout mice have increased intestinal concentrations of uridine and Deoxyuridine triphosphate (dUTP), have increased uridine-induced DNA damage, and develop colon tumors.	Uridine	80-87	uridine phosphorylase 1	Mus musculus	0-4	
29964038-13	2018	CONCLUSIONS: We found vitamin D to increase expression of UPP1, leading to reduce uridine-induced DNA damage, in colon cells and organoids.	Uridine	82-89	uridine phosphorylase 1	Mus musculus	58-62	
15772079-0	2005	Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene.	Uridine	17-24	uridine phosphorylase 1	Mus musculus	125-146	
26801745-4	2016	Targeted disruption (-/-) of murine uridine phosphorylase (UPase) disrupted the homeostasis of uridine and increased spontaneous tumorigenesis by more than 3-fold.	Uridine	36-43	uridine phosphorylase 1	Mus musculus	59-64	
24918436-7	2014	Some of the short-term effects of exogenous uridine in C57BL/6J mice are conserved in transgenic UPase1-/- mice with long-term elevation of endogenous uridine level.	Uridine	44-51	uridine phosphorylase 1	Mus musculus	97-103	
24918436-7	2014	Some of the short-term effects of exogenous uridine in C57BL/6J mice are conserved in transgenic UPase1-/- mice with long-term elevation of endogenous uridine level.	Uridine	151-158	uridine phosphorylase 1	Mus musculus	97-103	
23355744-2	2013	Hepatic microvesicular steatosis is induced by disruption of uridine homeostasis through transgenic overexpression of UPase1, an enzyme of the pyrimidine catabolism and salvage pathway.	Uridine	61-68	uridine phosphorylase 1	Mus musculus	118-124	
23355744-5	2013	The effective concentration (EC(50)) for uridine to suppress microvesicular steatosis is approximately 20 microM in primary hepatocytes of UPase1-TG mice.	Uridine	41-48	uridine phosphorylase 1	Mus musculus	139-145	
15772079-1	2005	We report in the present study the critical role of uridine phosphorylase (UPase) in uridine homeostatic regulation and pyrimidine nucleotide metabolism, employing newly developed UPase-/- mice.	Uridine	52-59	uridine phosphorylase 1	Mus musculus	75-80	
15772079-2	2005	Our data demonstrate that the abrogation of UPase activity led to greater than a 6-fold increase in uridine concentrations in plasma, a 5-6-fold increase in lung and gut, and a 2-3-fold increase in liver and kidney, as compared with wild type mice.	Uridine	100-107	uridine phosphorylase 1	Mus musculus	44-49	
15772079-3	2005	Urine uridine levels increased 24-fold normal in UPase-/- mice.	Uridine	6-13	uridine phosphorylase 1	Mus musculus	49-54	
15772079-5	2005	Further, in these UPase-/- mice, abnormal uridine metabolism led to disorders of various nucleotide metabolisms.	Uridine	42-49	uridine phosphorylase 1	Mus musculus	18-23	
15772079-12	2005	These data indicate that UPase is a critical enzyme in the regulation of uridine homeostasis and pyrimidine nucleotide metabolism, and 5-fluorouracil activity.	Uridine	73-80	uridine phosphorylase 1	Mus musculus	25-30	
11956089-4	2002	It has long been known that UPase regulates the plasma concentration of uridine; however, little is known of the role of UPase in the activation and metabolism of 5-FU and its derivatives, mainly because of the lack of an appropriate model system.	Uridine	72-79	uridine phosphorylase 1	Mus musculus	28-33