PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32962341-0 2020 Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1alpha-Induced PPARalpha/PPARgamma/FXR/LXR System. Lycopene 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 110-119 30512227-9 2019 CONCLUSION: These results show that lycopene isomers exert similar biological functions in adipocytes, linked to their ability to transactivate PPARgamma. Lycopene 36-44 peroxisome proliferator activated receptor gamma Homo sapiens 144-153 30889234-8 2019 Also, lycopene treatment increased the expression of RXR-alpha, RXR-beta, and PPARgamma, important biomarkers of liver regeneration. Lycopene 6-14 peroxisome proliferator activated receptor gamma Homo sapiens 78-87 25004019-0 2014 Retraction: Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages. Lycopene 12-20 peroxisome proliferator activated receptor gamma Homo sapiens 83-92 29731858-2 2018 In the present study, the role of peroxisome proliferator-activated receptor gamma (PPARgamma) in the effect of lycopene and beta-carotene on the viability of EC109 human esophageal squamous carcinoma cells was investigated. Lycopene 112-120 peroxisome proliferator activated receptor gamma Homo sapiens 34-82 29731858-2 2018 In the present study, the role of peroxisome proliferator-activated receptor gamma (PPARgamma) in the effect of lycopene and beta-carotene on the viability of EC109 human esophageal squamous carcinoma cells was investigated. Lycopene 112-120 peroxisome proliferator activated receptor gamma Homo sapiens 84-93 29731858-7 2018 Lycopene and beta-carotene treatments upregulated the expression of PPARgamma and p21WAF1/CIP1, and downregulated the expression of cyclin D1 and COX-2. Lycopene 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 68-77 29731858-8 2018 These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression. Lycopene 139-147 peroxisome proliferator activated receptor gamma Homo sapiens 175-184 21208793-5 2011 In addition, lycopene enhanced RhoA levels in the cytosolic fraction, activating peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha expressions. Lycopene 13-21 peroxisome proliferator activated receptor gamma Homo sapiens 81-129 29220836-0 2013 Correction: Lycopene Inhibits NF-kB-Mediated IL-8 Expression and Changes Redox and PPARgamma Signalling in Cigarette Smoke-Stimulated Macrophages. Lycopene 12-20 peroxisome proliferator activated receptor gamma Homo sapiens 83-92 22137263-1 2012 In our previous study, we demonstrated that lycopene can inhibit the proliferation of androgen-dependent prostate LNCaP cancer cells through the activation of the peroxisome proliferator-activated receptor gamma (PPARgamma)-liver X receptor alpha (LXRalpha)-ATP-binding cassette transporter 1 (ABCA1) pathway. Lycopene 44-52 peroxisome proliferator activated receptor gamma Homo sapiens 213-222 22137263-4 2012 We show that lycopene significantly increased protein and mRNA expression of PPARgamma, LXRalpha and ABCA1 and cholesterol efflux (i.e., decreased cellular cholesterol and increased cholesterol in culture medium). Lycopene 13-21 peroxisome proliferator activated receptor gamma Homo sapiens 77-86 22137263-5 2012 Lycopene (10 muM) in the presence of a specific antagonist of PPARgamma (GW9662) or of LXRalpha (GGPP) restored the proliferation of DU145 cells and significantly suppressed lycopene-induced protein and mRNA expression of PPARgamma and LXRalpha and cholesterol efflux. Lycopene 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 62-71 22137263-5 2012 Lycopene (10 muM) in the presence of a specific antagonist of PPARgamma (GW9662) or of LXRalpha (GGPP) restored the proliferation of DU145 cells and significantly suppressed lycopene-induced protein and mRNA expression of PPARgamma and LXRalpha and cholesterol efflux. Lycopene 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 222-231 22137263-7 2012 Furthermore, lycopene in combination with the LXRalpha agonist T0901317 exhibited synergistic effects on cell proliferation and protein expression of PPARgamma, LXRalpha and ABCA1. Lycopene 13-21 peroxisome proliferator activated receptor gamma Homo sapiens 150-159 22137263-8 2012 These results demonstrate that lycopene can inhibit DU145 cell proliferation via PPARgamma-LXRalpha-ABCA1 pathway and that lycopene and T0901317 exhibit synergistic effects. Lycopene 31-39 peroxisome proliferator activated receptor gamma Homo sapiens 81-90 21208793-7 2011 These results imply a potential role of lycopene in attenuating foam cell formation and, therefore, in preventing atherosclerosis by a cascade mechanism involving inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, RhoA inactivation and subsequent increase in PPARgamma and liver X receptor alpha activities and enhancement of ABCA1 and cav-1 expressions. Lycopene 40-48 peroxisome proliferator activated receptor gamma Homo sapiens 271-280 23746934-6 2013 Lycopene also augmented the anti-proliferative effect of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, but not Doxorubicin or Taxol, in prostate cancer. Lycopene 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 57-105 23746934-6 2013 Lycopene also augmented the anti-proliferative effect of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, but not Doxorubicin or Taxol, in prostate cancer. Lycopene 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 107-116 23746934-7 2013 Flow cytometry analyses showed that lycopene, in combination with chemotherapeutic agents and PPARgamma agonists, induced modest cell cycle arrest with significant increase in cell death by apoptosis and necrosis on prostate cancer. Lycopene 36-44 peroxisome proliferator activated receptor gamma Homo sapiens 94-103 22137263-0 2012 Lycopene and the LXRalpha agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARgamma-LXRalpha-ABCA1 pathway. Lycopene 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 139-148 21334870-0 2012 Lycopene inhibits the proliferation of androgen-dependent human prostate tumor cells through activation of PPARgamma-LXRalpha-ABCA1 pathway. Lycopene 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 107-116 21334870-2 2012 This study examined whether the anti-proliferative effect of lycopene on androgen-dependent human prostate cancer (LNCaP) cells involves the up-regulation of the expression of PPARgamma and LXRalpha. Lycopene 61-69 peroxisome proliferator activated receptor gamma Homo sapiens 176-185 21334870-5 2012 The present study is the first to demonstrate that the anti-proliferative effect of lycopene on LNCaP cells involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, leading to reduced cellular total cholesterol levels. Lycopene 84-92 peroxisome proliferator activated receptor gamma Homo sapiens 139-148 21208793-5 2011 In addition, lycopene enhanced RhoA levels in the cytosolic fraction, activating peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha expressions. Lycopene 13-21 peroxisome proliferator activated receptor gamma Homo sapiens 131-140 20573495-0 2011 Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-kappaB nuclear binding and increase in PPARgamma expression. Lycopene 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 152-161 21625550-0 2011 Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages. Lycopene 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 71-80