PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31676845-7 2019 We also demonstrated that matured Huh7s can be used for drug induction studies, where CYP3A4, CYP1A2, CYP2C9, and CYP2C19 inductions were achieved following rifampicin treatment. Rifampin 157-167 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 94-100 30762305-0 2019 Physiologically-Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam. Rifampin 149-159 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 49-55 31569378-4 2019 Validation of RGs was performed by an expression analysis of CYP3A4 and CYP1A2 on rifampicin and beta-naphthoflavone induction, respectively. Rifampin 82-92 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 72-78 28674261-5 2017 After 2 d exposure of hepatocyte spheroids to omeprazole, phenobarbital and rifampicin (typical inducers of CYP1A2, 2B6 and 3A4, respectively), CYP1A2, 2B6 and 3A4 mRNA expression levels were significantly increased. Rifampin 76-86 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 108-114 29469947-6 2018 The inducers omeprazole, phenobarbital and rifampicin increased the levels of CYP1A2, 2B6 and 3A4 mRNAs by 110-fold, 12.5-fold and 5.4-fold, respectively, at day 2, compared with control human hepatocytes. Rifampin 43-53 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 78-84 30347615-5 2018 METHODS: CYP1A2 and CYP3A4 were induced by omeprazole and rifampicin, respectively. Rifampin 58-68 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 9-15 29357810-5 2018 mRNA expression levels and enzyme activities of CYP1A2, CYP2B6, and CYP3A in HepaRG cells treated with prototypical inducers of each CYP isoform [omeprazole (OME) for CYP1A2, phenobarbital (PB) for CYP2B6, and rifampicin (RIF) for CYP3A] were evaluated. Rifampin 210-220 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 48-54 29357810-5 2018 mRNA expression levels and enzyme activities of CYP1A2, CYP2B6, and CYP3A in HepaRG cells treated with prototypical inducers of each CYP isoform [omeprazole (OME) for CYP1A2, phenobarbital (PB) for CYP2B6, and rifampicin (RIF) for CYP3A] were evaluated. Rifampin 222-225 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 48-54 26759747-2 2016 Rifampin is a widely used antimicrobial that has major interactions with several medications including warfarin due to its strong P-glycoprotein and liver enzyme inducer activity especially on CYP2C9, CYP3A4, CYP1A2 and CYP2C19. Rifampin 0-8 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 209-215 27917125-6 2016 After treatment with 20 muM rifampicin, mRNA increased 3- to 50-fold for all CYPs except CYP1A2 and 2D6 for HepaRG and 3D-PHH, 4-fold (CYP2B6) and 17-fold (CYP3A4) for 2D-PHH and four-fold (CYP3A4) for HepG2. Rifampin 28-38 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 89-95 25600204-2 2015 To evaluate time-dependent cytochrome P450 induction precisely, induction of CYP1A2, CYP2B6, and CYP3A4 mRNA was confirmed (>2-fold) by the treatment with omeprazole, phenobarbital, and rifampicin, respectively, for 24 or 48 h on day 3 from the start of culture. Rifampin 189-199 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 77-83 24752503-4 2014 Here, we present a simple suspension culture of aggregates of ES cell-derived hepatocytes that compared to conventional monolayer adherent culture significantly increases induction of CYP 1A2 by omeprazole and 3A4 by rifampicin. Rifampin 217-227 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 184-191 24316028-4 2014 There was a significant difference between CYP1A2 -739T/G and T/T genotypes when patients were treated with EFV-containing therapy combined with rifampicin-based TB treatment, but not when EFV-containing therapy was alone. Rifampin 145-155 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 43-49 24553381-5 2014 The results revealed that CYP1A2, CYP2B6, and CYP3A4 were induced (>2.0-fold) by omeprazole, phenobarbital, and rifampicin, respectively, in all the hepatocyte lots tested at enzyme activity level (23 lots) and mRNA level (8 lots). Rifampin 115-125 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 26-32 20583967-0 2010 A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with beta-naphthoflavone, phenobarbital and rifampicin. Rifampin 172-182 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 31-50 21930825-3 2011 Statistically significant induction of CYP1A2 (2.1-, 2.9-, and 2.2-fold), CYP2B6 (1.8-, 2.4-, and 4-fold), and CYP2C9 (1.3-, 1.8-, and 2.6-fold) was observed after NFV, RTV, or RIF treatment, respectively (as expected, CYP2D6 was not induced). Rifampin 177-180 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 39-45 21555507-6 2011 IL-6 suppressed induction of CYP1A2 enzyme activity by omeprazole and CYP3A4 enzyme activity by rifampicin but only at supraphysiological concentrations of IL-6. Rifampin 96-106 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 29-35 21111054-4 2011 METHODS: To evaluate the xenobiotic-mediated induction of hepatocellular gene expression, the prototypical inducers rifampicin (10 muM) and phenobarbital (1 mM) were used for CYP3A4, CITCO (1 muM) and artemisinin (50 muM) were used for CYP2B6, and 3-methylcholanthrene (1 muM) and omeprazole (50 muM) were utilized for induction of CYP1A2. Rifampin 116-126 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 332-338 20583967-3 2010 The concentration-dependent response and time-course for the induction of CYP1A2, CYP2B6 and CYP3A4 by inducing agents beta-naphthoflavone, phenobarbital and rifampicin, respectively were examined in two or more donors using multiple end-points (mRNA, enzyme activity and Western blot analysis). Rifampin 158-168 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 74-80 19686824-6 2009 The levels of CYP1A1, CYP1A2, CY2C9 and CYP3A4 mRNAs were not altered by Zolpidem, whereas model inducers dioxin and rifampicin significantly induced CYP1A and CYP2/3 gene expression, respectively. Rifampin 117-127 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 22-28 20019244-7 2010 Thus, CYP1A2, CYP2B6, and CYP3A4 were found to accurately respond to their respective prototypical inducers, i.e., omeprazole, phenobarbital, and rifampicin. Rifampin 146-156 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 6-12 19854261-5 2010 On the other hand, the model inducers, i.e. 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and rifampicin, significantly increased the levels of CYP1A2 and CYP3A4 mRNAs in all cultures. Rifampin 92-102 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 142-148 10673364-4 2000 Using an RT-competitive PCR (RT-cPCR) with beta-actin as the standard in this study, the constitutive and rifampicin (RFP)-induced expression of CYP3A4, CYP2C9, CYP2E1, and CYP1A2 mRNA in the HepG2 cells could be quantitatively and reproducibly determined. Rifampin 106-116 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 173-179 19881256-3 2009 Positive controls for CYP1A2 and CYP3A4 used beta-naphthoflavone (beta-NF) and rifampicin (Rif), respectively. Rifampin 79-89 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 22-28 19881256-3 2009 Positive controls for CYP1A2 and CYP3A4 used beta-naphthoflavone (beta-NF) and rifampicin (Rif), respectively. Rifampin 91-94 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 22-28 16324277-1 2005 OBJECTIVE: To study the combined effect of isoniazid and rifampicin on the activities of CYP1A2 and 3A4 in primary hepatocytes from healthy human adults. Rifampin 57-67 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 89-95 16324277-10 2005 The activity of CYP1A2 of groups with two kinds of different concentrations of isoniazid and rifampicin combined groups was (3.27 +/- 0.96), (3.97 +/- 0.25) mAU.min respectively, which had significant difference compared with that in the negative control group (P < 0.05). Rifampin 93-103 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 16-22 8843295-13 1996 A comparison of equal doses of rifampin and rifabutin administered to healthy volunteers for 2 weeks indicates that induction of CYP1A2, as measured by theophylline clearance, is significantly less following rifabutin treatment than it is following rifampin treatment. Rifampin 31-39 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 129-135 9141435-3 1997 In the absence of EGF, the accumulation of CYP3A4 and CYP1A2 messenger RNAs (mRNAs) in response to their respective inducers (rifampicin and dioxin) was dramatically decreased in subconfluent culture with respect to confluent cultures. Rifampin 126-136 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 54-60 9454825-7 1998 The observed changes in the activity and protein levels of CYP1A2 and CYP3A4 correlated with a reduction in the specific messenger RNA levels both in control, 3-methylcholanthrene-treated (for CYP1A2) and rifampicin-treated (for CYP3A4) hepatocytes, which thus suggested that HGF could down-regulate CYP expression at a pretranslational level. Rifampin 205-215 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 59-65 8843295-3 1996 This study, involving 12 adult male volunteers, compared the effects of 14-day courses of rifampin and rifabutin on clearance of theophylline, a substrate for the hepatic microsomal enzyme CYP1A2. Rifampin 90-98 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 189-195 7557864-6 1995 When cells were treated with the CYP inducer alone, large increases in the expression of CYP1A1 and CYP1A2 by beta-naphthoflavone and of CYP3A4 by rifampicin were observed at messenger RNA (mRNA) and protein levels, by ribonuclease protection and immunoblotting, respectively. Rifampin 147-157 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 100-106 7557864-10 1995 In cells preinduced with beta-naphthoflavone or rifampicin, the decay with time of the levels of the CYP1A2 or CYP3A4 proteins, after the removal of the inducer, was not affected by cytokines. Rifampin 48-58 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 101-107 7585637-5 1995 Pretreatment of the cells with 3-methylcholanthrene or rifampicin, inducers of CYP1A2 and CYP3A4, respectively, caused a significant increase in AFB1 metabolism. Rifampin 55-65 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 79-85