PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10319936-2 1999 We studied the thyroids of Wistar rats treated with thyroxine (T4) or propylthiouracil (PTU), each of which modulates TSH levels, but affects follicular function and Tg accumulation in the follicular lumen very differently. Propylthiouracil 70-86 thyroglobulin Rattus norvegicus 166-168 10319936-2 1999 We studied the thyroids of Wistar rats treated with thyroxine (T4) or propylthiouracil (PTU), each of which modulates TSH levels, but affects follicular function and Tg accumulation in the follicular lumen very differently. Propylthiouracil 88-91 thyroglobulin Rattus norvegicus 166-168 2326285-1 1990 Experiments were performed both in vivo and in vitro to test a previous proposal that part of the antithyroid action of the thioureylene drugs, propylthiouracil (PTU) and methylmercaptoimidazole, can be attributed to inhibition of thyroglobulin (Tg) biosynthesis. Propylthiouracil 162-165 thyroglobulin Rattus norvegicus 231-244 1794603-0 1991 Methimazole and propylthiouracil increase thyroglobulin gene expression in FRTL-5 cells. Propylthiouracil 16-32 thyroglobulin Rattus norvegicus 42-55 1794603-1 1991 In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. Propylthiouracil 39-55 thyroglobulin Rattus norvegicus 114-127 1794603-1 1991 In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. Propylthiouracil 39-55 thyroglobulin Rattus norvegicus 129-131 1794603-1 1991 In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. Propylthiouracil 39-55 thyroglobulin Rattus norvegicus 149-151 1794603-1 1991 In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. Propylthiouracil 57-60 thyroglobulin Rattus norvegicus 114-127 1794603-1 1991 In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. Propylthiouracil 57-60 thyroglobulin Rattus norvegicus 129-131 1794603-1 1991 In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. Propylthiouracil 57-60 thyroglobulin Rattus norvegicus 149-151 1794603-2 1991 An increase in Tg mRNA levels and in Tg accumulation was observed after 2-4 h and 8 h incubation with 10,000 microM MMI or PTU, respectively. Propylthiouracil 123-126 thyroglobulin Rattus norvegicus 15-17 1794603-2 1991 An increase in Tg mRNA levels and in Tg accumulation was observed after 2-4 h and 8 h incubation with 10,000 microM MMI or PTU, respectively. Propylthiouracil 123-126 thyroglobulin Rattus norvegicus 37-39 12114793-0 1997 Effects of Propyithiouracil (PTU) Administration on the Synthesis and Secretion of Thyroglobulin in the Rat Thyroid Gland: A Quantitative Immuno-electron Microscopic Study Using Immunogold Technique. Propylthiouracil 29-32 thyroglobulin Rattus norvegicus 83-96 4018393-3 1985 On the other hand, in Tgb samples synthesized by propylthiouracil-blocked glands, the I:D regression is no longer linear. Propylthiouracil 49-65 thyroglobulin Rattus norvegicus 22-25 7355663-0 1980 Effects of propylthiouracil and methylmercaptoimidazole on thyroglobulin synthesis. Propylthiouracil 11-27 thyroglobulin Rattus norvegicus 59-72 6707550-1 1984 Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls. Propylthiouracil 68-86 thyroglobulin Rattus norvegicus 6-19 6707550-1 1984 Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls. Propylthiouracil 68-86 thyroglobulin Rattus norvegicus 21-23 6707550-1 1984 Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls. Propylthiouracil 88-91 thyroglobulin Rattus norvegicus 6-19 6707550-1 1984 Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls. Propylthiouracil 88-91 thyroglobulin Rattus norvegicus 21-23 6707550-3 1984 Thyroid cells prepared from T4-treated animals behaved similarly to cells from control rats, whereas in vitro basal release of Tg from thyroid cells prepared from PTU-treated animals was high and the response to TSH was lost. Propylthiouracil 163-166 thyroglobulin Rattus norvegicus 127-129 7355663-6 1980 In vitro studies demonstrate that PTU and MMI inhibit Tg biosynthesis which is impaired in the polypeptide synthesis as well as in carbohydrate chains addition. Propylthiouracil 34-37 thyroglobulin Rattus norvegicus 54-56 743306-0 1978 Isolation of thyroglobulin messenger RNA from rats: increased yield in propylthiouracil-induced hyperplasia. Propylthiouracil 71-87 thyroglobulin Rattus norvegicus 13-26 1138879-6 1975 In a second series of experiments extremely iodine-poor thyroglobulin (smaller than 0.005%) was obtained from propylthiouracil-treated rats. Propylthiouracil 110-126 thyroglobulin Rattus norvegicus 56-69 4955039-0 1965 [Influence of propylthiouracil on the biosynthesis of thyroglobulin and its precursors by surviving rat thyroid slices]. Propylthiouracil 14-30 thyroglobulin Rattus norvegicus 54-67