PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29353278-5 2018 hOAT1 and hOAT3 transported [14C]p-aminohippurate and [3H]estrone-3-sulfate (ES) with Michaelis-Menten constants of 29.8 +- 4.0 and 30.1 +- 9.0 micromol/L respectively. Einsteinium 77-79 solute carrier family 22 member 8 Homo sapiens 10-15 27812757-12 2016 If no other transporter markedly contributes to uptake or release of ES or cGMP, respectively, these data suggest that OAT3 and OAT2 may be involved in absorption, metabolism, and excretion of dantrolene and its metabolite 5-OH dantrolene. Einsteinium 69-71 solute carrier family 22 member 8 Homo sapiens 119-123 28630284-5 2017 With OAT3, a dose-dependent inhibition of [3H]ES uptake and a downward shift in [3H]ES equilibrium were observed, indicating that all four drugs bind to OAT3 and may possibly be translocated. Einsteinium 46-48 solute carrier family 22 member 8 Homo sapiens 5-9 28630284-5 2017 With OAT3, a dose-dependent inhibition of [3H]ES uptake and a downward shift in [3H]ES equilibrium were observed, indicating that all four drugs bind to OAT3 and may possibly be translocated. Einsteinium 84-86 solute carrier family 22 member 8 Homo sapiens 5-9 28630284-5 2017 With OAT3, a dose-dependent inhibition of [3H]ES uptake and a downward shift in [3H]ES equilibrium were observed, indicating that all four drugs bind to OAT3 and may possibly be translocated. Einsteinium 84-86 solute carrier family 22 member 8 Homo sapiens 153-157 27812757-10 2016 In counter-flow experiments on OAT3, dantrolene and 5-OH dantrolene decreased pre-equilibrated cellular [3H]estrone-3-sulfate (ES) content as did the transported substrates glutarate, furosemide, and bumetanide. Einsteinium 127-129 solute carrier family 22 member 8 Homo sapiens 31-35 25477469-5 2015 Melphalan had no significant inhibitory effect on any OAT, whereas chlorambucil reduced OAT1-, OAT3-, and OAT4-mediated uptake of PAH or ES down to 14.6%, 16.3%, and 66.0% of control, respectively. Einsteinium 137-139 solute carrier family 22 member 8 Homo sapiens 95-99 25477469-6 2015 Bendamustine inhibited only OAT3-mediated ES uptake, which was reduced down to 14.3% of control cells, suggesting that it interacts exclusively with OAT3. Einsteinium 42-44 solute carrier family 22 member 8 Homo sapiens 28-32