PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19069154-6	2008	Thiamazole (MMI), which was being given for Basedow disease for years, was withdrawn on the suspicion as a cause of MPO-ANCA.	Methimazole	0-10	myeloperoxidase	Homo sapiens	116-119	
16024637-4	2005	Methimazole, 4-aminobenzoic acid hydrazide, or azide inhibits the reaction, suggesting that it is mediated by the cellular myeloperoxidase, an enzyme naturally present in large amounts in HL-60 cells.	Methimazole	0-11	myeloperoxidase	Homo sapiens	123-138	
1664996-0	1991	Hydrogen peroxide-dependent oxidation metabolism of 1-methyl-2-mercaptoimidazole (methimazole) catalysed by myeloperoxidase.	Methimazole	52-80	myeloperoxidase	Homo sapiens	108-123	
16207347-3	2005	The presence of myeloperoxidase-antineutrophil cytoplasmic antibodies, IgM anticardiolipin antibody, and antihistone antibodies in combination was found to be characteristic of drug-induced vasculitic syndromes caused by the antithyroid drugs propylthiouracil and methimazol.	Methimazole	264-274	myeloperoxidase	Homo sapiens	16-31	
12201217-0	2002	Prevalence of serum anti-myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves" disease treated with propylthiouracil and thiamazole.	Methimazole	157-167	myeloperoxidase	Homo sapiens	80-83	
10801811-12	2000	When HL-60 cells were incubated with methimazole or 4-aminobenzoic acid hydrazide, which are inhibitors of myeloperoxidase, they no longer underwent H(2)O(2)-induced apoptosis.	Methimazole	37-48	myeloperoxidase	Homo sapiens	107-122	
9618427-7	1998	In the present study myeloperoxidase activity was inhibited fully at therapeutic concentrations by antithyroid drugs (propylthiouracil and methimazole).	Methimazole	139-150	myeloperoxidase	Homo sapiens	21-36	
8152263-7	1994	Acetaminophen, N-acetylcysteine, propylthiouracil, D-penicillamine, mefenamic acid, dapsone, and methimazole all inhibited MPO at clinically achievable concentrations.	Methimazole	97-108	myeloperoxidase	Homo sapiens	123-126	
1318692-11	1992	The thioureylene drugs, propylthiouracil and methimazole, inhibited MPO-catalyzed iodination both reversibly and irreversibly, in a manner similar to that previously described for TPO-catalyzed iodination.	Methimazole	45-56	myeloperoxidase	Homo sapiens	68-71	
1664996-0	1991	Hydrogen peroxide-dependent oxidation metabolism of 1-methyl-2-mercaptoimidazole (methimazole) catalysed by myeloperoxidase.	Methimazole	82-93	myeloperoxidase	Homo sapiens	108-123	
1664996-2	1991	Myeloperoxidase catalysed the H2O2-supported oxidation of 1-methyl-2-mercaptoimidazole (MMI) in the presence of Cl-.	Methimazole	58-86	myeloperoxidase	Homo sapiens	0-15	
1664996-2	1991	Myeloperoxidase catalysed the H2O2-supported oxidation of 1-methyl-2-mercaptoimidazole (MMI) in the presence of Cl-.	Methimazole	88-91	myeloperoxidase	Homo sapiens	0-15	
1664996-8	1991	When the H2O2/MMI ratio was 0.5, MMI was oxidized by hyochlorous acid produced by the myeloperoxidase-H2O2-Cl- system giving bis-(1-methyl-2-imidazolyl)disulphide (MMI-disulphide) as an initial product, which gradually underwent disproportionation and subsequent hydrolysis giving 1-methylimidazole and MMI as the final products stoichiometrically.	Methimazole	14-17	myeloperoxidase	Homo sapiens	86-101	
2836234-3	1988	Quercetin is significantly more potent than three other related compounds (rutin, rutin sulfate and troxerutin) and than methimazole, a previously-known myeloperoxidase inhibitor.	Methimazole	121-132	myeloperoxidase	Homo sapiens	153-168	
89704-6	1979	The antithyroid drug methylmercapto-imidazole (MMI) inhibited in vitro MPO-catalysed 131I delabelling of 131I-DIT at all concentrations between 10(-7) and 10(-2)M, whereas 131I-T4 delabelling was markedly stimulated at the same drug concentrations.	Methimazole	21-45	myeloperoxidase	Homo sapiens	71-74	
89704-6	1979	The antithyroid drug methylmercapto-imidazole (MMI) inhibited in vitro MPO-catalysed 131I delabelling of 131I-DIT at all concentrations between 10(-7) and 10(-2)M, whereas 131I-T4 delabelling was markedly stimulated at the same drug concentrations.	Methimazole	47-50	myeloperoxidase	Homo sapiens	71-74	
164965-3	1975	Methimazole, which inhibits myeloperoxidase, was also without effect.	Methimazole	0-11	myeloperoxidase	Homo sapiens	28-43	
4629909-4	1973	Methimazole stimulates deiodination by MPO and H(2)O(2) but inhibits this reaction when MPO is replaced by lactoperoxidase or horseradish peroxidase.Intact human leukocytes, in the resting state, degrade T(4) and T(3) slowly: degradation, however, is increased markedly during phagocytosis of preopsonized particles.	Methimazole	0-11	myeloperoxidase	Homo sapiens	39-42	
4629909-4	1973	Methimazole stimulates deiodination by MPO and H(2)O(2) but inhibits this reaction when MPO is replaced by lactoperoxidase or horseradish peroxidase.Intact human leukocytes, in the resting state, degrade T(4) and T(3) slowly: degradation, however, is increased markedly during phagocytosis of preopsonized particles.	Methimazole	0-11	myeloperoxidase	Homo sapiens	88-91	
4629909-13	1973	Methimazole inhibits the formation of iodinated origin material by both normal and MPO-deficient leukocytes.	Methimazole	0-11	myeloperoxidase	Homo sapiens	83-86