PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17477920-2	2007	We have studied the effect of the lycopene, quercetin and tyrosol natural antioxidants on the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 macrophages stimulated by gliadin in association with IFN-gamma.	Lycopene	34-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	137-153	
28386381-8	2017	RESULTS: In cells treated with lycopene and LPS, the mRNA expression of TNF-alpha, IL-1beta, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P < 0.05).	Lycopene	31-39	prostaglandin-endoperoxide synthase 2	Homo sapiens	109-114	
31491956-0	2019	Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells.	Lycopene	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-99	
31491956-5	2019	This study aims to investigate whether lycopene inhibits proliferation and induces apoptosis in gastric cancer AGS cells by suppressing the EGFR/Ras/MAPK and NF-kappaB-COX-2 signaling axis.	Lycopene	39-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	168-173	
31491956-7	2019	Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression.	Lycopene	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	285-290	
31491956-8	2019	These results show that lycopene-induced apoptosis and inhibition of proliferation occur via inhibition of ROS-activated EGFR/Ras/ERK and p38 MAPK pathways and NF-kappaB-mediated COX-2 gene expression in AGS cells.	Lycopene	24-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	179-184	
29731858-4	2018	The effects of lycopene and beta-carotene on the expression of PPARgamma, p21WAF1/CIP1, cyclin D1 and cyclooxygenase-2 (COX-2) were analyzed by western blotting.	Lycopene	15-23	prostaglandin-endoperoxide synthase 2	Homo sapiens	102-118	
29731858-7	2018	Lycopene and beta-carotene treatments upregulated the expression of PPARgamma and p21WAF1/CIP1, and downregulated the expression of cyclin D1 and COX-2.	Lycopene	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	146-151	
29731858-8	2018	These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression.	Lycopene	139-147	prostaglandin-endoperoxide synthase 2	Homo sapiens	254-259	
28386381-11	2017	CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.	Lycopene	13-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	149-154