PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22868770-4 2012 Owing to the impact of crystallization conditions on the conformation of protein kinases (and in particular p38alpha), the structures of complexes of p38alpha with SB-203580, SCIO-469 and VX-745 have also been determined to enable in-depth comparison of ligand-induced protein conformations. Antimony 164-166 mitogen-activated protein kinase 14 Homo sapiens 150-158 23602051-8 2013 The expression level of MLCK and phosphorylation of MLC of breast cancer cells was reduced when the cells were treated by ATPR with 48 h, the phosphorylation of ERK, JNK and p38 in breast cancer also reduced when cells were treated by ATPR with 2 h. In addition, ML-7 (50 mumol/l) could inhibit the phosphorylation of p38 and SB (50 mumol/l) could inhibit the expression of MLCK and phosphorylation of MLC. Antimony 326-328 mitogen-activated protein kinase 14 Homo sapiens 174-177 12637577-2 2003 Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha (SBR-p38alpha) that fails to bind to SB 203580. Antimony 205-207 mitogen-activated protein kinase 14 Homo sapiens 139-142 17996717-1 2008 The binding reactions of the inhibitor drugs, SB 203580, SKF 86002, and p38 INH.1 to the isoforms 1 and 2 splice variants of p38alpha MAP kinase and their C162S mutants, as determined from ITC measurements from 25 to 35 degrees C, are totally enthalpically driven with binding constants ranging from 10(7)M(-1) for SKF 86002 and SB 203580 to 10(9)M(-1) for p38 INH.1. Antimony 46-48 mitogen-activated protein kinase 14 Homo sapiens 125-133 17996717-1 2008 The binding reactions of the inhibitor drugs, SB 203580, SKF 86002, and p38 INH.1 to the isoforms 1 and 2 splice variants of p38alpha MAP kinase and their C162S mutants, as determined from ITC measurements from 25 to 35 degrees C, are totally enthalpically driven with binding constants ranging from 10(7)M(-1) for SKF 86002 and SB 203580 to 10(9)M(-1) for p38 INH.1. Antimony 46-48 mitogen-activated protein kinase 14 Homo sapiens 125-128 17996717-4 2008 Two transitions, however, were observed for the isoform-drug complexes of SB 203580 and p38 INH.1 and were attributed to decoupled unfolding of the N- and C-terminal domains of the kinase. Antimony 74-76 mitogen-activated protein kinase 14 Homo sapiens 88-91 22002864-3 2012 In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha. Antimony 57-59 mitogen-activated protein kinase 14 Homo sapiens 43-46 22002864-4 2012 In addition, pretreatment of cells with TNF-alpha increased basal and H(2)O(2)-stimulated p38 MAPK and apoptosis of cardiac myocytes, and p38 MAPK-associated apoptosis of cardiac myocytes induced by TNF-alpha was blocked by inhibition of p38 MAPK with SB. Antimony 252-254 mitogen-activated protein kinase 14 Homo sapiens 138-141 22002864-4 2012 In addition, pretreatment of cells with TNF-alpha increased basal and H(2)O(2)-stimulated p38 MAPK and apoptosis of cardiac myocytes, and p38 MAPK-associated apoptosis of cardiac myocytes induced by TNF-alpha was blocked by inhibition of p38 MAPK with SB. Antimony 252-254 mitogen-activated protein kinase 14 Homo sapiens 138-141 16052670-10 2005 Addition of the SB compound during the incubation reduced the apoptotic rate to about 7.6% for all the treatment groups, suggesting that P38 activation is essential for cisplatin- and DTT-induced apoptosis in Eca109 cells. Antimony 16-18 mitogen-activated protein kinase 14 Homo sapiens 137-140 15946254-6 2005 The LTA-induced p38 MAPK activation was inhibited by genistein, tyrphostin AG126, wortmannin, LY 294002, and SB 203580. Antimony 109-111 mitogen-activated protein kinase 14 Homo sapiens 16-19 15723092-6 2005 Inhibition of Raf1, mitogen-activated protein kinase kinase (MAPKK/MEK) and p38 MAPK with, respectively, GW 5074, PD 98059 and SB 203580 and downregulation of protein kinase C (PKC) with phorbol-12,13-dibutyrate (100 nM for 24 h) prevented inhibition of NHE activity by IFN-gamma (0.5 and 24 h exposure). Antimony 127-129 mitogen-activated protein kinase 14 Homo sapiens 76-79 12637577-2 2003 Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha (SBR-p38alpha) that fails to bind to SB 203580. Antimony 249-251 mitogen-activated protein kinase 14 Homo sapiens 139-142 12176102-4 2002 Lipoteichoic acid-induced increase in p38 MAPK activity was inhibited by Go 6976, Ro 31-8220, genistein and SB 203580. Antimony 108-110 mitogen-activated protein kinase 14 Homo sapiens 38-41 10321729-1 1999 The inhibition of SAPK2a/p38 (a mitogen activated protein (MAP) kinase family member) by SB 203580 depends on the presence of threonine at residue 106. Antimony 89-91 mitogen-activated protein kinase 14 Homo sapiens 18-24 10321729-1 1999 The inhibition of SAPK2a/p38 (a mitogen activated protein (MAP) kinase family member) by SB 203580 depends on the presence of threonine at residue 106. Antimony 89-91 mitogen-activated protein kinase 14 Homo sapiens 25-28 34571074-3 2021 Moreover, the p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal-related kinase (ERK) pathways were activated following Sb exposure. Antimony 142-144 mitogen-activated protein kinase 14 Homo sapiens 14-50 34571074-3 2021 Moreover, the p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal-related kinase (ERK) pathways were activated following Sb exposure. Antimony 142-144 mitogen-activated protein kinase 14 Homo sapiens 52-60 34571074-4 2021 Inhibition of p38 MAPK reduced Sb-induced iNOS and GFAP upregulation, while inhibiting ERK reduced GFAP expression only, in Sb-exposed C6 cells. Antimony 31-33 mitogen-activated protein kinase 14 Homo sapiens 14-22 34571074-6 2021 Furthermore, inhibiting both p38 MAPK and ERK effectively alleviated CREB phosphorylation in Sb-exposed C6 cells. Antimony 93-95 mitogen-activated protein kinase 14 Homo sapiens 29-37