PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22387464-6 2012 In contrast to their similar in vitro properties, transcriptional activation of oct4 by these distinct dTALEs varied up to 25-fold. dtales 103-109 POU class 5 homeobox 1 Homo sapiens 80-84 22387464-7 2012 While dTALEs efficiently upregulated transcription of the active oct4 promoter in embryonic stem cells (ESCs) they failed to activate the silenced oct4 promoter in ESC-derived neural stem cells (NSCs), indicating that as for endogenous transcription factors also dTALE activity is limited by repressive epigenetic mechanisms. dtales 6-12 POU class 5 homeobox 1 Homo sapiens 65-69 22387464-9 2012 Notably, demethylation of the oct4 promoter occurred only if chemical inhibitors and dTALEs were applied together but not upon treatment with inhibitors or dTALEs only. dtales 85-91 POU class 5 homeobox 1 Homo sapiens 30-34 22387464-9 2012 Notably, demethylation of the oct4 promoter occurred only if chemical inhibitors and dTALEs were applied together but not upon treatment with inhibitors or dTALEs only. dtales 156-162 POU class 5 homeobox 1 Homo sapiens 30-34