PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2853896-2 1988 Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-. Propylthiouracil 0-16 myeloperoxidase Rattus norvegicus 39-54 9146773-11 1997 Pre-treatment with either methimazole 0.04% or propylthiouracil 0.01% significantly decreased mucosal damage macroscopically (lesion area, lesion score and segmental weight) microscopically and also significantly decreased MPO level at both time points (P < 0.01). Propylthiouracil 47-63 myeloperoxidase Rattus norvegicus 223-226 2159305-0 1990 Mechanism of inactivation of myeloperoxidase by propylthiouracil. Propylthiouracil 48-64 myeloperoxidase Rattus norvegicus 29-44 2159305-1 1990 The mechanism of inactivation of myeloperoxidase purified from rat bone marrow by propylthiouracil (PTU) was studied. Propylthiouracil 82-98 myeloperoxidase Rattus norvegicus 33-48 2159305-1 1990 The mechanism of inactivation of myeloperoxidase purified from rat bone marrow by propylthiouracil (PTU) was studied. Propylthiouracil 100-103 myeloperoxidase Rattus norvegicus 33-48 2159305-2 1990 PTU inhibited not only the peroxidase activity but also the chlorinating activity of myeloperoxidase in a concentration dependent manner. Propylthiouracil 0-3 myeloperoxidase Rattus norvegicus 85-100 2159305-3 1990 When myeloperoxidase was treated with PTU and hydrogen peroxide (5 microM), inactivation of the enzyme was still observed after the excess reagents were removed by a column of Sephadex G-25. Propylthiouracil 38-41 myeloperoxidase Rattus norvegicus 5-20 2159305-5 1990 In addition, [14C]PTU became bound to myeloperoxidase in the presence of hydrogen peroxide. Propylthiouracil 18-21 myeloperoxidase Rattus norvegicus 38-53 2159305-7 1990 Difference spectrum of myeloperoxidase treated with PTU in the presence of a low concentration of hydrogen peroxide (5 microM) was similar to that of compound II. Propylthiouracil 52-55 myeloperoxidase Rattus norvegicus 23-38 2159305-8 1990 Therefore, these results indicate that PTU inactivates myeloperoxidase through binding to the enzyme and the conversion to a compound II-like form in the presence of hydrogen peroxide. Propylthiouracil 39-42 myeloperoxidase Rattus norvegicus 55-70 1850263-3 1991 Propylthiouracil, an inhibitor of myeloperoxidase, and Ca2+ chelators prevented activation of myeloperoxidase and phagocytosis by A23187. Propylthiouracil 0-16 myeloperoxidase Rattus norvegicus 34-49 1850263-3 1991 Propylthiouracil, an inhibitor of myeloperoxidase, and Ca2+ chelators prevented activation of myeloperoxidase and phagocytosis by A23187. Propylthiouracil 0-16 myeloperoxidase Rattus norvegicus 94-109 2853896-2 1988 Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-. Propylthiouracil 0-16 myeloperoxidase Rattus norvegicus 56-59 2853896-2 1988 Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-. Propylthiouracil 18-21 myeloperoxidase Rattus norvegicus 39-54 2853896-2 1988 Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-. Propylthiouracil 18-21 myeloperoxidase Rattus norvegicus 56-59 2853896-6 1988 The characteristics of PTU degradation by MPO-H2O2-Cl- were similar to those of the chlorinating activity of the peroxidase. Propylthiouracil 23-26 myeloperoxidase Rattus norvegicus 42-45 2853896-8 1988 Hypochlorous acid as well as MPO-H2O2-Cl- also degraded PTU. Propylthiouracil 56-59 myeloperoxidase Rattus norvegicus 29-32 2853896-9 1988 Metabolites of PTU degradation by MPO-H2O2-Cl-, which were separated by C18 reversed phase h.p.l.c., were the same as those produced by hypochlorous acid. Propylthiouracil 15-18 myeloperoxidase Rattus norvegicus 34-37 2853896-11 1988 Of the metabolites of PTU formed by MPO-H2O2-Cl-, one was identified as PTU sulphonic acid (6-propyl-4-hydroxypyrimidine-2-sulphonate) and another seemed to be propyluracil. Propylthiouracil 22-25 myeloperoxidase Rattus norvegicus 36-39 27406012-10 2017 After acute stress induction, increased MPO and MDA levels in heart and elevated MPO activity in liver were inhibited