PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9048568-11 1997 Both native and ASA-treated PGHS-2 produced only the R stereoisomer of 11- and 15-HETE, demonstrating that the lipoxygenase stereochemistry was not changed by ASA. Hydroxyeicosatetraenoic Acids 81-86 prostaglandin-endoperoxide synthase 2 Homo sapiens 28-34 20966635-2 2010 Although cyclooxygenase-2 (COX- 2) and its product, prostaglandin E(2) (PGE((2))), have been associated with UVB-induced signaling to MMP expression, very little are known about the roles of lipoxygenases and their products, especially leukotriene B((4)) (LTB((4))) and 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), in MMP-1 expression in skin keratinocytes. Hydroxyeicosatetraenoic Acids 312-316 prostaglandin-endoperoxide synthase 2 Homo sapiens 27-33 9016346-4 1997 The time courses of turnover-dependent inactivation were similar for reactions catalyzed by PGHS-2 and ASA-PGHS-2, whereas the PGHS-2(S516M) showed a decrease in both the initial rate of 15-HETE production and rate of enzyme inactivation. Hydroxyeicosatetraenoic Acids 190-194 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-98 9016346-4 1997 The time courses of turnover-dependent inactivation were similar for reactions catalyzed by PGHS-2 and ASA-PGHS-2, whereas the PGHS-2(S516M) showed a decrease in both the initial rate of 15-HETE production and rate of enzyme inactivation. Hydroxyeicosatetraenoic Acids 190-194 prostaglandin-endoperoxide synthase 2 Homo sapiens 103-113 17640979-8 2007 We found that HETEs enhanced IL-1-induced COX-2 mRNA levels in CMF as the result of increased p38, MK-2, and HuR activity, increasing message stability greater than that observed with IL-1 alone. Hydroxyeicosatetraenoic Acids 14-19 prostaglandin-endoperoxide synthase 2 Homo sapiens 42-47