PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25835148-0 2015 Expression of hepatic cytochrome P450s and UDP-glucuronosyltransferases in PXR and CAR double humanized mice treated with rifampicin. Rifampin 122-132 nuclear receptor subfamily 1, group I, member 2 Mus musculus 75-78 29095659-0 2018 Indirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice. Rifampin 92-102 nuclear receptor subfamily 1, group I, member 2 Mus musculus 23-42 29095659-6 2018 In addition, high-dose RIF stimulated nuclear accumulation of mPXR in the mouse liver, and geldanamycin and okadaic acid attenuated the induction of Cyp3a11 and other PXR-target genes in primary hepatocytes, suggesting that high-dose RIF triggers nuclear translocation of mPXR. Rifampin 23-26 nuclear receptor subfamily 1, group I, member 2 Mus musculus 62-66 29095659-6 2018 In addition, high-dose RIF stimulated nuclear accumulation of mPXR in the mouse liver, and geldanamycin and okadaic acid attenuated the induction of Cyp3a11 and other PXR-target genes in primary hepatocytes, suggesting that high-dose RIF triggers nuclear translocation of mPXR. Rifampin 23-26 nuclear receptor subfamily 1, group I, member 2 Mus musculus 63-66 29095659-6 2018 In addition, high-dose RIF stimulated nuclear accumulation of mPXR in the mouse liver, and geldanamycin and okadaic acid attenuated the induction of Cyp3a11 and other PXR-target genes in primary hepatocytes, suggesting that high-dose RIF triggers nuclear translocation of mPXR. Rifampin 23-26 nuclear receptor subfamily 1, group I, member 2 Mus musculus 272-276 27806127-10 2016 Instead, hepatic PXR was rapidly activated in rifampicin-treated mice. Rifampin 46-56 nuclear receptor subfamily 1, group I, member 2 Mus musculus 17-20 29358328-7 2018 Of note, M. tuberculosis infection and rifampicin exposure synergistically modulated macrophage drug-efflux transporters in vitro We also found that the xenobiotic nuclear receptor pregnane X receptor (PXR) modulates macrophage drug-efflux transporter expression and activity, which compromised the anti-TB efficacy of rifampicin. Rifampin 39-49 nuclear receptor subfamily 1, group I, member 2 Mus musculus 202-205 29358328-7 2018 Of note, M. tuberculosis infection and rifampicin exposure synergistically modulated macrophage drug-efflux transporters in vitro We also found that the xenobiotic nuclear receptor pregnane X receptor (PXR) modulates macrophage drug-efflux transporter expression and activity, which compromised the anti-TB efficacy of rifampicin. Rifampin 319-329 nuclear receptor subfamily 1, group I, member 2 Mus musculus 202-205 29358328-8 2018 We further validated this finding in a TB mouse model in which use of the PXR antagonist ketoconazole rescued rifampicin anti-TB activity. Rifampin 110-120 nuclear receptor subfamily 1, group I, member 2 Mus musculus 74-77 29358328-9 2018 We conclude that PXR activation in macrophages compromises the efficacy of the anti-TB drug rifampicin. Rifampin 92-102 nuclear receptor subfamily 1, group I, member 2 Mus musculus 17-20 28345929-6 2017 As an assessment of CYP3A4 induction, following rifampin pretreatment to PXR-CAR-3A4/3A7Hep/Int mice, an 8% decrease in vandetanib mean AUC was observed; 39-52% reduction in AUC were observed for dasatinib, ibrutinib, regorafenib, and sorafenib compared to vehicle treated mice. Rifampin 48-56 nuclear receptor subfamily 1, group I, member 2 Mus musculus 73-76 25749104-5 2015 We hypothesized that genes induced by SXR in chondrocytes have a protective effect on articular cartilage and identified Fam20a (family with sequence similarity 20a) as an SXR-dependent gene induced by the known SXR ligands, rifampicin and vitamin K2. Rifampin 225-235 nuclear receptor subfamily 1, group I, member 2 Mus musculus 172-175 25749104-5 2015 We hypothesized that genes induced by SXR in chondrocytes have a protective effect on articular cartilage and identified Fam20a (family with sequence similarity 20a) as an SXR-dependent gene induced by the known SXR ligands, rifampicin and vitamin K2. Rifampin 225-235 nuclear receptor subfamily 1, group I, member 2 Mus musculus 38-41 25749104-5 2015 We hypothesized that genes induced by SXR in chondrocytes have a protective effect on articular cartilage and identified Fam20a (family with sequence similarity 20a) as an SXR-dependent gene induced by the known SXR ligands, rifampicin and vitamin K2. Rifampin 225-235 nuclear receptor subfamily 1, group I, member 2 Mus musculus 172-175 25341566-4 2014 Here, we showed that resveratrol (RES), a natural polyphenolic compound could significantly suppress the