PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34234489-2 2021 Objective: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the efficacy of thymoquinone (TQ) in alleviating this impact and explore the mechanism behind it alleviating oxidative stress and affecting beta-catenin expression. Propylthiouracil 59-75 catenin beta 1 Rattus norvegicus 279-291 34234489-2 2021 Objective: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the efficacy of thymoquinone (TQ) in alleviating this impact and explore the mechanism behind it alleviating oxidative stress and affecting beta-catenin expression. Propylthiouracil 77-80 catenin beta 1 Rattus norvegicus 279-291 34234489-12 2021 Conclusion: TQ alleviated PTU-induced hypothyroidism changes in insulin homeostasis and pancreatic beta cells mostly through its antioxidant effect as well as up-regulation of pancreatic beta-catenin expression. Propylthiouracil 26-29 catenin beta 1 Rattus norvegicus 187-199