PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8127415-1	1993	We have developed a convenient method combining fast protein liquid chromatography (FPLC) with sensitive radioimmunoassay (RIA) for thyrotropin-releasing hormone (TRH) to separate and identify TRH and its metabolite histidyl-proline diketopiperazine (CHP) and applied this to study inactivation of TRH by blood extracts from patients with liver cirrhosis (LC) and acute edematous pancreatitis (AP).	histidyl-proline diketopiperazine	216-249	thyrotropin releasing hormone	Homo sapiens	132-161	
27529240-4	2016	Cyclo(His-Pro), a cyclic dipeptide derived from the hydrolytic removal of the amino-terminal pyroglutamic acid residue of the hypothalamic thyrotropin-releasing hormone, may be important in regulating the nature of the glial cell contribution.	histidyl-proline diketopiperazine	0-13	thyrotropin releasing hormone	Homo sapiens	139-168	
8127415-1	1993	We have developed a convenient method combining fast protein liquid chromatography (FPLC) with sensitive radioimmunoassay (RIA) for thyrotropin-releasing hormone (TRH) to separate and identify TRH and its metabolite histidyl-proline diketopiperazine (CHP) and applied this to study inactivation of TRH by blood extracts from patients with liver cirrhosis (LC) and acute edematous pancreatitis (AP).	histidyl-proline diketopiperazine	216-249	thyrotropin releasing hormone	Homo sapiens	163-166	
6401750-0	1983	Detection in human serum by radioimmunoassay of histidyl-proline diketopiperazine, a metabolite of thyrotropin-releasing hormone.	histidyl-proline diketopiperazine	48-81	thyrotropin releasing hormone	Homo sapiens	99-128	
8407917-3	1993	Incubation of TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor, with brain hypothalamic cytosols caused significant formation of His-Pro-Gly followed by the generation of histidyl-proline diketopiperazine (cyclo(His-Pro)), whereas TRH was not formed.	histidyl-proline diketopiperazine	166-199	thyrotropin releasing hormone	Homo sapiens	14-17	
8407917-3	1993	Incubation of TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor, with brain hypothalamic cytosols caused significant formation of His-Pro-Gly followed by the generation of histidyl-proline diketopiperazine (cyclo(His-Pro)), whereas TRH was not formed.	histidyl-proline diketopiperazine	166-199	thyrotropin releasing hormone	Homo sapiens	44-47	
8407917-3	1993	Incubation of TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor, with brain hypothalamic cytosols caused significant formation of His-Pro-Gly followed by the generation of histidyl-proline diketopiperazine (cyclo(His-Pro)), whereas TRH was not formed.	histidyl-proline diketopiperazine	166-199	thyrotropin releasing hormone	Homo sapiens	44-47	
3092130-3	1986	Histidyl proline diketopiperazine (HisPro-DKP), a possible metabolite of TRH, was significantly elevated per protein content in ALS.	histidyl-proline diketopiperazine	0-33	thyrotropin releasing hormone	Homo sapiens	73-76	
3092130-3	1986	Histidyl proline diketopiperazine (HisPro-DKP), a possible metabolite of TRH, was significantly elevated per protein content in ALS.	histidyl-proline diketopiperazine	35-45	thyrotropin releasing hormone	Homo sapiens	73-76	
7411481-2	1980	1 degree Histidyl-proline-diketopiperazine (DKP), a major degradation product of TRH in hypothalamus and pituitary, inhibited prolactin secretion from incubated hemipituitaries (Fig.	histidyl-proline diketopiperazine	44-47	thyrotropin releasing hormone	Homo sapiens	81-84	
107159-11	1979	We hypothesize that pituitary hormones may stimulate the production of (cyclo)-His-Pro by inhibiting alternate routes of TRH metabolism.	histidyl-proline diketopiperazine	71-86	thyrotropin releasing hormone	Homo sapiens	121-124