PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18490434-6	2008	Rifampin increased ERBTs in CYP3A5(*)1 carriers (4.68 versus 2.60%, P = 0.0008) and noncarriers (3.55 versus 2.11%, P = 0.0017), whereas dexamethasone increased ERBTs only in CYP3A5(*)1 noncarriers (3.03 versus 2.14%, P = 0.031).	Rifampin	0-8	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	28-34	
30170758-3	2018	Rifampin induces UGT1A9, UGT2B7, CYP3A4, and CYP3A5.	Rifampin	0-8	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	45-51	
20818746-7	2010	Upon activation of PXR by rifampicin, the messenger RNA levels of CYP3A4, CYP3A5, and CYP3A7 increased 49- to 213-fold versus HepG2 cells.	Rifampin	26-36	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	74-80	
18490434-6	2008	Rifampin increased ERBTs in CYP3A5(*)1 carriers (4.68 versus 2.60%, P = 0.0008) and noncarriers (3.55 versus 2.11%, P = 0.0017), whereas dexamethasone increased ERBTs only in CYP3A5(*)1 noncarriers (3.03 versus 2.14%, P = 0.031).	Rifampin	0-8	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	175-181	
12673034-3	2003	In this study, we demonstrated the inductive effects of phenobarbital, rifampicin, carbamazepine, phenytoin, prednisolone, ciclosporin and clotrimazole on CYP3A4, CYP3A5 and CYP3A7 mRNA expression, and established the relationship between the expression of human glucocorticoid receptor alpha (hGR) mRNA and the induction of CYP3A4 mRNA in cultured HepG2 cells by reverse transcription polymerase chain reaction (RT-PCR).	Rifampin	71-81	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	163-169	
17978482-8	2007	On the other hand, CYP3A4, CYP3A5, and CYP3A7 mRNA expression levels in HepG2 cells were increased from 2- to 3-fold by treatment with DEX and RIF.	Rifampin	143-146	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	27-33	
15681896-5	2004	CYP3A4 and CYP3A5 mRNA levels after exposure to 50 microM rifampicin (positive control for CYP3As) were significantly increased by 5.8 (p<0.01) and 2.0 times (p<0.01), respectively, compared with untreated controls.	Rifampin	58-68	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	11-17	
15309450-6	2004	In addition, carotenoid- or retinol-mediated gene expression of PXR-responsive genes like CYP3A4/CYP3A7, CYP3A5, MDR-1 and MRP-2 has been determined in HepG2 cells by RT-PCR with up-regulative properties of beta-carotene or retinol being comparable to or even higher than that of rifampicin.	Rifampin	280-290	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	105-111	
15252010-3	2004	We report the induction of CYP3A5 mRNA in 13 of 16 hepatocyte preparations exposed to rifampin.	Rifampin	86-94	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	27-33	
15319341-8	2004	Real-time polymerase chain reaction and Western blot analysis revealed significantly increased CYP3A4 mRNA and protein levels in hepatocytes treated with 10 microM rifampicin compared with untreated cells, but only modest effects of rifampicin on CYP3A5 induction.	Rifampin	164-174	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	247-253	
12843640-11	2003	Exposure to rifampicin also reduced CYP3A5 and CYP3A7 mRNA levels for donors 1 and 3 at 0.5% and 2.5% DMSO.	Rifampin	12-22	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	36-42	
12673034-7	2003	Treatment with phenytoin, rifampicin, carbamazepine and ciclosporin induced approximately 2-fold increases in the expression of CYP3A5 mRNA, although prednisolone, phenytoin and clotrimazole had no effect.	Rifampin	26-36	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	128-134	
12504802-6	2003	Up-regulation of endogenous CYP3A4 and CYP3A5 mRNA was obtained by gamma-tocotrienol, the most potent activator of PXR, with the same efficacy as with rifampicin.	Rifampin	151-161	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	39-45	
9157990-7	1997	In one human hepatocyte culture that contained the polymorphically expressed CYP3A5 in addition to the more widely expressed CYP3A4, only CYP3A4 was induced by cyclophosphamide, ifosfamide, and rifampin.	Rifampin	194-202	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	77-83	
12040753-6	2002	The levels of CYP1A1, CYP2B6, CYP2C8, CYP3A4, CYP3A5, ADH3, and ABCG1 mRNA in human hepatocytes increased after exposure to rifampicin.	Rifampin	124-134	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	46-52	
11744607-11	2002	The mRNA of CYP2E1, CYP3A5, CYP3A7, CYP4A11, and CYP4B1 genes were variably expressed at baseline and following rifampin treatment.	Rifampin	112-120	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	20-26	
33963620-2	2021	Isavuconazole is metabolized by CYP3A4 and CYP3A5 and it has been shown that the CYP3A inducer rifampin reduces isavuconazole exposure.	Rifampin	95-103	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	43-49