rifampicin-induced PXR transactivation of the CYP3A4 promoter. Rifampin 105-115 nuclear receptor subfamily 1, group I, member 2 Mus musculus 124-127 22253426-8 2012 Glucocorticoids, including dexamethasone, cortisol, corticosterone, and cortisone all induced the expression of CYP3A7 mRNA, whereas rifampicin, an activator of PXR and an inducer of CYP3A4 in adult liver, had no effect on CYP3A7 expression. Rifampin 133-143 nuclear receptor subfamily 1, group I, member 2 Mus musculus 161-164 22687401-3 2012 The induction of CALUX in HPL-A3 by hPXR activators, including rifampicin, occurred in time- and concentration-dependent fashions, whereas no such induction was observed using rat/mouse PXR activators, such as pregnenolone-16alpha-carbonitrile and dexamethasone. Rifampin 63-73 nuclear receptor subfamily 1, group I, member 2 Mus musculus 37-40 18799805-9 2008 By using TgCYP3A4/hPXR mice, human PXR-CYP3A4-mediated rifampicin-protease inhibitor interactions were recapitulated, as the metabolic stability of amprenavir, nelfinavir, and saquinavir decreased 52, 53, and 99%, respectively, in the liver microsomes of TgCYP3A4/hPXR mice pretreated with rifampicin. Rifampin 55-65 nuclear receptor subfamily 1, group I, member 2 Mus musculus 19-22 21205914-0 2011 Pharmacokinetic-pharmacodynamic modeling of rifampicin-mediated Cyp3a11 induction in steroid and xenobiotic X receptor humanized mice. Rifampin 44-54 nuclear receptor subfamily 1, group I, member 2 Mus musculus 85-118 21205914-2 2011 Rifampicin was administered to steroid and xenobiotic X receptor (SXR) humanized mice at 10 mg/kg p.o. Rifampin 0-10 nuclear receptor subfamily 1, group I, member 2 Mus musculus 31-64 21205914-2 2011 Rifampicin was administered to steroid and xenobiotic X receptor (SXR) humanized mice at 10 mg/kg p.o. Rifampin 0-10 nuclear receptor subfamily 1, group I, member 2 Mus musculus 66-69 20054495-9 2009 In addition, rifampicin increased physical interaction between pregnane X receptor, a receptor for rifampicin, and NF-kappaB p65, suggesting pregnane X receptor interferes with NF-kappaB binding to DNA. Rifampin 13-23 nuclear receptor subfamily 1, group I, member 2 Mus musculus 63-82 20054495-9 2009 In addition, rifampicin increased physical interaction between pregnane X receptor, a receptor for rifampicin, and NF-kappaB p65, suggesting pregnane X receptor interferes with NF-kappaB binding to DNA. Rifampin 13-23 nuclear receptor subfamily 1, group I, member 2 Mus musculus 141-160 20054495-9 2009 In addition, rifampicin increased physical interaction between pregnane X receptor, a receptor for rifampicin, and NF-kappaB p65, suggesting pregnane X receptor interferes with NF-kappaB binding to DNA. Rifampin 99-109 nuclear receptor subfamily 1, group I, member 2 Mus musculus 63-82 20054495-9 2009 In addition, rifampicin increased physical interaction between pregnane X receptor, a receptor for rifampicin, and NF-kappaB p65, suggesting pregnane X receptor interferes with NF-kappaB binding to DNA. Rifampin 99-109 nuclear receptor subfamily 1, group I, member 2 Mus musculus 141-160 18765524-10 2008 In mice harboring SKOV-3 xenografts, rifampicin (PXR agonist) induces cell proliferation and tumor growth. Rifampin 37-47 nuclear receptor subfamily 1, group I, member 2 Mus musculus 49-52 17962516-8 2008 In addition to pregnenolone 16alpha-carbonitrile, several clinically relevant PXR ligands (rifampicin and dexamethasone) all increased ATRA metabolism both in vitro and in vivo, which was PXR-dependent, and up-regulation of Cyp3a was the major contributor. Rifampin 91-101 nuclear receptor subfamily 1, group I, member 2 Mus musculus 78-81 17962516-8 2008 In addition to pregnenolone 16alpha-carbonitrile, several clinically relevant PXR ligands (rifampicin and dexamethasone) all increased ATRA metabolism both in vitro and in vivo, which was PXR-dependent, and up-regulation of Cyp3a was the major contributor. Rifampin 91-101 nuclear receptor subfamily 1, group I, member 2 Mus musculus 188-191 17093002-5 2007 Treatment of PXR-humanized mice with the PXR ligands mimicked the human response, since both hepatic and intestinal CYP3As were strongly induced by rifampicin, a human-specific PXR ligand, but not by pregnenolone 16alpha-carbonitrile, a rodent-specific PXR ligand. Rifampin 148-158 nuclear receptor subfamily 1, group I, member 2 Mus musculus 13-16 17093002-5 2007 Treatment of PXR-humanized mice with the PXR ligands mimicked the human response, since both hepatic and intestinal CYP3As were strongly induced by rifampicin, a human-specific PXR ligand, but not by pregnenolone 