in PTU-treated HIE group. Propylthiouracil 121-124 myeloperoxidase Rattus norvegicus 40-43 2837228-1 1988 Myeloperoxidase and eosinophil peroxidase were isolated from the bone marrow cells of rats treated with or without propylthiouracil (PTU) which caused bone marrow depression. Propylthiouracil 115-131 myeloperoxidase Rattus norvegicus 0-15 2837228-1 1988 Myeloperoxidase and eosinophil peroxidase were isolated from the bone marrow cells of rats treated with or without propylthiouracil (PTU) which caused bone marrow depression. Propylthiouracil 133-136 myeloperoxidase Rattus norvegicus 0-15 2837228-4 1988 EPR spectra indicated that the structure of myeloperoxidase surrounding the heme iron changed from a rhombic form into an axial one by the repeated administration of PTU. Propylthiouracil 166-169 myeloperoxidase Rattus norvegicus 44-59 6096612-0 1984 Relationship between leukopenia and bone marrow myeloperoxidase in the rat treated with propylthiouracil. Propylthiouracil 88-104 myeloperoxidase Rattus norvegicus 48-63 6096612-1 1984 The relationship between the toxic effect of propylthiouracil (PTU) and myeloperoxidase activity of rat bone marrow was examined. Propylthiouracil 45-61 myeloperoxidase Rattus norvegicus 72-87 6096612-1 1984 The relationship between the toxic effect of propylthiouracil (PTU) and myeloperoxidase activity of rat bone marrow was examined. Propylthiouracil 63-66 myeloperoxidase Rattus norvegicus 72-87 6096612-2 1984 The administration of PTU for 1 or 2 weeks caused a decrease in leukocyte count with the concomitant inhibition of the activity of myeloperoxidase in the bone marrow. Propylthiouracil 22-25 myeloperoxidase Rattus norvegicus 131-146 6096612-6 1984 The results suggest that the mechanism of inhibition of myeloperoxidase activity by PTU given in vivo or incubated with the enzyme in vitro may be the same. Propylthiouracil 84-87 myeloperoxidase Rattus norvegicus 56-71 27406012-10 2017 After acute stress induction, increased MPO and MDA levels in heart and elevated MPO activity in liver were inhibited in PTU-treated HIE group. Propylthiouracil 121-124 myeloperoxidase Rattus norvegicus 81-84 27406012-11 2017 In MIE rats, increased MPO and declined GSH levels of the gastric tissue and small intestine, and elevated MDA levels of gastric tissue were reversed in PTU-treated MIE group. Propylthiouracil 153-156 myeloperoxidase Rattus norvegicus 23-26 22777766-0 2012 Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis. Propylthiouracil 50-66 myeloperoxidase Rattus norvegicus 183-198 22777766-3 2012 Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV). Propylthiouracil 0-16 myeloperoxidase Rattus norvegicus 74-77 22777766-3 2012 Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV). Propylthiouracil 0-16 myeloperoxidase Rattus norvegicus 136-139 22777766-3 2012 Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV). Propylthiouracil 0-16 myeloperoxidase Rattus norvegicus 136-139 22777766-3 2012 Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV). Propylthiouracil 18-21 myeloperoxidase Rattus norvegicus 74-77 22777766-3 2012 Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV). Propylthiouracil 18-21 myeloperoxidase Rattus norvegicus 136-139 22777766-3 2012 Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV). Propylthiouracil 18-21 myeloperoxidase Rattus norvegicus 136-139 22777766-4 2012 This study was undertaken to clarify the mechanism of MPO ANCA production, using the PTU-induced model of MPO AAV. Propylthiouracil 85-88 myeloperoxidase Rattus norvegicus 54-57 22777766-4 2012 This study was undertaken to clarify the mechanism of MPO ANCA production, using the PTU-induced model of MPO AAV. Propylthiouracil 85-88 myeloperoxidase Rattus norvegicus 106-109 22777766-11 2012 When rats were given oral PTU with intraperitoneal injection of PMA, pauci-immune glomerulonephritis and pulmonary capillaritis occurred with MPO ANCA production in the serum. Propylthiouracil 26-29 myeloperoxidase Rattus norvegicus 142-145