PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11745918-3	2001	The rabbit isoform CYP3A6 and the human isoform CYP3A4 have similar P-450 predominance and substrate specificity and are both induced by rifampin.	Rifampin	137-145	cytochrome P450 3A6	Oryctolagus cuniculus	19-25	
11745918-8	2001	Rifampin increased CYP3A6 activity by 2- to 3-fold in hepatic microsomes compared to vehicle.	Rifampin	0-8	cytochrome P450 3A6	Oryctolagus cuniculus	19-25	
11745918-5	2001	We determined the in vivo and ex vivo CYP3A6 induction by 4 days of treatment with rifabutin (100 mg/kg), rifampin (100 mg/kg), or vehicle (DMSO) in the rabbit.	Rifampin	106-114	cytochrome P450 3A6	Oryctolagus cuniculus	38-44	
11491386-9	2001	Since CYP3A6 is mainly induced by rifampicin in rabbit-cultured hepatocytes, the data suggest that this isoform is involved in the biotransformation of MDEA to 3OH-MDEA.	Rifampin	34-44	cytochrome P450 3A6	Oryctolagus cuniculus	6-12	
9825726-1	1998	Cultured rabbit hepatocytes were used to compare the relative activities of cytokines to inhibit the constitutive or rifampicin (RIF)-induced expression of the cytochrome P450 3A6 gene (CYP3A6).	Rifampin	117-127	cytochrome P450 3A6	Oryctolagus cuniculus	160-179	
9825726-1	1998	Cultured rabbit hepatocytes were used to compare the relative activities of cytokines to inhibit the constitutive or rifampicin (RIF)-induced expression of the cytochrome P450 3A6 gene (CYP3A6).	Rifampin	117-127	cytochrome P450 3A6	Oryctolagus cuniculus	186-192	
9825726-1	1998	Cultured rabbit hepatocytes were used to compare the relative activities of cytokines to inhibit the constitutive or rifampicin (RIF)-induced expression of the cytochrome P450 3A6 gene (CYP3A6).	Rifampin	129-132	cytochrome P450 3A6	Oryctolagus cuniculus	160-179	
9825726-1	1998	Cultured rabbit hepatocytes were used to compare the relative activities of cytokines to inhibit the constitutive or rifampicin (RIF)-induced expression of the cytochrome P450 3A6 gene (CYP3A6).	Rifampin	129-132	cytochrome P450 3A6	Oryctolagus cuniculus	186-192	
8844805-8	1995	In addition, Rifampicin-induced rabbit liver microsomes which are enriched for CYP3A6, show enhanced activation of MeIQ in the presence of alpha-napthoflavone.	Rifampin	13-23	cytochrome P450 3A6	Oryctolagus cuniculus	79-85	
2015817-6	1991	Onset of CYP3A6 gene expression occurred at day 30 of gestation and both transcription and mRNA accumulation were transplacentally inducible by rifampicin only shortly before birth, i.e. after treatment of the females between days 28 and 30 of gestation.	Rifampin	144-154	cytochrome P450 3A6	Oryctolagus cuniculus	9-15	
2015817-8	1991	CYP3A6 gene expression was also induced by rifampicin in 1-week-old and 2-week-old animals.	Rifampin	43-53	cytochrome P450 3A6	Oryctolagus cuniculus	0-6	
2015817-15	1991	It is concluded that (a) the onset of CYP3A6 gene expression in the fetus occurs at day 30 of gestation, (b) expression of this gene may be induced transplacentally by rifampicin, (c) CYP1A1, CYP1A2 and CYP3A6 gene expression is sharply activated at weaning, and (d) thyroid hormones appear not to be responsible for the pattern of developmental expression of these genes in the rabbit.	Rifampin	168-178	cytochrome P450 3A6	Oryctolagus cuniculus	38-44	
2015817-15	1991	It is concluded that (a) the onset of CYP3A6 gene expression in the fetus occurs at day 30 of gestation, (b) expression of this gene may be induced transplacentally by rifampicin, (c) CYP1A1, CYP1A2 and CYP3A6 gene expression is sharply activated at weaning, and (d) thyroid hormones appear not to be responsible for the pattern of developmental expression of these genes in the rabbit.	Rifampin	168-178	cytochrome P450 3A6	Oryctolagus cuniculus	203-209	
2777787-3	1989	In this report, we demonstrate that in immature rabbits, rifampicin activates the transcription of the Cyp3A6 gene which encodes P450IIIA6 (cytochrome P-450 3c).	Rifampin	57-67	cytochrome P450 3A6	Oryctolagus cuniculus	103-109	
2777787-3	1989	In this report, we demonstrate that in immature rabbits, rifampicin activates the transcription of the Cyp3A6 gene which encodes P450IIIA6 (cytochrome P-450 3c).	Rifampin	57-67	cytochrome P450 3A6	Oryctolagus cuniculus	140-159	
3182866-5	1988	The antibiotic rifampicin induces cytochrome P-450 3c in rabbit liver microsomes, and the benzo(a)pyrene hydroxylase, estradiol 2-hydroxylase, and progesterone 6 beta-hydroxylase activities of these microsomes are stimulated by alpha-naphthoflavone.	Rifampin	15-25	cytochrome P450 3A6	Oryctolagus cuniculus	34-53	
3367901-1	1988	Rifampicin induces cytochrome P-450 3c, progesterone 16 alpha- and 6 beta-hydroxylation, 17 beta-estradiol 2-hydroxylation, benzo[a] pyrene hydroxylation, and erythromycin N-demethylation in rabbit liver microsomes.	Rifampin	0-10	cytochrome P450 3A6	Oryctolagus cuniculus	19-38