16alpha-carbonitrile, a rodent-specific PXR ligand. Rifampin 148-158 nuclear receptor subfamily 1, group I, member 2 Mus musculus 41-44 17093002-6 2007 In rifampicin-pretreated PXR-humanized mice, an approximately 60% decrease was observed for both the maximal midazolam serum concentration (C(max)) and the area under the concentration-time curve, as a result of a 3-fold increase in midazolam 1"-hydroxylation. Rifampin 3-13 nuclear receptor subfamily 1, group I, member 2 Mus musculus 25-28 15183191-6 2004 LPS also represses the upregulation of CYP3A11 mRNA levels and erythromycin N-demethylase (ERND) catalytic activity in mice pretreated with PXR ligands dexamethasone, rifampicin, mifepristone, and phenobarbital. Rifampin 167-177 nuclear receptor subfamily 1, group I, member 2 Mus musculus 140-143 17936928-10 2007 Since species differences exist in ligand specificity between human and mice, a PXR-humanized mouse (hPXR) was produced that responds to human PXR activators such as rifampicin but does not respond to the rodent activator pregnenalone 16alpha-carbonitrile. Rifampin 166-176 nuclear receptor subfamily 1, group I, member 2 Mus musculus 80-83 16973756-3 2007 Activation of PXR by genetic (transgene) or pharmacological (ligand, such as rifampicin) markedly increased plasma concentrations of corticosterone and aldosterone, the respective primary glucocorticoid and mineralocorticoid in rodents. Rifampin 77-87 nuclear receptor subfamily 1, group I, member 2 Mus musculus 14-17 12920130-7 2003 The known SXR activators rifampicin and hyperforin induced this panel of bone markers to an extent similar to vitamin K2. Rifampin 25-35 nuclear receptor subfamily 1, group I, member 2 Mus musculus 10-13 10628745-8 2000 For example, the macrolide antibiotic rifampicin, the antidiabetic drug troglitazone, and the hypocholesterolemic drug SR12813 are efficacious activators of the human and rabbit PXR but have little activity on the rat and mouse PXR. Rifampin 38-48 nuclear receptor subfamily 1, group I, member 2 Mus musculus 228-231 32492461-3 2020 The results showed that rifampin significantly increased transaminases, TBIL and TBA levels in serum, increased TG, TC content, HMGCR and CYP7A1 protein, CYP7A1, FGFR4, PXR, FAS and FXR mRNA expression, but decreased the level of SREBP-1c mRNA and induced severe steatohepatitis and hepatocyte necrosis in liver in mice. Rifampin 24-32 nuclear receptor subfamily 1, group I, member 2 Mus musculus 169-172 31998607-9 2020 Importantly, we observed significant upregulation of miR-18a-5p expression 6 h after treatment with the PXR ligand rifampicin, which indicates a putative mechanism underlying NR1I2 negative feed-back regulation in hepatic cells. Rifampin 115-125 nuclear receptor subfamily 1, group I, member 2 Mus musculus 104-107 12781341-9 2003 Co-injection of an antisense murine PXR construct with the CYP3A4-luc reduced both the dexamethasone- and rifampicin-induced responses, thus demonstrating that the murine PXR receptor can participate in the regulation of the human CYP3A4 promoter in mice. Rifampin 106-116 nuclear receptor subfamily 1, group I, member 2 Mus musculus 36-39 12781341-9 2003 Co-injection of an antisense murine PXR construct with the CYP3A4-luc reduced both the dexamethasone- and rifampicin-induced responses, thus demonstrating that the murine PXR receptor can participate in the regulation of the human CYP3A4 promoter in mice. Rifampin 106-116 nuclear receptor subfamily 1, group I, member 2 Mus musculus 171-174 10772631-0 2000 Rabbit pregnane X receptor is activated by rifampicin. Rifampin 43-53 nuclear receptor subfamily 1, group I, member 2 Mus musculus 7-26 32492461-6 2020 These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity. Rifampin 26-34 nuclear receptor subfamily 1, group I, member 2 Mus musculus 117-120 32492461-6 2020 These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity. Rifampin 26-34 nuclear receptor subfamily 1, group I, member 2 Mus musculus 242-245 32492461-6 2020 These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity. Rifampin 154-162 nuclear receptor subfamily 1, group I, member 2 Mus musculus 117-120 32492461-6 2020 These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity. Rifampin 154-162 nuclear receptor subfamily 1, group I, member 2 Mus musculus 242-245 31455676-11 2019 Expression of CYP3A4 and metabolism of triazolam, a typical CYP3A substrate, in the liver of CYP3A/PXR-humanized mice were enhanced in response to rifampicin, a typical human PXR activator. Rifampin 147-157 nuclear receptor subfamily 1, group I, member 2 Mus musculus 99-102