PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10928947-7	2000	The results suggest that the inhibitory actions of PTU on testosterone secretion are exerted, at least in part, at the testicular level through a mechanism which is independent of thyroid status and which involves a reduction in P450scc activity and, hence, in the conversion of cholesterol to pregnenolone.	Propylthiouracil	51-54	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	229-236	
12922945-8	2003	PTU (12 mM) inhibited the activities of both the cytochrome P450 side-chain cleavage enzyme (P450scc, conversion of 25-hydroxyl cholesterol to pregnenolone) and the 3beta-hydroxysteroid dehydrogenase (conversion of pregnenolone to progesterone) in rat granulosa cells.	Propylthiouracil	0-3	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	49-91	
12922945-8	2003	PTU (12 mM) inhibited the activities of both the cytochrome P450 side-chain cleavage enzyme (P450scc, conversion of 25-hydroxyl cholesterol to pregnenolone) and the 3beta-hydroxysteroid dehydrogenase (conversion of pregnenolone to progesterone) in rat granulosa cells.	Propylthiouracil	0-3	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	93-100	
12135875-8	2002	PTU inhibited pregnenolone production (i.e., it diminished the function of P450(scc) in Leydig cells).	Propylthiouracil	0-3	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	75-84	
12135875-10	2002	These results suggest that PTU acts directly on rat Leydig cells to diminish testosterone production by inhibiting P450(scc) function and StAR expression.	Propylthiouracil	27-30	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	115-124	
20924043-4	2010	Notably, we found that PTU treatment enhanced the conversion of cholesterol into pregnenolone, whereas the protein level of the cytochrome P450 side-chain cleavage enzyme (P450scc, which is the enzyme responding to this conversion) was not affected.	Propylthiouracil	23-26	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	172-179